6-(4-Acetamido-1,8-naphthalamido) hexanoic acid

Specifications

Purity

≥95% (HPCE)

Appearance

Solid

Identity

1H-NMR

Properties

Fluorescence

λex 364 nm, λem 476 nm in 0.1 M phosphate pH 7.0

Solvents

water, DMSO

Downloads

Safety Data Sheet

CDX A0038 MSDS.pdf

Short Term Storage

+4°C

Use / Stability

Stable for at least 2 years after receipt when stored at -20°C.

Handling Advice

Protect from light and moisture.

Long Term Storage

-20°C

Shipping

AMBIENT

Transportation

Not dangerous goods

Description

The highly fluorescent label 4-acetylamino-1,8-naphthalimide-N-caproic acid has two fused benzene rings containing a closed anhydride ring and therefore is a flat and planar molecule which can easily intercalate or act as a groove binder with DNA/RNA sequences. For the study of in situ hydridization with complementary synthetic oligonucleotides (ODNs), tagging with non-radioactive labels has gained importance, not only for medical diagnostics or clinical genetics, but also detection and isolation of DNA for research purposes. The pentamethylene chain in 6 acts as a linker molecule and keeps the target at a reasonable distance to avoid direct interaction with oligonucleotides.

InChi

InChI=1S/C20H20N2O5/c1-12(23)21-16-10-9-15-18-13(16)6-5-7-14(18)19(26)22(20(15)27)11-4-2-3-8-17(24)25/h5-7,9-10H,2-4,8,11H2,1H3,(H,21,23)(H,24,25)

References

(1) K. Misra et al.: Radiobiol. Bio-Med. Res. 129 (2004) , (2) R.W. Odd et al.: Blackwell Scientific Publication, 317 (1992) , (3) R.J. Kaiser et al.: Nucleic Acids Research 17, 6087 (1989)

InChi Key

RCZAYEHQRFPFSH-UHFFFAOYSA-N

Smiles

CC(=O)NC1=CC=C2C(=O)N(CC(O)=O)C(=O)C3=C2C1=CC=C3