Available from stock

N-tert-Butyl-alpha-phenylnitrone [PBN]

SKU: B0269

Category: Building Blocks, Intermediates, Reagents

Synonyms: Phenyl N-t-butylnitrone , N-tert-Butyl-alpha-phenylnitrone , N-Benzylidene-N-(2-methyl-2-propanyl)amine oxide , (Z)-N-Benzylidene-2-methylpropan-2-amine oxide; 3376-24-7
CAS-Number: C₁₁H₁₅NO
Molecular Formula: 177.2
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (GC)
Appearance: White to off-white crystals
Identity: 1H-NMR

Properties

Solvents: DMSO

Documentation

Safety Data Sheet (SDS): CDX B0269 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Cell permeable spin trap commonly used in free radical research for both in vivo and in vitro studies. It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects. PBN has been shown to inhibit LPS-induced NF-kappaB DNA binding activity, inhibit COX-2 catalytic activity, inhibit lipid peroxidation in rat liver microsomes and prevent the induction of inducible nitric oxide synthase (iNOS). Shows anti-cancer activity in several experimental cancer models.
Smiles: CC(C)(C)[N+]([O-])=CC1=CC=CC=C1
InChi Key: IYSYLWYGCWTJSG-UHFFFAOYSA-N
References: (1) R.A. Floyd: FASEB J. 4, 2587-4597 (1990) , (2) R.F. Haseloff: FEBS Lett. 418, 73 (1997) , (3) R.A. Floyd: Adv. Pharmacol. 38, 361 (1997) , (4) T. Miyajima & Y. Kotake: Free Radic. Biol. Med. 22, 463 (1997) , (5) Y. Kotake, et al.: Biochim. Biophys. Acta 1448, 77 (1998) , (6) R.A. Floyd: Proc. Soc. Exp. Biol. Med. 222, 236 (1999) (Review) , (7) Y. Kotake: Antioxid. Redox Signal. 1, 481 (1999) (Review) , (8) E. Ho, et al.: Free Radic. Biol. Med. 28, 604 (2000) , (9) P. Kelicen, et al.: Neuroreport 13, 1057 (2002) , (10) W.N. Hassan, et al.: Free Radic. Biol. Med. 32, 551 (2002) , (11) K. Saito & H. Yoshioka: Free Radic. Res. 36, 143 (2002) , (12) R.A Floyd: Anticanc. Agents Med. Chem. 11, 373 (2011)
InChi: InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3

Cell permeable spin trap commonly used in free radical research for both in vivo and in vitro studies. It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects. PBN has been shown to inhibit LPS-induced NF-kappaB DNA binding activity, inhibit COX-2 catalytic activity, inhibit lipid peroxidation in rat liver microsomes and prevent the induction of inducible nitric oxide synthase (iNOS). Shows anti-cancer activity in several experimental cancer models.

SKU: B0269 Category: Building Blocks, Intermediates, Reagents

Additional information

Additional information

Synonyms	Phenyl N-t-butylnitrone, N-tert-Butyl-alpha-phenylnitrone, N-Benzylidene-N-(2-methyl-2-propanyl)amine oxide, (Z)-N-Benzylidene-2-methylpropan-2-amine oxide
Purity	≥98% (GC)
Appearance	White to off-white crystals
CAS-Number	3376-24-7
Molecular Formula	C11H15NO
Molecular Weight	177.2
Identity	1H-NMR
Solvents	DMSO
Smiles	CC(C)(C)[N+]([O-])=CC1=CC=CC=C1
InChi Key	IYSYLWYGCWTJSG-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) R.A. Floyd: FASEB J. 4, 2587-4597 (1990), (2) R.F. Haseloff: FEBS Lett. 418, 73 (1997), (3) R.A. Floyd: Adv. Pharmacol. 38, 361 (1997), (4) T. Miyajima & Y. Kotake: Free Radic. Biol. Med. 22, 463 (1997), (5) Y. Kotake, et al.: Biochim. Biophys. Acta 1448, 77 (1998), (6) R.A. Floyd: Proc. Soc. Exp. Biol. Med. 222, 236 (1999) (Review), (7) Y. Kotake: Antioxid. Redox Signal. 1, 481 (1999) (Review), (8) E. Ho, et al.: Free Radic. Biol. Med. 28, 604 (2000), (9) P. Kelicen, et al.: Neuroreport 13, 1057 (2002), (10) W.N. Hassan, et al.: Free Radic. Biol. Med. 32, 551 (2002), (11) K. Saito & H. Yoshioka: Free Radic. Res. 36, 143 (2002), (12) R.A Floyd: Anticanc. Agents Med. Chem. 11, 373 (2011)
InChi	InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3
Quantity	1 g, 5 g, Bulk