Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to beige powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (10 mg/ml), ethanol (25 mg/ml), DMSO (20 mg/ml)
- Optical Activity
- [α]/D +48 to +58°, c = 1 in H2O
Available from stock
Dexmedetomidine hydrochloride
- SKU
- D0792
Categories:
- Synonyms
- Dex , Precedex , (+)-Medetomidine hydrochloride , (S)-Medetomidine hydrochloride , 4-[(S)-α,2,3-Trimethylbenzyl]imidazole monohydrochloride
- 145108-58-3
- CAS-Number
- C13H16N2 · HCl
- Molecular Formula
- 236.74
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305 + P351 + P338
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Dexmedetomidine hydrochloride is the active isomer of medetomidine and is a highly potent and selective α2-adrenergic agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively) with analgesic and sedative properties. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression. It is active in vivo, displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
- Smiles
- CC1=C(C)C([C@@H](C2=CN=C[NH2+]2)C)=CC=C1.[Cl-]
- InChi Key
- VPNGEIHDPSLNMU-MERQFXBCSA-N
- References
- (1) R. Virtanen, et al., Eur. J. Pharmacol. 150, 9 (1988) , (2) H. Scheinin, et al., Prog. Neuropsychopharm. Biol. Psychiat. 13, 635 (1989) (Review) , (3) R. Gertler, et al., Proc. (Bayl. Univ. Med. Cent.) 14, 13 (2001) , (4) S. Bajwa & A. Kulshrestha, Ann. Med. Health Sci. Res. 3, 475 (2013) , (5) Y. Cai, et al., Mol. Med. Rep. 9, 1542 (2014) (Review) , (6) M. Maze, Anesthesiology 125, 590 (2016) (Review) , (7) C. Tang & Z. Xia, J. Pain Res. 10, 1899 (2017) (Review)
- InChi
- InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13,/h4-8,11H,1-3H3,(H,14,15),1H/t11-,/m0./s1
Dexmedetomidine hydrochloride is the active isomer of medetomidine and is a highly potent and selective α2-adrenergic agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively) with analgesic and sedative properties. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression. It is active in vivo, displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
Additional information
| Synonyms | Dex, Precedex, (+)-Medetomidine hydrochloride, (S)-Medetomidine hydrochloride, 4-[(S)-α,2,3-Trimethylbenzyl]imidazole monohydrochloride |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to beige powder |
| CAS-Number | 145108-58-3 |
| Molecular Formula | C13H16N2 · HCl |
| Molecular Weight | 236.74 |
| Identity | 1H-NMR |
| Solvents | water (10 mg/ml), ethanol (25 mg/ml), DMSO (20 mg/ml) |
| Optical Activity | [α]/D +48 to +58°, c = 1 in H2O |
| Smiles | CC1=C(C)C([C@@H](C2=CN=C[NH2+]2)C)=CC=C1.[Cl-] |
| InChi Key | VPNGEIHDPSLNMU-MERQFXBCSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305 + P351 + P338 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) R. Virtanen, et al., Eur. J. Pharmacol. 150, 9 (1988), (2) H. Scheinin, et al., Prog. Neuropsychopharm. Biol. Psychiat. 13, 635 (1989) (Review), (3) R. Gertler, et al., Proc. (Bayl. Univ. Med. Cent.) 14, 13 (2001), (4) S. Bajwa & A. Kulshrestha, Ann. Med. Health Sci. Res. 3, 475 (2013), (5) Y. Cai, et al., Mol. Med. Rep. 9, 1542 (2014) (Review), (6) M. Maze, Anesthesiology 125, 590 (2016) (Review), (7) C. Tang & Z. Xia, J. Pain Res. 10, 1899 (2017) (Review) |
| InChi | InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13,/h4-8,11H,1-3H3,(H,14,15),1H/t11-,/m0./s1 |
| Quantity | 10 mg, 50 mg, Bulk |
