Specifications
- Purity
- ≥99% (TLC)
- Appearance
- White to off-white powder
- Identity
- IR
Properties
- Solvents
- water
- Melting Point
- 273 °C (dec.) (lit.)
- Optical Activity
- [α]20/D -74° to -77°, c=1 in H2O
Documentation
- Safety Data Sheet (SDS)
- CDX T0254 MSDS.pdf
Available from stock
trans-4-Hydroxy-L-proline
- SKU
- T0254
Category: Amino Acids, Peptides, Proteins
- Synonyms
- (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid , Hyp , (S)-(-)-trans-4-Hydroxyproline , 4(R)-Hydroxy-2(S)-pyrrolidinecarboxylic acid , NSC 46704 , H-Hyp-OH , L-Hydroxypyroline
- 51-35-4
- CAS-Number
- C5H9NO3
- Molecular Formula
- 131.13
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Trans-4-Hydroxy-L-proline is a non-essential amino acid and a natural constituent of animal structural proteins such as collagen and elastin. It is commonly used as a chiral building block in the organic synthesis of various compounds, such as neuroexcitatory kainoids and antifungal echinocandins. It has been found in many bacterial secondary metabolites, including echinocandins.
- Smiles
- O[C@H]1CN[C@H](C(O)=O)C1
- InChi Key
- PMMYEEVYMWASQN-SYPWQXSBSA-N
- References
- (1) P. Remuzon, et al., Tetrahedron 44, 13803 (1996) , (2) M.J. Blanco & F.J. Sardina, J. Org. Chem. 61, 4748 (1996) , (3) J.E. Baldwin, et al., Bioorg. Med. Chem. Lett. 10, 1927 (2000) , (4) J.F. Poisson, et al., J. Org. Chem. 70, 10860 (2005) , (5) G. Cremonesi, et al., J. Org. Chem. 75, 2010 (2010)
- InChi
- InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4?/m1/s1
Trans-4-Hydroxy-L-proline is a non-essential amino acid and a natural constituent of animal structural proteins such as collagen and elastin. It is commonly used as a chiral building block in the organic synthesis of various compounds, such as neuroexcitatory kainoids and antifungal echinocandins. It has been found in many bacterial secondary metabolites, including echinocandins.
Additional information
| Synonyms | (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp, (S)-(-)-trans-4-Hydroxyproline, 4(R)-Hydroxy-2(S)-pyrrolidinecarboxylic acid, NSC 46704, H-Hyp-OH, L-Hydroxypyroline |
|---|---|
| Purity | ≥99% (TLC) |
| Appearance | White to off-white powder |
| CAS-Number | 51-35-4 |
| Molecular Formula | C5H9NO3 |
| Molecular Weight | 131.13 |
| Identity | IR |
| Solvents | water |
| Melting Point | 273 °C (dec.) (lit.) |
| Optical Activity | [α]20/D -74° to -77°, c=1 in H2O |
| Smiles | O[C@H]1CN[C@H](C(O)=O)C1 |
| InChi Key | PMMYEEVYMWASQN-SYPWQXSBSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) P. Remuzon, et al., Tetrahedron 44, 13803 (1996), (2) M.J. Blanco & F.J. Sardina, J. Org. Chem. 61, 4748 (1996), (3) J.E. Baldwin, et al., Bioorg. Med. Chem. Lett. 10, 1927 (2000), (4) J.F. Poisson, et al., J. Org. Chem. 70, 10860 (2005), (5) G. Cremonesi, et al., J. Org. Chem. 75, 2010 (2010) |
| InChi | InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4?/m1/s1 |
| Quantity | 25 g, 100 g, Bulk |
