Specifications
- Purity
- ≥98% (TLC)
- Appearance
- Yellow to orange powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, methanol, ethanol or water (slightly)
- Melting Point
- 214 °C
Downloads
- Safety Data Sheet
- CDX B0212 MSDS.pdf
Category: Phytochemicals
Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetics, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK.
Synonyms | Natural Yellow 18, Berberinium chloride, BBR, Umbellatine |
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Purity | ≥98% (TLC) |
Appearance | Yellow to orange powder |
CAS-Number | 633-65-8 |
Molecular Formula | C20H17NO4 . HCl |
Molecular Weight | 371.81 |
Identity | 1H-NMR |
Solvents | DMSO, methanol, ethanol or water (slightly) |
Melting Point | 214 °C |
Smiles | COC1=C(OC)C=CC2=CC(C3=CC4=C(OCO4)C=C3CC5)=[N+]5C=C12.[Cl-] |
InChi Key | VKJGBAJNNALVAV-UHFFFAOYSA-M |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) P.J. Kaboli, et al.: Eur. J. Pharmacol. 740, 584 (2014), (2) L.M. Ortiz, et al.: Molecules 19, 12349 (2014), (3) W.J. Ni, et al.: Eur. J. Pharmacol. 760, 103 (2015) |
InChi | InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2 |
Quantity | 10 g, 25 g, 50 g, Bulk |