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    Triptolide

    Available from stock

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      Triptolide

      SKU
      T0237

      Category: Antibiotics

      Synonyms
      PG 490 , NSC163062 , TPL
      38748-32-2
      CAS-Number
      C20H24O6
      Molecular Formula
      360.40
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      White to off-white powder

      Properties

      Solvents
      DMSO
      Short Term Storage
      +4°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Interferes with a number of transcription factors including p53, NF-kB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity.
      InChi
      InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
      References
      (1) S.M. Kupchan, et al., JACS 94, 7194 (1972) , (2) Y. Yang, et al., Immunopharmacology 40, 139 (1998) , (3) H. Liu, et al., Acta Pharmacol. Sin. 21, 782 (2000) , (4) B.J. Chen, Leuk. Lymphoma 42, 253 (2001) (Review) , (5) S. Yang, et al., Mol. Cancer Ther. 2, 65 (2003) , (6) S.M. Johnson, et al., J. Surg. Res. 168, 197 (2011) , (7) J. Pan, Cancer Lett. 292, 149 (2010) (Review) , (8) N. Mujumdar, et al., Gastroenterol. 139, 598 (2010) , (9) D.V. Titov, et al., Nat. Chem. Biol. 7, 182 (2011) , (10) J. Zhang, et al., Arzneimittelforschung 61, 727 (2011) , (11) Y. Lu, et al., Chem. Biol. 21, 246 (2014)
      InChi Key
      DFBIRQPKNDILPW-KTGKZQHOSA-N
      Smiles
      O=C(OC1)C2=C1C(C[C@H](O3)[C@]43[C@@]56[C@@H](O6)[C@H]7[C@@](O7)(C(C)C)[C@H]4O)[C@]5(C)CC2

      Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Interferes with a number of transcription factors including p53, NF-kB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity.

      SKU: T0237 Category: Antibiotics
      • Additional information

      Additional information

      Synonyms

      PG 490, NSC163062, TPL

      Purity

      ≥98% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      38748-32-2

      Molecular Formula

      C20H24O6

      Molecular Weight

      360.40

      Identity

      1H-NMR

      Solvents

      DMSO

      Smiles

      O=C(OC1)C2=C1C(C[C@H](O3)[C@]43[C@@]56[C@@H](O6)[C@H]7[C@@](O7)(C(C)C)[C@H]4O)[C@]5(C)CC2

      InChi Key

      DFBIRQPKNDILPW-KTGKZQHOSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Transportation

      Not dangerous goods

      References

      (1) S.M. Kupchan, et al., JACS 94, 7194 (1972), (2) Y. Yang, et al., Immunopharmacology 40, 139 (1998), (3) H. Liu, et al., Acta Pharmacol. Sin. 21, 782 (2000), (4) B.J. Chen, Leuk. Lymphoma 42, 253 (2001) (Review), (5) S. Yang, et al., Mol. Cancer Ther. 2, 65 (2003), (6) S.M. Johnson, et al., J. Surg. Res. 168, 197 (2011), (7) J. Pan, Cancer Lett. 292, 149 (2010) (Review), (8) N. Mujumdar, et al., Gastroenterol. 139, 598 (2010), (9) D.V. Titov, et al., Nat. Chem. Biol. 7, 182 (2011), (10) J. Zhang, et al., Arzneimittelforschung 61, 727 (2011), (11) Y. Lu, et al., Chem. Biol. 21, 246 (2014)

      InChi

      InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

      Quantity

      1 mg, 5 mg, Bulk

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