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    Biotinyl tyramide

    Available from stock

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      Biotinyl tyramide

      SKU
      B0270

      Categories: Fluorescent Detection, Fluorescent Detection

      Synonyms
      Biotin-Phenol , BP , N-(4-Hydroxyphenethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
      41994-02-9
      CAS-Number
      C18H25N3O3S
      Molecular Formula
      363.5
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥97% (HPLC)
      Appearance
      White solid
      Identity
      1H-NMR

      Properties

      Solvents
      acetonitrile, DMSO

      Documentation

      Safety Data Sheet (SDS)
      CDX B0270 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Transportation
      Not dangerous goods
      Description
      Biotin derivative. Substrate of the horseradish peroxidase enzyme and used as a reagent to amplify immunohistochemical signals. It is based on the HRP-catalyzed deposition of tyramide conjugates (such as biotinyl-tyramide) on a solid phase. Subsequent reaction with streptavidin fluorophore results in the localization of the fluorophore at the site of tyramide deposition. This fluorescence-based tyramide signal amplification (TSA) has been widely used in immunohistochemistry, immunohistochemistry, immunoelectron microscopy, fluorescent in situ hybridization (FISH) and fluorescence ELISA. The TSA method has been reported to increase the detection sensitivity up to 100-fold as compared with conventional avidin–biotinylated enzyme complex procedures. It can be used together with both chromogenic and fluorescence visualization methods. It can be added to any other standard IHC protocol and reduces the use of other reagents, improves signal to noise by reducing the titer of other reagents in the assay protocol and enables multi-target detection in both IHC and (F)ISH applications.
      Smiles
      [H][C@]12CS[C@@H](CCCCC(=O)NCCC3=CC=C(O)C=C3)[C@@]1([H])NC(=O)N2
      InChi Key
      VZWXNOBHWODXCW-ZOBUZTSGSA-N
      References
      (1) B. Hunyady, et al.: J. Histochem. Cytochem. 44, 1353 (1996) , (2) G. Mayer, et al.: J. Histochem. Cytochem. 45, 1449 (1997) , (3) J.A. McKay, et al.: Mol. Path. 50, 322 (1997) , (4) M.F. Evans, et al.: Mod. Pathol. 15, 1339 (2002) , (5) Q. Chenac, et al.: Anal. Lett. 45, 219 (2012) , (6) H. Gong, et al.: Anal. Bioch. 426, 27 (2012) , (7) E. Draberova, et al.: J. Immunol. Methods 395, 63 (2013)
      InChi
      InChI=1S/C18H25N3O3S/c22-13-7-5-12(6-8-13)9-10-19-16(23)4-2-1-3-15-17-14(11-25-15)20-18(24)21-17/h5-8,14-15,17,22H,1-4,9-11H2,(H,19,23)(H2,20,21,24)/t14-,15-,17-/m0/s1

      Biotin derivative. Substrate of the horseradish peroxidase enzyme and used as a reagent to amplify immunohistochemical signals. It is based on the HRP-catalyzed deposition of tyramide conjugates (such as biotinyl-tyramide) on a solid phase. Subsequent reaction with streptavidin fluorophore results in the localization of the fluorophore at the site of tyramide deposition. This fluorescence-based tyramide signal amplification (TSA) has been widely used in immunohistochemistry, immunohistochemistry, immunoelectron microscopy, fluorescent in situ hybridization (FISH) and fluorescence ELISA. The TSA method has been reported to increase the detection sensitivity up to 100-fold as compared with conventional avidin–biotinylated enzyme complex procedures. It can be used together with both chromogenic and fluorescence visualization methods. It can be added to any other standard IHC protocol and reduces the use of other reagents, improves signal to noise by reducing the titer of other reagents in the assay protocol and enables multi-target detection in both IHC and (F)ISH applications.

      SKU: B0270 Categories: Fluorescent Detection, Fluorescent Detection
      • Additional information

      Additional information

      Synonyms

      Biotin-Phenol, BP, N-(4-Hydroxyphenethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

      Purity

      ≥97% (HPLC)

      Appearance

      White solid

      CAS-Number

      41994-02-9

      Molecular Formula

      C18H25N3O3S

      Molecular Weight

      363.5

      Identity

      1H-NMR

      Solvents

      acetonitrile, DMSO

      Smiles

      [H][C@]12CS[C@@H](CCCCC(=O)NCCC3=CC=C(O)C=C3)[C@@]1([H])NC(=O)N2

      InChi Key

      VZWXNOBHWODXCW-ZOBUZTSGSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) B. Hunyady, et al.: J. Histochem. Cytochem. 44, 1353 (1996), (2) G. Mayer, et al.: J. Histochem. Cytochem. 45, 1449 (1997), (3) J.A. McKay, et al.: Mol. Path. 50, 322 (1997), (4) M.F. Evans, et al.: Mod. Pathol. 15, 1339 (2002), (5) Q. Chenac, et al.: Anal. Lett. 45, 219 (2012), (6) H. Gong, et al.: Anal. Bioch. 426, 27 (2012), (7) E. Draberova, et al.: J. Immunol. Methods 395, 63 (2013)

      InChi

      InChI=1S/C18H25N3O3S/c22-13-7-5-12(6-8-13)9-10-19-16(23)4-2-1-3-15-17-14(11-25-15)20-18(24)21-17/h5-8,14-15,17,22H,1-4,9-11H2,(H,19,23)(H2,20,21,24)/t14-,15-,17-/m0/s1

      Quantity

      100 mg, 500 mg, Bulk

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