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    Tamoxifen citrate salt

    Available from stock

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      Tamoxifen citrate salt

      SKU
      T0201

      Category: Antibiotics

      Synonyms
      (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene
      54965-24-1
      CAS-Number
      C26H29NO · C6H8O7
      Molecular Formula
      563.64
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (Titration)
      Identity
      1H-NMR
      Appearance
      White powder

      Properties

      Melting Point
      approx. 142° C
      Solvents
      methanol

      Downloads

      Safety Data Sheet
      CDX T0201 MSDS.pdf
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Long Term Storage
      +4°C
      Short Term Storage
      RT
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Signal word
      Danger
      GHS Symbol
      GHS07+GHS08
      Precautionary statements
      P201-P308 + P313
      Hazard statements
      H302-H350-H360
      Description
      Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature system. This prodrug is metabolized by cytochrome P450 (CYP450) enzymes to the active metabolites N-desmethyl-TMX, 4-hydroxy-N-desmethyl-TMX (endoxifen) and 4-hydroxy-TMX (afimoxifene). N,N-Didesmethyl-4-hydroxytamoxifen (norendoxifen), another active metabolite has been found to act as a potent competitive aromatase inhibitor and may also be involved in its antiestrogenic activity. Binds microsomal antiestrogen binding sites, altering cholesterol esterification at therapeutic doses and impacting breast cancer cell differentiation, apoptosis, and autophagy. Protein kinase C (PKC) inhibitor and anti-angiogenetic factor.
      InChi
      InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3,7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3,13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-,
      References
      K. B. Horwitz & W. L. McGuire, J. Biol. Chem. 253, 8185 (1978) , V.C. Jordan, et al., Cancer Treat. Rep. 64, 745 (1980) , C.A. O'Brian, et al., Cancer Res. 45, 2462 (1985) , K.J. Edwards, et al., J. Med. Chem. 35, 2753 (1992) , M. Clarke, et al., Lancet 351, 1451 (1998) , D.A. Tonetti & V.C. Jordan, Mol. Med. Today 2, 218 (1996) , J.M. Hall, et al., J. Biol. Chem. 276, 36869 (2001) , P. Thomas, et al., Endocrinol. 146, 624 (2005) , M.S. Singh, et al., Breast 20, 111 (2011) , P. de Medina, et al., Chem. Phys. Lip. 164, 432 (2011) , V.K. Todorova, et al., Cancer Chemother. Pharmacol. 67, 285 (2011)
      InChi Key
      FQZYTYWMLGAPFJ-OQKDUQJOSA-N
      Smiles
      CN(CCOC1=CC=C(/C(C2=CC=CC=C2)=C(C3=CC=CC=C3)/CC)C=C1)C.OC(CC(O)(C(O)=O)CC(O)=O)=O

      Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature system. This prodrug is metabolized by cytochrome P450 (CYP450) enzymes to the active metabolites N-desmethyl-TMX, 4-hydroxy-N-desmethyl-TMX (endoxifen) and 4-hydroxy-TMX (afimoxifene). N,N-Didesmethyl-4-hydroxytamoxifen (norendoxifen), another active metabolite has been found to act as a potent competitive aromatase inhibitor and may also be involved in its antiestrogenic activity. Binds microsomal antiestrogen binding sites, altering cholesterol esterification at therapeutic doses and impacting breast cancer cell differentiation, apoptosis, and autophagy. Protein kinase C (PKC) inhibitor and anti-angiogenetic factor.

      SKU: T0201 Category: Antibiotics
      • Additional information

      Additional information

      Synonyms

      (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene

      Purity

      ≥98% (Titration)

      Appearance

      White powder

      CAS-Number

      54965-24-1

      Molecular Formula

      C26H29NO · C6H8O7

      Molecular Weight

      563.64

      Identity

      1H-NMR

      Solvents

      methanol

      Melting Point

      approx. 142° C

      Smiles

      CN(CCOC1=CC=C(/C(C2=CC=CC=C2)=C(C3=CC=CC=C3)/CC)C=C1)C.OC(CC(O)(C(O)=O)CC(O)=O)=O

      InChi Key

      FQZYTYWMLGAPFJ-OQKDUQJOSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H302-H350-H360

      Precautionary statements

      P201-P308 + P313

      GHS Symbol

      GHS07+GHS08

      Signal word

      Danger

      Transportation

      Not dangerous goods

      References

      K. B. Horwitz & W. L. McGuire, J. Biol. Chem. 253, 8185 (1978), V.C. Jordan, et al., Cancer Treat. Rep. 64, 745 (1980), C.A. O'Brian, et al., Cancer Res. 45, 2462 (1985), K.J. Edwards, et al., J. Med. Chem. 35, 2753 (1992), M. Clarke, et al., Lancet 351, 1451 (1998), D.A. Tonetti & V.C. Jordan, Mol. Med. Today 2, 218 (1996), J.M. Hall, et al., J. Biol. Chem. 276, 36869 (2001), P. Thomas, et al., Endocrinol. 146, 624 (2005), M.S. Singh, et al., Breast 20, 111 (2011), P. de Medina, et al., Chem. Phys. Lip. 164, 432 (2011), V.K. Todorova, et al., Cancer Chemother. Pharmacol. 67, 285 (2011)

      InChi

      InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3,7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3,13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-,

      Quantity

      1 g, 5 g, Bulk

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