- ≥95% (NMR)
- Viscous oil
- 0.94 g/ml
- DMSO, chloroform
trans-2-Decenoic acid is an unsaturated short chain fatty acid that is secreted by S. mutans. It is a novel interkingdom-signaling molecule (from a Gram-positive organism) that inhibits hyphal formation of the dimorphic fungus C. albicans by blocking the yeast-to-hyphal morphological transition. It might play a critical role in regulating the disintegration of aerobic granules. As in other parts of the body, Streptococci and Candida coexist in the mouth and compete for the same substrate. In a mixed species environment such as the oral cavity the quantitative and qualitative nature of the bacteria modulates the biofilm formation of C. albicans. trans-2-Decenoic acid is structurally similar to undecylenic acid, the active ingredient of Desenex, a widely used antifungal agent. In addition, trans-2-Decenoic acid inhibited the luciferase reporter activity and therefore the bioluminescence of the Gram-negative marine bacteria Vibrio harveyi. trans-2-Decenoic acid is found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. Demonstrates weak estrogenic activity, inhibiting binding of 17?-estradiol to estrogen receptor ?.
trans-2-Decylenic Acid, trans-2-Decylenic Acid, Streptococcus Diffusible Signal Factor, SDSF
|Short Term Storage||
|Long Term Storage||
Protect from light and moisture.
|Use / Stability||
Stable for at least 2 years after receipt when stored at -20°C.
(1) K.M. Suzuki, et al., Evid. Based Complement. Alternat. Med. 5, 295 (2008), (2) D.G. Davies & C.N.H. Marques, J. Bateriol. 191, 1393 (2009), (3) R. Vilchez, et al., ChemBioChem 11, 1552 (2010), (4) P.-J. Cai, et al., Biores. Technol. 182, 823 (2013)
100 mg, 1 g, Bulk