Triptolide

SKU: T0237

Category: Antibiotics

Synonyms: PG 490 , NSC163062 , TPL; 38748-32-2
CAS-Number: C₂₀H₂₄O₆
Molecular Formula: 360.40
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Solvents: DMSO

Short Term Storage: +4°C
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: +4°C
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Interferes with a number of transcription factors including p53, NF-kB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity.
InChi: InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
References: (1) S.M. Kupchan, et al., JACS 94, 7194 (1972) , (2) Y. Yang, et al., Immunopharmacology 40, 139 (1998) , (3) H. Liu, et al., Acta Pharmacol. Sin. 21, 782 (2000) , (4) B.J. Chen, Leuk. Lymphoma 42, 253 (2001) (Review) , (5) S. Yang, et al., Mol. Cancer Ther. 2, 65 (2003) , (6) S.M. Johnson, et al., J. Surg. Res. 168, 197 (2011) , (7) J. Pan, Cancer Lett. 292, 149 (2010) (Review) , (8) N. Mujumdar, et al., Gastroenterol. 139, 598 (2010) , (9) D.V. Titov, et al., Nat. Chem. Biol. 7, 182 (2011) , (10) J. Zhang, et al., Arzneimittelforschung 61, 727 (2011) , (11) Y. Lu, et al., Chem. Biol. 21, 246 (2014)
InChi Key: DFBIRQPKNDILPW-KTGKZQHOSA-N
Smiles: O=C(OC1)C2=C1C(C[C@H](O3)[C@]43[C@@]56[C@@H](O6)[C@H]7[C@@](O7)(C(C)C)[C@H]4O)[C@]5(C)CC2

Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Interferes with a number of transcription factors including p53, NF-kB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity.

SKU: T0237 Category: Antibiotics

Additional information

Additional information

Synonyms	PG 490, NSC163062, TPL
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	38748-32-2
Molecular Formula	C20H24O6
Molecular Weight	360.40
Identity	1H-NMR
Solvents	DMSO
Smiles	O=C(OC1)C2=C1C(C[C@H](O3)[C@]43[C@@]56[C@@H](O6)[C@H]7[C@@](O7)(C(C)C)[C@H]4O)[C@]5(C)CC2
InChi Key	DFBIRQPKNDILPW-KTGKZQHOSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) S.M. Kupchan, et al., JACS 94, 7194 (1972), (2) Y. Yang, et al., Immunopharmacology 40, 139 (1998), (3) H. Liu, et al., Acta Pharmacol. Sin. 21, 782 (2000), (4) B.J. Chen, Leuk. Lymphoma 42, 253 (2001) (Review), (5) S. Yang, et al., Mol. Cancer Ther. 2, 65 (2003), (6) S.M. Johnson, et al., J. Surg. Res. 168, 197 (2011), (7) J. Pan, Cancer Lett. 292, 149 (2010) (Review), (8) N. Mujumdar, et al., Gastroenterol. 139, 598 (2010), (9) D.V. Titov, et al., Nat. Chem. Biol. 7, 182 (2011), (10) J. Zhang, et al., Arzneimittelforschung 61, 727 (2011), (11) Y. Lu, et al., Chem. Biol. 21, 246 (2014)
InChi	InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
Quantity	1 mg, 5 mg, Bulk