Available from stock

Temozolomide

SKU: T0072

Category: API's & Intermediates

Synonyms: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide , CCRG 81045 , MB 39831 , Methazolastone , NSC 362856 , Temodal; 85622-93-1
CAS-Number: C₆H₆N₆O₂
Molecular Formula: 194.15
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to light pink powder
Identity: 1H-NMR

Properties

Solvents: DMSO (5 mg/ml), DMF (5 mg/ml)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H302-H315-H319-H335-H350-H360
Precautionary statements: P201-P261-P305 + P351 + P338-P308 + P313
GHS Symbol: GHS07+GHS08
Signal word: Danger
Transportation: Not dangerous goods

Description: Temozolomide is a DNA methylating agent and drug resistance-modifying agent with antitumor and antiangiogenic properties. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and interfering with DNA replication and leading to cytotoxicity in proliferating cells. It has been shown to induce autophagy in malignant glioma cells. It is effective in a variety of types of cancer, including aggressive brain cancers.
Smiles: O=C1N(C)N=NC2=C(C(N)=O)N=CN21
InChi Key: BPEGJWRSRHCHSN-UHFFFAOYSA-N
References: (1) A.S. Clark, et al., J. Med. Chem. 38, 1493 (1995) , (2) E.S. Newlands, et al., Cancer Treat. Rev. 23, 35 (1997) (Review) , (3) S.S. Agarwala & J.M. Kirkwood, Oncologist 5, 144 (2000) (Review) , (4) S.J. Danson & M.R. Middleton, Expert Rev. Anticancer Ther. 1, 13 (2001) (Review) , (5) T. Kanzawa, et al., Cell Death Differ. 11, 448 (2004) , (6) F. Marchesi, et al., Pharmacol. Res. 56, 275 (2007) , (7) G. Jiang, et al., Curr. Med. Chem. 19, 3886 (2012) (Review)
InChi: InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

Temozolomide is a DNA methylating agent and drug resistance-modifying agent with antitumor and antiangiogenic properties. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and interfering with DNA replication and leading to cytotoxicity in proliferating cells. It has been shown to induce autophagy in malignant glioma cells. It is effective in a variety of types of cancer, including aggressive brain cancers.

SKU: T0072 Category: API's & Intermediates

Additional information

Additional information

Synonyms	3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, CCRG 81045, MB 39831, Methazolastone, NSC 362856, Temodal
Purity	≥98% (HPLC)
Appearance	White to light pink powder
CAS-Number	85622-93-1
Molecular Formula	C6H6N6O2
Molecular Weight	194.15
Identity	1H-NMR
Solvents	DMSO (5 mg/ml), DMF (5 mg/ml)
Smiles	O=C1N(C)N=NC2=C(C(N)=O)N=CN21
InChi Key	BPEGJWRSRHCHSN-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H302-H315-H319-H335-H350-H360
Precautionary statements	P201-P261-P305 + P351 + P338-P308 + P313
GHS Symbol	GHS07+GHS08
Signal word	Danger
Transportation	Not dangerous goods
References	(1) A.S. Clark, et al., J. Med. Chem. 38, 1493 (1995), (2) E.S. Newlands, et al., Cancer Treat. Rev. 23, 35 (1997) (Review), (3) S.S. Agarwala & J.M. Kirkwood, Oncologist 5, 144 (2000) (Review), (4) S.J. Danson & M.R. Middleton, Expert Rev. Anticancer Ther. 1, 13 (2001) (Review), (5) T. Kanzawa, et al., Cell Death Differ. 11, 448 (2004), (6) F. Marchesi, et al., Pharmacol. Res. 56, 275 (2007), (7) G. Jiang, et al., Curr. Med. Chem. 19, 3886 (2012) (Review)
InChi	InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
Quantity	250 mg, 1 g, Bulk