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    6-(4-Acetamido-1

    Available from stock

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      6-(4-Acetamido-1,8-naphthalamido) hexanoic acid

      SKU
      A0038

      Categories: Fluorescent Detection, Fluorescent Detection

      172227-59-7
      CAS-Number
      C20H20N2O5
      Molecular Formula
      368.38
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPCE)
      Appearance
      Solid
      Identity
      1H-NMR

      Properties

      Solvents
      water, DMSO
      Fluorescence
      λex 364 nm, λem 476 nm in 0.1 M phosphate pH 7.0

      Documentation

      Safety Data Sheet (SDS)
      CDX A0038 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Transportation
      Not dangerous goods
      Description
      The highly fluorescent label 4-acetylamino-1,8-naphthalimide-N-caproic acid has two fused benzene rings containing a closed anhydride ring and therefore is a flat and planar molecule which can easily intercalate or act as a groove binder with DNA/RNA sequences. For the study of in situ hydridization with complementary synthetic oligonucleotides (ODNs), tagging with non-radioactive labels has gained importance, not only for medical diagnostics or clinical genetics, but also detection and isolation of DNA for research purposes. The pentamethylene chain in 6 acts as a linker molecule and keeps the target at a reasonable distance to avoid direct interaction with oligonucleotides.
      Smiles
      CC(=O)NC1=CC=C2C(=O)N(CC(O)=O)C(=O)C3=C2C1=CC=C3
      InChi Key
      RCZAYEHQRFPFSH-UHFFFAOYSA-N
      References
      (1) K. Misra et al.: Radiobiol. Bio-Med. Res. 129 (2004) , (2) R.W. Odd et al.: Blackwell Scientific Publication, 317 (1992) , (3) R.J. Kaiser et al.: Nucleic Acids Research 17, 6087 (1989)
      InChi
      InChI=1S/C20H20N2O5/c1-12(23)21-16-10-9-15-18-13(16)6-5-7-14(18)19(26)22(20(15)27)11-4-2-3-8-17(24)25/h5-7,9-10H,2-4,8,11H2,1H3,(H,21,23)(H,24,25)

      The highly fluorescent label 4-acetylamino-1,8-naphthalimide-N-caproic acid has two fused benzene rings containing a closed anhydride ring and therefore is a flat and planar molecule which can easily intercalate or act as a groove binder with DNA/RNA sequences. For the study of in situ hydridization with complementary synthetic oligonucleotides (ODNs), tagging with non-radioactive labels has gained importance, not only for medical diagnostics or clinical genetics, but also detection and isolation of DNA for research purposes. The pentamethylene chain in 6 acts as a linker molecule and keeps the target at a reasonable distance to avoid direct interaction with oligonucleotides.

      SKU: A0038 Categories: Fluorescent Detection, Fluorescent Detection
      • Additional information

      Additional information

      Purity

      ≥95% (HPCE)

      Appearance

      Solid

      CAS-Number

      172227-59-7

      Molecular Formula

      C20H20N2O5

      Molecular Weight

      368.38

      Identity

      1H-NMR

      Solvents

      water, DMSO

      Fluorescence

      λex 364 nm, λem 476 nm in 0.1 M phosphate pH 7.0

      Smiles

      CC(=O)NC1=CC=C2C(=O)N(CC(O)=O)C(=O)C3=C2C1=CC=C3

      InChi Key

      RCZAYEHQRFPFSH-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) K. Misra et al.: Radiobiol. Bio-Med. Res. 129 (2004), (2) R.W. Odd et al.: Blackwell Scientific Publication, 317 (1992), (3) R.J. Kaiser et al.: Nucleic Acids Research 17, 6087 (1989)

      InChi

      InChI=1S/C20H20N2O5/c1-12(23)21-16-10-9-15-18-13(16)6-5-7-14(18)19(26)22(20(15)27)11-4-2-3-8-17(24)25/h5-7,9-10H,2-4,8,11H2,1H3,(H,21,23)(H,24,25)

      Quantity

      10 mg, 50 mg, Bulk

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