Specifications
- Purity
- ≥95% (HPCE)
- Appearance
- Solid
- Identity
- 1H-NMR
Properties
- Fluorescence
- λex 364 nm, λem 476 nm in 0.1 M phosphate pH 7.0
- Solvents
- water, DMSO
Available from stock
6-(4-Acetamido-1,8-naphthalamido) hexanoic acid
- SKU
- A0038
Category: Fluorescent Detection
- 172227-59-7
- CAS-Number
- C20H20N2O5
- Molecular Formula
- 368.38
- Molecular Weight
- Short Term Storage
- +4°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- -20°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- The highly fluorescent label 4-acetylamino-1,8-naphthalimide-N-caproic acid has two fused benzene rings containing a closed anhydride ring and therefore is a flat and planar molecule which can easily intercalate or act as a groove binder with DNA/RNA sequences. For the study of in situ hydridization with complementary synthetic oligonucleotides (ODNs), tagging with non-radioactive labels has gained importance, not only for medical diagnostics or clinical genetics, but also detection and isolation of DNA for research purposes. The pentamethylene chain in 6 acts as a linker molecule and keeps the target at a reasonable distance to avoid direct interaction with oligonucleotides.
- InChi
- InChI=1S/C20H20N2O5/c1-12(23)21-16-10-9-15-18-13(16)6-5-7-14(18)19(26)22(20(15)27)11-4-2-3-8-17(24)25/h5-7,9-10H,2-4,8,11H2,1H3,(H,21,23)(H,24,25)
- References
- (1) K. Misra et al.: Radiobiol. Bio-Med. Res. 129 (2004) , (2) R.W. Odd et al.: Blackwell Scientific Publication, 317 (1992) , (3) R.J. Kaiser et al.: Nucleic Acids Research 17, 6087 (1989)
- InChi Key
- RCZAYEHQRFPFSH-UHFFFAOYSA-N
- Smiles
- CC(=O)NC1=CC=C2C(=O)N(CC(O)=O)C(=O)C3=C2C1=CC=C3
The highly fluorescent label 4-acetylamino-1,8-naphthalimide-N-caproic acid has two fused benzene rings containing a closed anhydride ring and therefore is a flat and planar molecule which can easily intercalate or act as a groove binder with DNA/RNA sequences. For the study of in situ hydridization with complementary synthetic oligonucleotides (ODNs), tagging with non-radioactive labels has gained importance, not only for medical diagnostics or clinical genetics, but also detection and isolation of DNA for research purposes. The pentamethylene chain in 6 acts as a linker molecule and keeps the target at a reasonable distance to avoid direct interaction with oligonucleotides.
Additional information
| Purity | ≥95% (HPCE) |
|---|---|
| Appearance | Solid |
| CAS-Number | 172227-59-7 |
| Molecular Formula | C20H20N2O5 |
| Molecular Weight | 368.38 |
| Identity | 1H-NMR |
| Solvents | water, DMSO |
| Fluorescence | λex 364 nm, λem 476 nm in 0.1 M phosphate pH 7.0 |
| Smiles | CC(=O)NC1=CC=C2C(=O)N(CC(O)=O)C(=O)C3=C2C1=CC=C3 |
| InChi Key | RCZAYEHQRFPFSH-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) K. Misra et al.: Radiobiol. Bio-Med. Res. 129 (2004), (2) R.W. Odd et al.: Blackwell Scientific Publication, 317 (1992), (3) R.J. Kaiser et al.: Nucleic Acids Research 17, 6087 (1989) |
| InChi | InChI=1S/C20H20N2O5/c1-12(23)21-16-10-9-15-18-13(16)6-5-7-14(18)19(26)22(20(15)27)11-4-2-3-8-17(24)25/h5-7,9-10H,2-4,8,11H2,1H3,(H,21,23)(H,24,25) |
| Quantity | 10 mg, 50 mg, Bulk |
