Specifications
- Purity
- ≥98% (TLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, methanol
- Boiling Point
- 389.4±27.0 °C at 760 mmHg
- Refractive Index
- 1.538
Category: API's & Intermediates
Tetracaine is a potent local anaesthetic and a channel function allosteric inhibitor that blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8. Shown also to reversibly block nicotinic acetylcholine (ACh) receptors (nAChRs).
Synonyms | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
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Purity | ≥98% (TLC) |
Appearance | White to off-white powder |
CAS-Number | 94-24-6 |
Molecular Formula | C15H24N2O |
Molecular Weight | 264.36 |
Identity | 1H-NMR |
Solvents | DMSO, methanol |
Boiling Point | 389.4±27.0 °C at 760 mmHg |
Refractive Index | 1.538 |
Smiles | CCCCNC1=CC=C(C(OCCN(C)C)=O)C=C1 |
InChi Key | GKCBAIGFKIBETG-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H301-H317-H351 |
Precautionary statements | P280-P301 + P310 |
GHS Symbol | GHS06+GHS08 |
Signal word | Danger |
RIDADR | UN 2811 6.1 |
Transportation | Packing Group III |
References | (1) S. Hishinuma & M.K. Uchida, Br. J. Pharmacol. 103, 1393 (1991), (2) L. Desmedt, et al., J. Gen. Physiol. 101, 103 (1993), (3) E. Jaimovich & E. Rojas, Cell Calcium. 15, 356 (1994), (4) S. Gyoerke, et al., J. Physiol. 500, 297 (1997), (5) C.L. Overend, et al., J. Physiol. 502, 471 (1997), (6) D. Mears, et al., Cell Calcium 25, 59 (1999), (7) R. Cobo, et al., Front. Mol. Neurosci. 11, 193 (2018) |
Quantity | 5 g, 25 g, 50 g, Bulk |