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    ZnAF-2F

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    ZnAF-2F

    SKU
    Z0010

    Category: Fluorescent Detection

    Synonyms
    6-{2-[Bis(2-pyridylmethyl)amino]ethylamino}-2',7'-difluorofluorescein
    443302-09-8
    CAS-Number
    C34H26F2N4O5
    Molecular Formula
    608.59
    Molecular Weight

    • Product Data
    • Handling
    • Safety Information
    • Details

    Specifications

    Purity
    ≥95% (HPCE)
    Identity
    1H-NMR
    Appearance
    light orange powder

    Properties

    Fluorescence
    λex 492 nm, λem 517 nm in PBS, Zn2+
    Solvents
    DMSO
    Short Term Storage
    +4°C
    Use / Stability
    Stable for at least 2 years after receipt when stored at -20°C.
    Handling Advice
    Protect from light and moisture.
    Long Term Storage
    -20°C
    Shipping
    AMBIENT
    Transportation
    Not dangerous goods
    Description
    ZnAF-1F and ZnAF-2F do not fluoresce in the presence of other biologically important cations such as Ca2+ and Mg2+, and are insensitive to change of pH. The complexes with Zn2+ of previously developed ZnAFs, ZnAF-1, and ZnAF-2 decrease in fluorescence intensity below pH 7.0 owing to protonation of the phenolic hydroxyl group of fluorescein, whose pKa value is 6.2. On the other hand, the Zn2+ complexes of ZnAF-1F and ZnAF-2F emit stable fluorescence around neutral and slightly acidic conditions because the pKa values are shifted to 4.9 by substitution of electron-withdrawing fluorine at the ortho position of the phenolic hydroxyl group.
    InChi
    InChI=1S/C34H26F2N4O5/c35-27-14-25-31(16-29(27)41)44-32-17-30(42)28(36)15-26(32)34(25)24-8-7-20(13-23(24)33(43)45-34)39-11-12-40(18-21-5-1-3-9-37-21)19-22-6-2-4-10-38-22/h1-10,13-17,39,41-42H,11-12,18-19H2
    References
    (1) T. Hirano et al.: J. Am. Chem. Soc. 124(23), 6555 (2002)
    InChi Key
    VRUAOMSCYBFMTB-UHFFFAOYSA-N
    Smiles
    OC1=CC2=C(C=C1F)C1(OC(=O)C3=C1C=CC(NCCN(CC1=CC=CC=N1)CC1=NC=CC=C1)=C3)C1=CC(F)=C(O)C=C1O2

    ZnAF-1F and ZnAF-2F do not fluoresce in the presence of other biologically important cations such as Ca2+ and Mg2+, and are insensitive to change of pH. The complexes with Zn2+ of previously developed ZnAFs, ZnAF-1, and ZnAF-2 decrease in fluorescence intensity below pH 7.0 owing to protonation of the phenolic hydroxyl group of fluorescein, whose pKa value is 6.2. On the other hand, the Zn2+ complexes of ZnAF-1F and ZnAF-2F emit stable fluorescence around neutral and slightly acidic conditions because the pKa values are shifted to 4.9 by substitution of electron-withdrawing fluorine at the ortho position of the phenolic hydroxyl group.

    SKU: Z0010 Category: Fluorescent Detection
    • Additional information

    Additional information

    Synonyms

    6-{2-[Bis(2-pyridylmethyl)amino]ethylamino}-2',7'-difluorofluorescein

    Purity

    ≥95% (HPCE)

    Appearance

    light orange powder

    CAS-Number

    443302-09-8

    Molecular Formula

    C34H26F2N4O5

    Molecular Weight

    608.59

    Identity

    1H-NMR

    Solvents

    DMSO

    Fluorescence

    λex 492 nm, λem 517 nm in PBS, Zn2+

    Smiles

    OC1=CC2=C(C=C1F)C1(OC(=O)C3=C1C=CC(NCCN(CC1=CC=CC=N1)CC1=NC=CC=C1)=C3)C1=CC(F)=C(O)C=C1O2

    InChi Key

    VRUAOMSCYBFMTB-UHFFFAOYSA-N

    Shipping

    AMBIENT

    Short Term Storage

    +4°C

    Long Term Storage

    -20°C

    Handling Advice

    Protect from light and moisture.

    Use / Stability

    Stable for at least 2 years after receipt when stored at -20°C.

    Transportation

    Not dangerous goods

    References

    (1) T. Hirano et al.: J. Am. Chem. Soc. 124(23), 6555 (2002)

    InChi

    InChI=1S/C34H26F2N4O5/c35-27-14-25-31(16-29(27)41)44-32-17-30(42)28(36)15-26(32)34(25)24-8-7-20(13-23(24)33(43)45-34)39-11-12-40(18-21-5-1-3-9-37-21)19-22-6-2-4-10-38-22/h1-10,13-17,39,41-42H,11-12,18-19H2

    Quantity

    1 mg, 5 mg, 25 mg, Bulk

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