Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- methanol, DMSO, water (slightly)
- Melting Point
- >130 °C
Available from stock
Sulfamethoxazole hydroxylamine
- SKU
- S0056
Category: API's & Intermediates
- Synonyms
- Sulfamethoxazole N4-hydroxylamine , SMX-HA , SMX-NHOH , NSC 665547 , 4-(Hydroxyamino)-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
- 114438-33-4
- CAS-Number
- C10H11N3O4S
- Molecular Formula
- 269.28
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Very hygroscopic. Store under inert gas.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H315-H317-H319-H335
- Precautionary statements
- P261-P280-P305 + P351 + P338
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Metabolite of sulfamethoxazole, a sulfonamide bacteriostatic antibiotic. Has been shown to be an important component in sulfonamide hypersensitivity reactions and has been implicated in sulfonamide-mediated immunomodulatory effects. Shown to induce lymphocyte toxicity and suppression of proliferation. Compound can be used as analytical reference material.
- Smiles
- ONC1=CC=C(S(=O)(NC2=NOC(C)=C2)=O)C=C1
- InChi Key
- MJAMPGKHIZXVFJ-UHFFFAOYSA-N
- References
- (1) J.S. Leeder, et al.: Biochem. Pharmacol. 41, 575 (1991) , (2) A.E. Cribb & S.P. Spielberg , Clin. Pharmacol. Ther. 51, 522 (1992) , (3) M.J. Rieder, et al.: Int. J. Immunopharmacol. 14, 1175 (1992) , (4) D.A. Hess, et al.: J. Pharmacol. Exp. Ther. 281, 540 (1997) , (5) D.A. Hess, et al.: FASEB J. 13, 1688 (1999) , (6) D.A. Hess, et al.: FASEB J. 15, 1855 (2001)
- InChi
- InChI=1S/C10H11N3O4S/c1-7-6-10(12-17-7)13-18(15,16)9-4-2-8(11-14)3-5-9/h2-6,11,14H,1H3,(H,12,13)
Metabolite of sulfamethoxazole, a sulfonamide bacteriostatic antibiotic. Has been shown to be an important component in sulfonamide hypersensitivity reactions and has been implicated in sulfonamide-mediated immunomodulatory effects. Shown to induce lymphocyte toxicity and suppression of proliferation. Compound can be used as analytical reference material.
Additional information
| Synonyms | Sulfamethoxazole N4-hydroxylamine, SMX-HA, SMX-NHOH, NSC 665547, 4-(Hydroxyamino)-N-(5-methyl-3-isoxazolyl)benzenesulfonamide |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | Off-white powder |
| CAS-Number | 114438-33-4 |
| Molecular Formula | C10H11N3O4S |
| Molecular Weight | 269.28 |
| Identity | 1H-NMR |
| Solvents | methanol, DMSO, water (slightly) |
| Melting Point | >130 °C |
| Smiles | ONC1=CC=C(S(=O)(NC2=NOC(C)=C2)=O)C=C1 |
| InChi Key | MJAMPGKHIZXVFJ-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Very hygroscopic. Store under inert gas. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H315-H317-H319-H335 |
| Precautionary statements | P261-P280-P305 + P351 + P338 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) J.S. Leeder, et al.: Biochem. Pharmacol. 41, 575 (1991), (2) A.E. Cribb & S.P. Spielberg, Clin. Pharmacol. Ther. 51, 522 (1992), (3) M.J. Rieder, et al.: Int. J. Immunopharmacol. 14, 1175 (1992), (4) D.A. Hess, et al.: J. Pharmacol. Exp. Ther. 281, 540 (1997), (5) D.A. Hess, et al.: FASEB J. 13, 1688 (1999), (6) D.A. Hess, et al.: FASEB J. 15, 1855 (2001) |
| InChi | InChI=1S/C10H11N3O4S/c1-7-6-10(12-17-7)13-18(15,16)9-4-2-8(11-14)3-5-9/h2-6,11,14H,1H3,(H,12,13) |
| Quantity | 10 mg, 25 mg, Bulk |
