Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- chloroform, DMF (15 mg/ml), DMSO (2 mg/ml)
- Melting Point
- 229-232 °C (lit.)
- Optical Activity
- [α]20/D -126°, c = 1.5 in acetic acid
Category: Phytochemicals
Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological properties such as anti-inflammatory, immunosuppressive, antidiabetic, antihyperglycemic, antibacterial, antioxidant, antinoniceptive, antimalarial, anticancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus. It blocks T-cell proliferation and the proliferation of several cancer cell lines in vitro. It acts as an irreversible antagonist of NF-?B and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation.
Synonyms | Andrographis |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White to light yellow powder |
CAS-Number | 5508-58-7 |
Molecular Formula | C20H30O5 |
Molecular Weight | 350.455 |
Identity | 1H-NMR |
Solvents | chloroform, DMF (15 mg/ml), DMSO (2 mg/ml) |
Melting Point | 229-232 °C (lit.) |
Optical Activity | [α]20/D -126°, c = 1.5 in acetic acid |
Smiles | C=C1CC[C@@]([C@@](CO)(C)[C@H](O)CC2)([H])[C@]2(C)[C@@H]1C/C=C3C(OC[C@H]/3O)=O |
InChi Key | BOJKULTULYSRAS-OTESTREVSA-N |
Shipping | AMBIENT |
Short Term Storage | -20°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H315, H319, H335 |
Precautionary statements | P264, P280, P261, P362+364 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) P.K. Visen, et al., J. Ethnopharmacol. 40, 131 (1993), (2) W.F. Chiou, et al., Br. J. Pharmacol. 129, 1553 (2000), (3) B.C. Yu, et al., Planta Med. 69, 1075 (2003), (4) Y.F. Xia, et al., J. Immunol. 173, 4207 (2004), (5) J.H. Chen, et al., Biochem. Pharmacol. 67, 1337 (2004), (6) R.A. Burgos, et al., Planta Med. 71, 429 (2005), (7) M.I. Iruretagoyena, et al., J. Pharmacol. Exp. Ther. 312, 366 (2005), (8) C. Liu, et al., Genes Cancer 2, 151 (2011), (9) J.C. Lim, et al., Clin. Exp. Pharmacol. Physiol. 39, 300 (2012) (Review), (10) S.K. Mishra, et al., Front. Biosci. 7, 255 (2015) (Review), (11) V. Kishore, et al., Curr. Top. Med. Chem. 17, 845 (2017) (Review), (12) S. Gupta, et al., Arch. Virol. 162, 611 (2017) (Review), (13) W.S.D. Tan, et al., Biochem. Pharmacol. 139, 71 (2017) (Review), (14) C.H. Yang, et al., Int. J. Mol. Sci. 18, E1638 (2017) (Review), (15) M.T. Islam, Front. Pharmacol. 8, 571 (2017) (Review), (16) J. Lu, et al., Biomed. Pharmacother. 117, 109078 (2019) (Review), (17) L. Zhang, et al., Pharmacology (Epub ahead of print) (2019) (Review), (18) E. Mussard, et al., Antioxidants 8, E571 (2019) (Review) |
InChi | InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1 |
Quantity | 500 mg, Bulk |