Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White powder
Properties
- Solvents
- water (10 mg/ml) or DMSO.
Category: Carbohydrates
Rebaudioside A is a glucosylated steviol glycoside studied and used as a non-glycemic sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. Rebaudioside A is a α-glucosidase inhibitor with (IC50=35μg/ml) and can inhibit ATP-sensitive K+-channels. In vitro rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine moδ Rebaudioside A is metabolized by gut microbiota to steviol. Rebaudioside A shows antioxidant activity on reducing cellular reactive oxygen species. It is an activator of Nrf2 and is a potential candidate hepatoprotective agent.
Synonyms | Glycoside A3, Glycoside X, Stevioside A3, Reb A |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White powder |
CAS-Number | 58543-16-1 |
Molecular Formula | C44H70O23 |
Molecular Weight | 967.01 |
Solvents | water (10 mg/ml) or DMSO. |
Smiles | C=C1[C@@]2(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@H](O)[C@@H](CO)O3)C[C@]6(C1)CC[C@]7([H])[C@](C)(C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=O)CCC[C@@]7(C)[C@]6([H])CC2 |
InChi Key | HELXLJCILKEWJH-NCGAPWICSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | RT |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
Transportation | Not dangerous goods |
References | (1) R. Abudula, et al., Metab.53, 1378 (2004), (2) R. Abudula, et al., Diabetes Obes. Metab. 10, 1074 (2008), (3) D.J. Brusick, Food Chem. Toxicol. 46, S83 (2008), (4) M. Upreti, et al., Molecules 17, 4186 (2012), (5) D. Ripken, et al., J. Agric. Food Chem. 62, 8365 (2014), (6) N. van der Wielen, et al., J. Nutr. 146, 2429 (2016), (7) D.H. Shin, et al., Diabetes Metab. J. 40, 283 (2016), (8) B.R. Adari, et al., Food Chem. 200, 154 (2016), (9) Y. Wang, et al., Eur. J. Pharmacol. 822, 128 (2018) |
InChi | InChI=1S/C44H70O23/c1-17-11-43-9-5-22-41(2,7-4-8-42(22,3)40(59)66-38-33(58)30(55)26(51)20(14-47)62-38)23(43)6-10-44(17,16-43)67-39-35(65-37-32(57)29(54)25(50)19(13-46)61-37)34(27(52)21(15-48)63-39)64-36-31(56)28(53)24(49)18(12-45)60-36/h18-39,45-58H,1,4-16H2,2-3H3/t18-,19-,20-,21-,22+,23+,24-,25-,26-,27-,28+,29+,30+,31-,32-,33-,34+,35-,36+,37+,38+,39+,41-,42-,43-,44+/m1/s1 |
Quantity | 5 g, 25 g, 50 g, Bulk |