Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- White to off-white solid
- Identity
- 1H-NMR
Properties
- Solvents
- chloroform
Documentation
- Safety Data Sheet (SDS)
- CDX D0390 MSDS.pdf
Available from stock
(S)-O-Desmethylnaproxen
- SKU
- D0390
Category: API's & Intermediates
- Synonyms
- (S)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid , (S)-6-O-Desmethylnaproxen
- 52079-10-4
- CAS-Number
- C13H12O3
- Molecular Formula
- 216.2
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H302-H317-H400
- Precautionary statements
- P273-P280
- GHS Symbol
- GHS07+GHS09
- Signal word
- Warning
- RIDADR
- UN3077 9
- Transportation
- Excepted Quantities
- Description
- Major naproxen demethylation metabolite. Naproxen demethylation is mediated primarily by CYP2C9. Can be used for assaying naproxen metabolites.
- Smiles
- C[C@H](C(O)=O)C1=CC2=CC=C(O)C=C2C=C1
- InChi Key
- XWJUDDGELKXYNO-QMMMGPOBSA-N
- References
- (1) C.H. Kiang, et al.: Drug Metab. Dispos. 17, 43 (1989) , (2) A. Rettie, et al.: Chem. Res. Toxicol. 5, 54 (1992) , (3) T.B. Vree, et al.: Br. J. Clin. Pharmacol. 35, 467 (1993) , (4) T.B. Vree, et al.: Biopharm. Drug Dispos. 14, 491 (1993) , (5) P. Bonnabry, et al.: Eur. J. Clin. Pharmacol. 49, 305 (1996) , (6) J.O. Miners, et al.: Biochem. Pharmacol. 51, 1003 (1996) , (7) T.S. Tracy, et al.: Eur. J. Clin. Pharmacol. 52, 293 (1997) , (8) S. Rao, et al.: J. Med. Chem. 43, 2789 (2000) , (9) L. Wei, et al.: Mol. Pharmacol. 72, 1280 (2007) , (10) K.C. Duggan, et al.: J. Biol. Chem. 285, 34950 (2010)
- InChi
- InChI=1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1
Major naproxen demethylation metabolite. Naproxen demethylation is mediated primarily by CYP2C9. Can be used for assaying naproxen metabolites.
Additional information
| Synonyms | (S)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid, (S)-6-O-Desmethylnaproxen |
|---|---|
| Purity | ≥97% (HPLC) |
| Appearance | White to off-white solid |
| CAS-Number | 52079-10-4 |
| Molecular Formula | C13H12O3 |
| Molecular Weight | 216.2 |
| Identity | 1H-NMR |
| Solvents | chloroform |
| Smiles | C[C@H](C(O)=O)C1=CC2=CC=C(O)C=C2C=C1 |
| InChi Key | XWJUDDGELKXYNO-QMMMGPOBSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H302-H317-H400 |
| Precautionary statements | P273-P280 |
| GHS Symbol | GHS07+GHS09 |
| Signal word | Warning |
| RIDADR | UN3077 9 |
| Transportation | Excepted Quantities |
| References | (1) C.H. Kiang, et al.: Drug Metab. Dispos. 17, 43 (1989), (2) A. Rettie, et al.: Chem. Res. Toxicol. 5, 54 (1992), (3) T.B. Vree, et al.: Br. J. Clin. Pharmacol. 35, 467 (1993), (4) T.B. Vree, et al.: Biopharm. Drug Dispos. 14, 491 (1993), (5) P. Bonnabry, et al.: Eur. J. Clin. Pharmacol. 49, 305 (1996), (6) J.O. Miners, et al.: Biochem. Pharmacol. 51, 1003 (1996), (7) T.S. Tracy, et al.: Eur. J. Clin. Pharmacol. 52, 293 (1997), (8) S. Rao, et al.: J. Med. Chem. 43, 2789 (2000), (9) L. Wei, et al.: Mol. Pharmacol. 72, 1280 (2007), (10) K.C. Duggan, et al.: J. Biol. Chem. 285, 34950 (2010) |
| InChi | InChI=1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1 |
| Quantity | 10 mg, 50 mg, Bulk |
