Available from stock

Sodium glycochenodeoxycholate

SKU: G0033

Category: Steroids

Synonyms: 3α,7α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide sodium salt , Glycochenodeoxycholic acid sodium salt , N-(3α,7α-Dihydroxy-24-oxocholan-24-yl)glycine sodium salt; 16564-43-5
CAS-Number: C₂₆H₄₂NNaO₅
Molecular Formula: 471.61
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: water (50 mg/ml), DMSO (slightly), ethanol, methanol (10mg/ml)

Documentation

Safety Data Sheet (SDS): CDX G0033 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Glycochenodeoxycholic acid (GCDCA) is a bile salt formed in the liver that acts as a biosurfactant to solubilize lipids for absorption and is itself absorbed. GCDCA functions as a choleretic, increasing the volume of bile secreted from the liver, and a cholagogue, promoting the discharge of bile from the digestive system. GCDCA has been used to demonstrate a role for bile acids in promoting colorectal carcinogenesis and to inhibit calcium hydroxyapatite precipitation to study the pathogenesis of black pigment gallstones. This product has also been shown to induce apoptosis in isolated hepatocytes via modulation of PKC activity. This compound is used as an anionic detergent to solubilize lipids and as a chiral reagent.
Smiles: [H][C@]1([C@@H](CCC(NCC(O[Na])=O)=O)C)CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Key: AAYACJGHNRIFCT-YRJJIGPTSA-M
References: (1) S. Barnes, et al. , J. Lipid Res. 20, 952 (1979) , (2) S.M. Qiu, et al. , J. Clin. Invest. 88, 1265 (1991) , (3) B. Gonzalez, et al. , Mol. Cell. Biochem. 207, 19 (2000) , (4) M. Iwata, et al. , Hepatol. Res. 25, 329 (2003) , (5) S. Ishizuka, et al. , Biomed. Res. 33, 159 (2012)

Glycochenodeoxycholic acid (GCDCA) is a bile salt formed in the liver that acts as a biosurfactant to solubilize lipids for absorption and is itself absorbed. GCDCA functions as a choleretic, increasing the volume of bile secreted from the liver, and a cholagogue, promoting the discharge of bile from the digestive system. GCDCA has been used to demonstrate a role for bile acids in promoting colorectal carcinogenesis and to inhibit calcium hydroxyapatite precipitation to study the pathogenesis of black pigment gallstones. This product has also been shown to induce apoptosis in isolated hepatocytes via modulation of PKC activity. This compound is used as an anionic detergent to solubilize lipids and as a chiral reagent.

SKU: G0033 Category: Steroids

Additional information

Additional information

Synonyms	3α,7α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide sodium salt, Glycochenodeoxycholic acid sodium salt, N-(3α,7α-Dihydroxy-24-oxocholan-24-yl)glycine sodium salt
Purity	≥97% (HPLC)
Appearance	White to off-white powder
CAS-Number	16564-43-5
Molecular Formula	C26H42NNaO5
Molecular Weight	471.61
Identity	1H-NMR
Solvents	water (50 mg/ml), DMSO (slightly), ethanol, methanol (10mg/ml)
Smiles	[H][C@]1([C@@H](CCC(NCC(O[Na])=O)=O)C)CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Key	AAYACJGHNRIFCT-YRJJIGPTSA-M
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) S. Barnes, et al., J. Lipid Res. 20, 952 (1979), (2) S.M. Qiu, et al., J. Clin. Invest. 88, 1265 (1991), (3) B. Gonzalez, et al., Mol. Cell. Biochem. 207, 19 (2000), (4) M. Iwata, et al., Hepatol. Res. 25, 329 (2003), (5) S. Ishizuka, et al., Biomed. Res. 33, 159 (2012)
Quantity	500 mg, 1 g, Bulk