- Purity: ≥95% (HPCE)
- Appearance: Solid.
- CAS-Number: 172227-59-7
- Molecular Formula: C20H20N2O5
- Molecular Weight: 368.38
- Identity: 1H-NMR
- Solvents: water, DMSO
- Fluorescence: λex 364 nm; λem 476 nm in 0.1 M phosphate pH 7.0
- Smiles: CC(=O)NC1=CC=C2C(=O)N(CC(O)=O)C(=O)C3=C2C1=CC=C3
- InChi: InChI=1S/C20H20N2O5/c1-12(23)21-16-10-9-15-18-13(16)6-5-7-14(18)19(26)22(20(15)27)11-4-2-3-8-17(24)25/h5-7,9-10H,2-4,8,11H2,1H3,(H,21,23)(H,24,25)
- InChi Key: RCZAYEHQRFPFSH-UHFFFAOYSA-N
Available from stock
6-(4-Acetamido-1,8-naphthalamido) hexanoic acid
SKU: A0038
Category: Fluorescent Detection
- Shipping: AMBIENT
- Short Term Storage: +4°C
- Long Term Storage: -20°C
- Handling Advice: Protect from light and moisture.
- Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
- Description: The highly fluorescent label 4-acetylamino-1,8-naphthalimide-N-caproic acid has two fused benzene rings containing a closed anhydride ring and therefore is a flat and planar molecule which can easily intercalate or act as a groove binder with DNA/RNA sequences. For the study of in situ hydridization with complementary synthetic oligonucleotides (ODNs), tagging with non-radioactive labels has gained importance, not only for medical diagnostics or clinical genetics, but also detection and isolation of DNA for research purposes. The pentamethylene chain in 6 acts as a linker molecule and keeps the target at a reasonable distance to avoid direct interaction with oligonucleotides.
- References: (1) K. Misra et al.; Radiobiol. Bio-Med. Res. 129 (2004), (2) R.W. Odd et al.; Blackwell Scientific Publication, 317 (1992), (3) R.J. Kaiser et al.; Nucleic Acids Research 17, 6087 (1989)
The highly fluorescent label 4-acetylamino-1,8-naphthalimide-N-caproic acid has two fused benzene rings containing a closed anhydride ring and therefore is a flat and planar molecule which can easily intercalate or act as a groove binder with DNA/RNA sequences. For the study of in situ hydridization with complementary synthetic oligonucleotides (ODNs), tagging with non-radioactive labels has gained importance, not only for medical diagnostics or clinical genetics, but also detection and isolation of DNA for research purposes. The pentamethylene chain in 6 acts as a linker molecule and keeps the target at a reasonable distance to avoid direct interaction with oligonucleotides.
Additional information
| Quantity | 10 mg, 50 mg, Bulk |
|---|---|
| Handling Advice | Protect from light and moisture. |
| Availability | 1 |
| CAS-Number | 172227-59-7 |
| Identity | 1H-NMR |
| Long Term Storage | -20°C |
| Appearance | Solid. |
| InChi | InChI=1S/C20H20N2O5/c1-12(23)21-16-10-9-15-18-13(16)6-5-7-14(18)19(26)22(20(15)27)11-4-2-3-8-17(24)25/h5-7,9-10H,2-4,8,11H2,1H3,(H,21,23)(H,24,25) |
| InChi Key | RCZAYEHQRFPFSH-UHFFFAOYSA-N |
| Fluorescence | λex 364 nm; λem 476 nm in 0.1 M phosphate pH 7.0 |
| Molecular Formula | |
| Shipping | AMBIENT |
| Purity | |
| Pricetable | |
| References | (1) K. Misra et al.; Radiobiol. Bio-Med. Res. 129 (2004), (2) R.W. Odd et al.; Blackwell Scientific Publication, 317 (1992), (3) R.J. Kaiser et al.; Nucleic Acids Research 17, 6087 (1989) |
| Short Term Storage | +4°C |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Molecular Weight | |
| Smiles | CC(=O)NC1=CC=C2C(=O)N(CC(O)=O)C(=O)C3=C2C1=CC=C3 |
| Solvents | water, DMSO |
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