Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- ethanol, DMSO, DMF (30 mg/ml)
Available from stock
Dihydrocapsaicin
- SKU
- D0679
Category: Phytochemicals
- Synonyms
- 6,7-Dihydrocapsaicin , 8-Methyl-N-vanillylnonanamide , N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methylnonenamide
- 19408-84-5
- CAS-Number
- C18H29NO3
- Molecular Formula
- 307.43
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H301-H315-H319-H335
- Precautionary statements
- P261-P301 + P310-P305 + P351 + P338
- GHS Symbol
- GHS06
- Signal word
- Danger
- RIDADR
- UN 3462 6.1
- Transportation
- Packing Group II
- Description
- Dihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers (capsicum). Dihydrocapsaicin accounts for about 10% of the total capsaicinoid mixture and separation by HPLC is required in order to obtain pure dihydrocapsaicin. Dihydrocapsaicin, similar as capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. VR1 (vanilloid receptor 1) is a heat activated calcium ion channel which functions as a part of the normal nociceptive pain pathway. Shown to be analgesic against arthritis pain and inflammation and protective effects against high cholesterol levels and obesity. Induced autophagy, apoptosis in glioma cells via ROS-dependent pathways.
- Smiles
- OC1=C(OC)C=C(CNC(CCCCCCC(C)C)=O)C=C1
- InChi Key
- XJQPQKLURWNAAH-UHFFFAOYSA-N
- References
- (1) E. Leete & W.C. Louden, JACS 90, 6837 (1968) , (2) M.S. Miller, et al., Eur. J. Pharmacol. 83, 289 (1982) , (3) P.M. Gannett, et al., J. Org. Chem. 53, 1064 (1988) , (4) M.J. Caterina, et al., Nature 389, 816 (1997) , (5) J. Szocsany, Neuropeptides 38, 377 (2004) , (6) R. Kempaiah, et al., Mol. Cell. Biol. 275, 7 (2005) , (7) S.H. Oh, et al., Autophagy 4, 1009 (2008) , (8) M. Halme, et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1009-1010, 17 (2016) , (9) J.J. Zhao, et al., Arch. Biochem. Biophys. 604, 27 (2016) , (10) L. Xie, et al., Mol. Med. Rep. 14, 4198 (2016)
Dihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers (capsicum). Dihydrocapsaicin accounts for about 10% of the total capsaicinoid mixture and separation by HPLC is required in order to obtain pure dihydrocapsaicin. Dihydrocapsaicin, similar as capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. VR1 (vanilloid receptor 1) is a heat activated calcium ion channel which functions as a part of the normal nociceptive pain pathway. Shown to be analgesic against arthritis pain and inflammation and protective effects against high cholesterol levels and obesity. Induced autophagy, apoptosis in glioma cells via ROS-dependent pathways.
Additional information
| Synonyms | 6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methylnonenamide |
|---|---|
| Purity | ≥97% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 19408-84-5 |
| Molecular Formula | C18H29NO3 |
| Molecular Weight | 307.43 |
| Identity | 1H-NMR |
| Solvents | ethanol, DMSO, DMF (30 mg/ml) |
| Smiles | OC1=C(OC)C=C(CNC(CCCCCCC(C)C)=O)C=C1 |
| InChi Key | XJQPQKLURWNAAH-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H301-H315-H319-H335 |
| Precautionary statements | P261-P301 + P310-P305 + P351 + P338 |
| GHS Symbol | GHS06 |
| Signal word | Danger |
| RIDADR | UN 3462 6.1 |
| Transportation | Packing Group II |
| References | (1) E. Leete & W.C. Louden, JACS 90, 6837 (1968), (2) M.S. Miller, et al., Eur. J. Pharmacol. 83, 289 (1982), (3) P.M. Gannett, et al., J. Org. Chem. 53, 1064 (1988), (4) M.J. Caterina, et al., Nature 389, 816 (1997), (5) J. Szocsany, Neuropeptides 38, 377 (2004), (6) R. Kempaiah, et al., Mol. Cell. Biol. 275, 7 (2005), (7) S.H. Oh, et al., Autophagy 4, 1009 (2008), (8) M. Halme, et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1009-1010, 17 (2016), (9) J.J. Zhao, et al., Arch. Biochem. Biophys. 604, 27 (2016), (10) L. Xie, et al., Mol. Med. Rep. 14, 4198 (2016) |
| Quantity | 5 mg, 25 mg, Bulk |
