Specifications
- Purity
- ≥98% (GC)
- Appearance
- White to light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- chloroform, DMSO
- Melting Point
- 194-197 °C (lit.)
- Boiling Point
- 275 °C (lit.)
Available from stock
Dichlone
- SKU
- D0641
Category: Fungicides
- Synonyms
- 2,3-Dichloro-1,4-naphthoquinone, CNQ, Dichlon, NSC 537, USR 604
- 117-80-6
- CAS-Number
- C10H4Cl2O2
- Molecular Formula
- 227.04
- Molecular Weight
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 6 months after receipt when stored at RT.
- Hazard statements
- H301-H315-H319-H410
- Precautionary statements
- P264-P270-P273-P301+P310-P302+P352-P305+P351+P338
- GHS Symbol
- GHS07+GHS09
- Signal word
- Danger
- RIDADR
- UN2811
- Transportation
- Packing Group III
- For Research Use Only
- Not Intended for Diagnostic or Therapeutic Use.
- Description
- Dichlone is a naphthoquinone derivative and is widely used in various applications, particularly as a pesticide (fungicide and algicide). This compound can be used as an analytical reference. Dichlone shows several biological properties. It is a potent redox mediator, inducing oxidative stress, has been shown to inhibit ryanodine receptors and acts as a potent DNA methylation inhibitor (EC50=460nM against Dnmt3A/3L catalytic complex). Dichlone is also used as an organic catalyst or as chemical intermediate for synthetic procedures (dyes, pigments) or for spectrophotometric analysis of primary aliphatic amines.
- Smiles
- ClC1=C(Cl)C(=O)c2ccccc2C1=O
- InChi Key
- SVPKNMBRVBMTLB-UHFFFAOYSA-N
- References
- (1) A.A. Abou-Ouf, et al., J. Pharm. Sci. 62, 1700 (1973) , (2) H.C. Sikka, et al., Chem. Biol. Interact. 9, 261 (1974) , (3) C.A. Pritsos, et al., Arch. Biochem. Biophys. 217, 98 (1982) , (4) F.A. El-Yazbi, et al., J. Pharm. Biomed. Anal. 19, 819 (1999) , (5) C. Morisseau, et al., Environ Health Perspect. 117, 1867 (2009) , (6) P.P. Vaughan, et al., Photochem. Photobiol. 86, 1327 (2010) , (7) A. Ceccaldi, et al., ACS Chem. Biol. 8, 543 (2013) , (8) T.S. Belal, et al., Spectrochim. Acta A Mol. Biomol. Spectrosc. 155, 47 (2016) , (9) A.A. Petrova, et al., FEBS Lett. 592, 2220 (2018)
- InChi
- InChI=1S/C10H4Cl2O2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4H
Dichlone is a naphthoquinone derivative and is widely used in various applications, particularly as a pesticide (fungicide and algicide). This compound can be used as an analytical reference. Dichlone shows several biological properties. It is a potent redox mediator, inducing oxidative stress, has been shown to inhibit ryanodine receptors and acts as a potent DNA methylation inhibitor (EC50=460nM against Dnmt3A/3L catalytic complex). Dichlone is also used as an organic catalyst or as chemical intermediate for synthetic procedures (dyes, pigments) or for spectrophotometric analysis of primary aliphatic amines.
Additional information
| Synonyms | 2,3-Dichloro-1,4-naphthoquinone, CNQ, Dichlon, NSC 537, USR 604 |
|---|---|
| Purity | ≥98% (GC) |
| Appearance | White to light yellow powder |
| CAS-Number | 117-80-6 |
| Molecular Formula | C10H4Cl2O2 |
| Molecular Weight | 227.04 |
| Identity | 1H-NMR |
| Solvents | chloroform, DMSO |
| Melting Point | 194-197 °C (lit.) |
| Boiling Point | 275 °C (lit.) |
| Smiles | ClC1=C(Cl)C(=O)c2ccccc2C1=O |
| InChi Key | SVPKNMBRVBMTLB-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 6 months after receipt when stored at RT. |
| Hazard statements | H301-H315-H319-H410 |
| Precautionary statements | P264-P270-P273-P301+P310-P302+P352-P305+P351+P338 |
| GHS Symbol | GHS07+GHS09 |
| Signal word | Danger |
| RIDADR | UN2811 |
| Transportation | Packing Group III |
| References | (1) A.A. Abou-Ouf, et al., J. Pharm. Sci. 62, 1700 (1973), (2) H.C. Sikka, et al., Chem. Biol. Interact. 9, 261 (1974), (3) C.A. Pritsos, et al., Arch. Biochem. Biophys. 217, 98 (1982), (4) F.A. El-Yazbi, et al., J. Pharm. Biomed. Anal. 19, 819 (1999), (5) C. Morisseau, et al., Environ Health Perspect. 117, 1867 (2009), (6) P.P. Vaughan, et al., Photochem. Photobiol. 86, 1327 (2010), (7) A. Ceccaldi, et al., ACS Chem. Biol. 8, 543 (2013), (8) T.S. Belal, et al., Spectrochim. Acta A Mol. Biomol. Spectrosc. 155, 47 (2016), (9) A.A. Petrova, et al., FEBS Lett. 592, 2220 (2018) |
| InChi | InChI=1S/C10H4Cl2O2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4H |
| Quantity | 100 mg, Bulk |
