Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to light pink powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (5 mg/ml), DMF (5 mg/ml)
Category: API's & Intermediates
Temozolomide is a DNA methylating agent and drug resistance-modifying agent with antitumor and antiangiogenic properties. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and interfering with DNA replication and leading to cytotoxicity in proliferating cells. It has been shown to induce autophagy in malignant glioma cells. It is effective in a variety of types of cancer, including aggressive brain cancers.
Synonyms | 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, CCRG 81045, MB 39831, Methazolastone, NSC 362856, Temodal |
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Purity | ≥98% (HPLC) |
Appearance | White to light pink powder |
CAS-Number | 85622-93-1 |
Molecular Formula | C6H6N6O2 |
Molecular Weight | 194.15 |
Identity | 1H-NMR |
Solvents | DMSO (5 mg/ml), DMF (5 mg/ml) |
Smiles | O=C1N(C)N=NC2=C(C(N)=O)N=CN21 |
InChi Key | BPEGJWRSRHCHSN-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H302-H315-H319-H335-H350-H360 |
Precautionary statements | P201-P261-P305 + P351 + P338-P308 + P313 |
GHS Symbol | GHS07+GHS08 |
Signal word | Danger |
Transportation | Not dangerous goods |
References | (1) A.S. Clark, et al., J. Med. Chem. 38, 1493 (1995), (2) E.S. Newlands, et al., Cancer Treat. Rev. 23, 35 (1997) (Review), (3) S.S. Agarwala & J.M. Kirkwood, Oncologist 5, 144 (2000) (Review), (4) S.J. Danson & M.R. Middleton, Expert Rev. Anticancer Ther. 1, 13 (2001) (Review), (5) T. Kanzawa, et al., Cell Death Differ. 11, 448 (2004), (6) F. Marchesi, et al., Pharmacol. Res. 56, 275 (2007), (7) G. Jiang, et al., Curr. Med. Chem. 19, 3886 (2012) (Review) |
InChi | InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13) |
Quantity | 250 mg, 1 g, Bulk |