Available from stock

Rutin

SKU: R0400

Category: Phytochemicals

Synonyms: Rutoside, Phytomelin, Sophorin, Birutan, Eldrin, Birutan Forte, Rutin trihydrate, Globularicitrin, Violaquercitrin, Quercetin rutinoside; 153-18-4
CAS-Number: C₂₇H₃₀O₁₆
Molecular Formula: 610.52
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (HPLC)
Appearance: Pale yellow powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DMSO.
Melting Point: 125 °C

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Hazard statements: H302
Precautionary statements: P264, P270, P301, P312, P330, P501
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens. Rutin ameliorates obesity through brown fat activation.
Smiles: O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4
InChi Key: IKGXIBQEEMLURG-NVPNHPEKSA-N
References: (1) I.B. Afanas'ev, et al.; Biochem. Pharmacol. 38, 1763 (1989) , (2) R.P. Webster, et al.; Cancer Lett. 109, 185 (1996) , (3) E.A. Ostrakhovitch & I.B. Afanas'ev; Biochem. Pharmacol. 62, 743 (2001) , (4) N. Kamalakkannan & P.S. Prince; Basic Clin. Pharmacol. Toxicol. 98, 97 (2006) , (5) J.P. Lin, et al.; Leuk. Res. 33, 823 (2009) , (6) R. Lapa Fda, et al.; J. Pharm. Pharmacol. 63, 875 (2011) , (7) S.W. Wang, et al.; Neurotoxicology 33, 482 (2012) , (8) X. Yuan, et al.; FASEB J. 31, 333 (2016)
InChi: (1) S. Brandes, et al.: Chemistry 12, 6039 (2006) , (2) R. Gahlaut, et al.: Spectr. Acta Part A: Mol. Biomol. Spectr. 109, 164 (2013) , (3) F. Dogan, et al.: J. Poly,. Res. 22, 104 (2015)

A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens. Rutin ameliorates obesity through brown fat activation.

SKU: R0400 Category: Phytochemicals

Additional information

Additional information

Synonyms	Rutoside, Phytomelin, Sophorin, Birutan, Eldrin, Birutan Forte, Rutin trihydrate, Globularicitrin, Violaquercitrin, Quercetin rutinoside
Purity	≥95% (HPLC)
Appearance	Pale yellow powder
CAS-Number	153-18-4
Molecular Formula	C27H30O16
Molecular Weight	610.52
Identity	1H-NMR
Solvents	Soluble in DMSO.
Melting Point	125 °C
Smiles	O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4
InChi Key	IKGXIBQEEMLURG-NVPNHPEKSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Hazard statements	H302
Precautionary statements	P264, P270, P301, P312, P330, P501
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) I.B. Afanas'ev, et al.; Biochem. Pharmacol. 38, 1763 (1989), (2) R.P. Webster, et al.; Cancer Lett. 109, 185 (1996), (3) E.A. Ostrakhovitch & I.B. Afanas'ev; Biochem. Pharmacol. 62, 743 (2001), (4) N. Kamalakkannan & P.S. Prince; Basic Clin. Pharmacol. Toxicol. 98, 97 (2006), (5) J.P. Lin, et al.; Leuk. Res. 33, 823 (2009), (6) R. Lapa Fda, et al.; J. Pharm. Pharmacol. 63, 875 (2011), (7) S.W. Wang, et al.; Neurotoxicology 33, 482 (2012), (8) X. Yuan, et al.; FASEB J. 31, 333 (2016)
InChi	(1) S. Brandes, et al.: Chemistry 12, 6039 (2006), (2) R. Gahlaut, et al.: Spectr. Acta Part A: Mol. Biomol. Spectr. 109, 164 (2013), (3) F. Dogan, et al.: J. Poly,. Res. 22, 104 (2015)
Quantity	50 mg, Bulk