Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Light yellow to dark yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (10 mg/ml)
- Melting Point
- 220 °C
Available from stock
Thiocolchicoside
- SKU
- T0175
Category: API's & Intermediates
- Synonyms
- BRN0072205 , NSC147755 , Coltramyl , 10-thio-Colchicoside , 2-Demethoxy-2-glucosidoxythiocolchicine
- 602-41-5
- CAS-Number
- C27H33NO10S
- Molecular Formula
- 563.62
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H302, H315, H319, H335
- Precautionary statements
- P261, P264, P270 - P271, P280, P301 + P312 + P330, P302 + P352, P304 + P340 + P312, P305 + P351 + P338, P332 + P313, P337 + P313, P362, P403 + P233
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Described to be a muscle relaxant. Anti-inflammatory agent with analgesic properties. Shown to be an anticancer compound through inhibition of NF-kB and NF-kB-regulated gene products. Therapeutic option for the management of bone metastatic disease.
- Smiles
- COC1=C2C(C([C@@H](NC(C)=O)CCC2=CC(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C1OC)=C4)=CC=C(SC)C4=O
- InChi Key
- LEQAKWQJCITZNK-AXHKHJLKSA-N
- References
- (1) J.M. Janbroers, Acta Ther. 13, 221 (1987) , (2) M. Carta, et al., Neuropharmacology 51, 805 (2006) , (3) S. Reuter, et al., Cancer Prev. Res. 3, 1462 (2010) , (4) O. Micheau, et al., Br. J. Pharmacol. 165, 2124 (2012)
- InChi
- InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
Potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Described to be a muscle relaxant. Anti-inflammatory agent with analgesic properties. Shown to be an anticancer compound through inhibition of NF-kB and NF-kB-regulated gene products. Therapeutic option for the management of bone metastatic disease.
Additional information
| Synonyms | BRN0072205, NSC147755, Coltramyl, 10-thio-Colchicoside, 2-Demethoxy-2-glucosidoxythiocolchicine |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | Light yellow to dark yellow powder |
| CAS-Number | 602-41-5 |
| Molecular Formula | C27H33NO10S |
| Molecular Weight | 563.62 |
| Identity | 1H-NMR |
| Solvents | water (10 mg/ml) |
| Melting Point | 220 °C |
| Smiles | COC1=C2C(C([C@@H](NC(C)=O)CCC2=CC(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C1OC)=C4)=CC=C(SC)C4=O |
| InChi Key | LEQAKWQJCITZNK-AXHKHJLKSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | P261, P264, P270 – P271, P280, P301 + P312 + P330, P302 + P352, P304 + P340 + P312, P305 + P351 + P338, P332 + P313, P337 + P313, P362, P403 + P233 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) J.M. Janbroers, Acta Ther. 13, 221 (1987), (2) M. Carta, et al., Neuropharmacology 51, 805 (2006), (3) S. Reuter, et al., Cancer Prev. Res. 3, 1462 (2010), (4) O. Micheau, et al., Br. J. Pharmacol. 165, 2124 (2012) |
| InChi | InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1 |
| Quantity | 25 mg, 100 mg, Bulk |
