Specifications
- Purity
- ≥97% (NMR)
- Appearance
- White to yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in acetonitrile or water.
Category: Building Blocks, Intermediates, Reagents
1-Cyano-4-(dimethylamino)pyridinium tetrafluoroborate (CDAP) is an organic highly effective water soluble cyanylation reagent for protein sulfhydryl groups and used to prepare protein-polysaccharide conjugates. It is employed as an activating agent for polysaccharide resins and conjugation of lipopolysaccharides while retaining endotoxic activity. The activation and further carbohydrate modification are produced under mild conditions in an aqueous solvent, an enzyme friendly environment. CDAP can be used with alkaline-sensitive polysaccharides and proteins.
Synonyms | CDAP |
---|---|
Purity | ≥97% (NMR) |
Appearance | White to yellow powder |
CAS-Number | 59016-56-7 |
Molecular Formula | C8H10N3.BF4 |
Molecular Weight | 235.0 |
Identity | 1H-NMR |
Solvents | Soluble in acetonitrile or water. |
Smiles | CN(C)C1=CC=[N+](C#N)C=C1.FB(F)F.[F] |
InChi Key | ONCRRSYBEJHQMM-UHFFFAOYSA-M |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H314 – H335 |
Precautionary statements | P260 – P271 – P280 – P301 + P330 + P331 – P303 + P361 + P353 – P305 + P351 + P338 |
GHS Symbol | GHS05+GHS07 |
Signal word | Danger |
RIDADR | UN3263 |
Transportation | Packing Group II |
References | (1) J. Kohn & M. Wilchek, FEBS Lett. 154, 209 (1983), (2) A. Lees, et al., Vaccine 14, 190 (1996), (3) S. Bystricky, et al., Glycoconj. J. 17, 677 (2000), (4) F. Battaglini & D. Pallarola, Meth. Prot. Meth. Mol. Biol. 739, 161 (2011), (5) A. Lees, et al., Vaccines 8, 777 (2020) |
InChi | InChI=1S/C8H10N3.BF3.FH/c1-10(2)8-3-5-11(7-9)6-4-8;2-1(3)4;/h3-6H,1-2H3;;1H/q+1;;/p-1 |
Quantity | 100 mg, 500 mg, Bulk |