BEP

SKU: B0040

Category: Building Blocks, Intermediates, Reagents

Synonyms: 2-Bromo-1-ethyl-pyridinium tetrafluoroborate; 878-23-9
CAS-Number: C₇H₉BrNBF₄
Molecular Formula: 273.86
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (Titration)
Identity: 1H-NMR
Appearance: White powder

Properties

Melting Point: 102-104 °C
Solvents: water

Shipping: AMBIENT
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: -20°C
Short Term Storage: +4°C

Transportation: Not dangerous goods

Description: Efficient coupling reagent for the synthesis of sterically hindered amides, especially peptides. In terms of reactivity and racemization-suppressing capability, this pyridinium-type reagent, BEP, proved to be more efficient than commonly used uronium- and phosphonium-type reagents, such as HBTU, BOP, and PyBroP, for the synthesis of hindered peptides containing N-methylated or C?,C?-dialkylated amino acid residues. BEP was also proven to be an efficient reagent for the synthesis of esters, especially active esters and hindered esters, and tert-butyl esters.
InChi: InChI=1S/C7H9BrN.BF4/c1-2-9-6-4-3-5-7(9)8
InChi Key: YJDXVQLBIAJTHP-UHFFFAOYSA-N
Smiles: CC[N]1=C(Br)C=CC=C1.FB(F)F.[F-]

Efficient coupling reagent for the synthesis of sterically hindered amides, especially peptides. In terms of reactivity and racemization-suppressing capability, this pyridinium-type reagent, BEP, proved to be more efficient than commonly used uronium- and phosphonium-type reagents, such as HBTU, BOP, and PyBroP, for the synthesis of hindered peptides containing N-methylated or C?,C?-dialkylated amino acid residues. BEP was also proven to be an efficient reagent for the synthesis of esters, especially active esters and hindered esters, and tert-butyl esters.

SKU: B0040 Category: Building Blocks, Intermediates, Reagents

Additional information

Additional information

Synonyms	2-Bromo-1-ethyl-pyridinium tetrafluoroborate
Purity	≥97% (Titration)
Appearance	White powder
CAS-Number	878-23-9
Molecular Formula	C7H9BrNBF4
Molecular Weight	273.86
Identity	1H-NMR
Solvents	water
Melting Point	102-104 °C
Smiles	CC[N]1=C(Br)C=CC=C1.FB(F)F.[F-]
InChi Key	YJDXVQLBIAJTHP-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
InChi	InChI=1S/C7H9BrN.BF4/c1-2-9-6-4-3-5-7(9)8
Quantity	1 g, 5 g, 25 g, Bulk