Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Yellow to green powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO.
Category: API's & Intermediates
Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.
Synonyms | 6-Demethyl-6-deoxytetracycline, Bonomycin, Norcycline, GS 2147 |
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Purity | ≥98% (HPLC) |
Appearance | Yellow to green powder |
CAS-Number | 808-26-4 |
Molecular Formula | C21H22N2O7 |
Molecular Weight | 414.4 |
Identity | 1H-NMR |
Solvents | DMSO. |
Smiles | OC1=C2C(C[C@]3([H])C(C2=O)=C(O)[C@@]4(O)[C@@]([C@H](N(C)C)C(O)=C(C(N)=O)C4=O)([H])C3)=CC=C1 |
InChi Key | XDVCLKFLRAWGIT-ADOAZJKMSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H302, H362 |
Precautionary statements | P201, P260, P263, P264, P270, P330, P301+P310, P308+P313, P501 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) J.R.D. McCormick, et al., JACS 82, 3381 (1960), (2) R.T. Testa, et al., Antimicrob. Agents Chemother. 37, 2270 (1993), (3) H.M. Wexler, et al., Antimicrob. Agents Chemother. 38, 2513 (1994) |
InChi | InChI=1S/C21H22N2O7/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29/h3-5,9-10,15,24,26-27,30H,6-7H2,1-2H3,(H2,22,29)/t9-,10-,15-,21-/m0/s1 |
Quantity | 250 mg, 1 g, Bulk |