Specifications
- Purity
- ≥98% (NMR)
- Appearance
- White powder
- Identity
- 1H-NMR
Properties
- Solvents
- chloroform
Available from stock
(S)-5-Chloronaproxen
- SKU
- N0271
Category: API's & Intermediates
- Synonyms
- Naproxen Impurity B, (&alpha,S)-5-Chloro-6-methoxy-&alpha,-methyl-2-naphthaleneacetic acid, (2S)-2-(5-Chloro-6-methoxy-2-naphthyl)propionic acid
- 89617-86-7
- CAS-Number
- C14H13ClO3
- Molecular Formula
- 264.70
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H302 - H315 - H319 - H335 - H361fd - H411
- Precautionary statements
- P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
- GHS Symbol
- GHS07+GHS08+GHS09
- Signal word
- Warning
- RIDADR
- UN3077
- Transportation
- Packing Group III
- Description
- (S)-5-Chloronaproxen (Naproxen Impurity B) is a chlorinated metabolite (most probably through reaction with water) from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a secondary analytical reference standard or as an organic building block and intermediate for synthesis, especially targeted chlorination.
- Smiles
- O=C(O)C(C1=CC=C2C(Cl)=C(OC)C=CC2=C1)C
- InChi Key
- RVVAYDHIVLCPBC-QMMMGPOBSA-N
- References
- (1) E.M. Santangelo, et al., Eur. J. Org. Chem. 2008, 5915 (2008) , (2) K. Solakyildirim, et al., Magn. Reson. Chem. 52, 310 (2014)
- InChi
- InChI=1S/C14H13ClO3/c1-8(14(16)17)9-3-5-11-10(7-9)4-6-12(18-2)13(11)15/h3-8H,1-2H3,(H,16,17)/t8-/m0/s1
(S)-5-Chloronaproxen (Naproxen Impurity B) is a chlorinated metabolite (most probably through reaction with water) from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a secondary analytical reference standard or as an organic building block and intermediate for synthesis, especially targeted chlorination.
Additional information
| Synonyms | Naproxen Impurity B, (&alpha,S)-5-Chloro-6-methoxy-&alpha,-methyl-2-naphthaleneacetic acid, (2S)-2-(5-Chloro-6-methoxy-2-naphthyl)propionic acid |
|---|---|
| Purity | ≥98% (NMR) |
| Appearance | White powder |
| CAS-Number | 89617-86-7 |
| Molecular Formula | C14H13ClO3 |
| Molecular Weight | 264.70 |
| Identity | 1H-NMR |
| Solvents | chloroform |
| Smiles | O=C(O)C(C1=CC=C2C(Cl)=C(OC)C=CC2=C1)C |
| InChi Key | RVVAYDHIVLCPBC-QMMMGPOBSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H302 – H315 – H319 – H335 – H361fd – H411 |
| Precautionary statements | P202 – P273 – P301 + P312 – P302 + P352 – P305 + P351 + P338 – P308 + P313 |
| GHS Symbol | GHS07+GHS08+GHS09 |
| Signal word | Warning |
| RIDADR | UN3077 |
| Transportation | Packing Group III |
| References | (1) E.M. Santangelo, et al., Eur. J. Org. Chem. 2008, 5915 (2008), (2) K. Solakyildirim, et al., Magn. Reson. Chem. 52, 310 (2014) |
| InChi | InChI=1S/C14H13ClO3/c1-8(14(16)17)9-3-5-11-10(7-9)4-6-12(18-2)13(11)15/h3-8H,1-2H3,(H,16,17)/t8-/m0/s1 |
| Quantity | 100 mg, 250 mg, Bulk |
