Available from stock
Category: Antibiotics
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Tetracycline is a broad-spectrum antibiotic that prevents bacterial growth by inhibiting protein synthesis. It binds to a single site in the 30S ribosomal subunit which prevents attachment of aminoacyl tRNA to the ribosomal acceptor site. It is used in cell biology as a selective agent in cell culture systems. Tetracycline is toxic to prokaryotic and eukaryotic cells and selects for cells harboring the bacterial tetR gene, which are resistant to the antibiotic.
| Synonyms | 2-Naphthacenecarboxamide |
|---|---|
| Purity | ≥99% (HPLC) |
| Appearance | Yellow to orange powder |
| CAS-Number | 64-75-5 |
| Molecular Formula | C22H24N2O8 · HCl |
| Molecular Weight | 480.9 |
| Identity | 1H-NMR |
| Solvents | water (10 mg/ml), DMSO, methanol or 01 N HCl (10 mg/ml) |
| Melting Point | 220-223 °C (lit.) |
| Optical Activity | [α]20/D -253º, c = 0.5 in 0.1mol/L HCl |
| Smiles | OC1=C(C(C2=C(O)[C@@](C(C(C(N)=O)=C(O)[C@H]3N(C)C)=O)(O)[C@@]3([H])C[C@]2([H])[C@@]4(O)C)=O)C4=CC=C1.Cl |
| InChi Key | XMEVHPAGJVLHIG-FMZCEJRJSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305 + P351 + P338 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) J. Degenkolb, et al.: Antimicrob. Agents. Chemother. 35, 1591 (1991), (2) D.N. Wilson: Crit. Rev. Biochem. Mol. Biol. 44, 393 (2009) |
| InChi | InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28 |
| Quantity | 5 g, 25 g, Bulk |
JC-10
