Available from stock

Thiocolchicoside

SKU: T0175

Category: API's & Intermediates

Synonyms: BRN0072205 , NSC147755 , Coltramyl , 10-thio-Colchicoside , 2-Demethoxy-2-glucosidoxythiocolchicine; 602-41-5
CAS-Number: C₂₇H₃₃NO₁₀S
Molecular Formula: 563.62
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Light yellow to dark yellow powder
Identity: 1H-NMR

Properties

Solvents: water (10 mg/ml)
Melting Point: 220 °C

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H302, H315, H319, H335
Precautionary statements: P261, P264, P270 - P271, P280, P301 + P312 + P330, P302 + P352, P304 + P340 + P312, P305 + P351 + P338, P332 + P313, P337 + P313, P362, P403 + P233
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Described to be a muscle relaxant. Anti-inflammatory agent with analgesic properties. Shown to be an anticancer compound through inhibition of NF-kB and NF-kB-regulated gene products. Therapeutic option for the management of bone metastatic disease.
Smiles: COC1=C2C(C([C@@H](NC(C)=O)CCC2=CC(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C1OC)=C4)=CC=C(SC)C4=O
InChi Key: LEQAKWQJCITZNK-AXHKHJLKSA-N
References: (1) J.M. Janbroers, Acta Ther. 13, 221 (1987) , (2) M. Carta, et al., Neuropharmacology 51, 805 (2006) , (3) S. Reuter, et al., Cancer Prev. Res. 3, 1462 (2010) , (4) O. Micheau, et al., Br. J. Pharmacol. 165, 2124 (2012)
InChi: InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1

Potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Described to be a muscle relaxant. Anti-inflammatory agent with analgesic properties. Shown to be an anticancer compound through inhibition of NF-kB and NF-kB-regulated gene products. Therapeutic option for the management of bone metastatic disease.

SKU: T0175 Category: API's & Intermediates

Additional information

Additional information

Synonyms	BRN0072205, NSC147755, Coltramyl, 10-thio-Colchicoside, 2-Demethoxy-2-glucosidoxythiocolchicine
Purity	≥98% (HPLC)
Appearance	Light yellow to dark yellow powder
CAS-Number	602-41-5
Molecular Formula	C27H33NO10S
Molecular Weight	563.62
Identity	1H-NMR
Solvents	water (10 mg/ml)
Melting Point	220 °C
Smiles	COC1=C2C(C([C@@H](NC(C)=O)CCC2=CC(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C1OC)=C4)=CC=C(SC)C4=O
InChi Key	LEQAKWQJCITZNK-AXHKHJLKSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H302, H315, H319, H335
Precautionary statements	P261, P264, P270 – P271, P280, P301 + P312 + P330, P302 + P352, P304 + P340 + P312, P305 + P351 + P338, P332 + P313, P337 + P313, P362, P403 + P233
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) J.M. Janbroers, Acta Ther. 13, 221 (1987), (2) M. Carta, et al., Neuropharmacology 51, 805 (2006), (3) S. Reuter, et al., Cancer Prev. Res. 3, 1462 (2010), (4) O. Micheau, et al., Br. J. Pharmacol. 165, 2124 (2012)
InChi	InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
Quantity	25 mg, 100 mg, Bulk