Specifications
- Purity
- ≥95% (HPLC)
- Appearance
- Pale yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in DMSO.
- Melting Point
- 125 °C
Category: Phytochemicals
A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens. Rutin ameliorates obesity through brown fat activation.
Synonyms | Rutoside, Phytomelin, Sophorin, Birutan, Eldrin, Birutan Forte, Rutin trihydrate, Globularicitrin, Violaquercitrin, Quercetin rutinoside |
---|---|
Purity | ≥95% (HPLC) |
Appearance | Pale yellow powder |
CAS-Number | 153-18-4 |
Molecular Formula | C27H30O16 |
Molecular Weight | 610.52 |
Identity | 1H-NMR |
Solvents | Soluble in DMSO. |
Melting Point | 125 °C |
Smiles | O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4 |
InChi Key | IKGXIBQEEMLURG-NVPNHPEKSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | RT |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
Hazard statements | H302 |
Precautionary statements | P264, P270, P301, P312, P330, P501 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) I.B. Afanas'ev, et al.; Biochem. Pharmacol. 38, 1763 (1989), (2) R.P. Webster, et al.; Cancer Lett. 109, 185 (1996), (3) E.A. Ostrakhovitch & I.B. Afanas'ev; Biochem. Pharmacol. 62, 743 (2001), (4) N. Kamalakkannan & P.S. Prince; Basic Clin. Pharmacol. Toxicol. 98, 97 (2006), (5) J.P. Lin, et al.; Leuk. Res. 33, 823 (2009), (6) R. Lapa Fda, et al.; J. Pharm. Pharmacol. 63, 875 (2011), (7) S.W. Wang, et al.; Neurotoxicology 33, 482 (2012), (8) X. Yuan, et al.; FASEB J. 31, 333 (2016) |
InChi | (1) S. Brandes, et al.: Chemistry 12, 6039 (2006), (2) R. Gahlaut, et al.: Spectr. Acta Part A: Mol. Biomol. Spectr. 109, 164 (2013), (3) F. Dogan, et al.: J. Poly,. Res. 22, 104 (2015) |
Quantity | 50 mg, Bulk |