Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- Light-Yellow Powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), DMF (10 mg/ml)
- Melting Point
- 258-259° C
Category: Phytochemicals
Genistin is a natural isoflavone glycoside isolated from legumes (e.g. soy). It is a selective inhibitor of mammalian terminal deoxyribonucleotidyl-transferase (TdT), with no measurable effect on mammalian or microbial DNA polymerases. Disrupts cell cycle and induces apoptosis in human ovarian cancer SK-OV-3 cells. Inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo. Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It also increases bone formation in collagen matrix in vivo. Could also be used as a negative control for the PTK inhibitor Genistein.
Synonyms | Genistein glycoside, NSC 5112, 4',5,7-Trihydroxyisoflavone 7-glucoside |
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Purity | ≥97% (HPLC) |
Appearance | Light-Yellow Powder |
CAS-Number | 529-59-9 |
Molecular Formula | C21H20O10 |
Molecular Weight | 432.38 |
Identity | 1H-NMR |
Solvents | DMSO (10 mg/ml), DMF (10 mg/ml) |
Melting Point | 258-259° C |
Smiles | OC[C@H]1O[C@@H](OC2=CC(OC=C(C3=CC=C(O)C=C3)C4=O)=C4C(O)=C2)[C@H](O)[C@@H](O)[C@@H]1O |
InChi Key | ZCOLJUOHXJRHDI-CMWLGVBASA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) C.D. Allred, et al., Carcinogenesis 22, 1667 (2001), (2) T. Uesugi, et al., Biol. Pharm. Bull. 24, 368 (2001), (3) Y. Uchiyama, et al., Biochim. Biophys. Acta, 1725, 298 (2005), (4) A. Russo, et al., J. Nutr. Biochem. 17, 103 (2006), (5) E.J. Choi, et al., Life Sci. 80, 1403 (2007), (6) R.W. Wong & A.B. Rabie, Front. Biosci. 2, 764 (2010) |
Quantity | 5 mg, 25 mg, Bulk |