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    Difluoromethyl phenyl sulfone

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    Difluoromethyl phenyl sulfone

    SKU
    D0401

    Category: Building Blocks, Intermediates, Reagents

    Synonyms
    Phenyl difluoromethyl sulfone
    1535-65-5
    CAS-Number
    C7H6F2O2S
    Molecular Formula
    192.2
    Molecular Weight

    • Product Data
    • Handling
    • Safety Information
    • Details

    Specifications

    Purity
    ≥98% (HPLC)
    Identity
    1H-NMR
    Appearance
    Colorless to light yellow semi-solid

    Properties

    Solvents
    chloroform, DMSO

    Downloads

    Safety Data Sheet
    CDX D0401 MSDS.pdf
    Handling Advice
    Protect from light and moisture.
    Use / Stability
    Stable for at least 2 years after receipt when stored at -20°C.
    Long Term Storage
    -20°C
    Short Term Storage
    +4°C
    Shipping
    AMBIENT
    Transportation
    Not dangerous goods
    Signal word
    Warning
    GHS Symbol
    GHS07
    Precautionary statements
    P261-P305 + P351 + P338
    Hazard statements
    H315-H319-H335
    Description
    Building block for synthesis. Has been used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of alpha,beta-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of alpha-difluoromethyl amines, anti-difluoropropanediols, beta-difluoromethylated and beta-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.
    InChi
    InChI=1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H
    References
    (1) G.K.S. Prakash, et al.: J. Org. Chem. 68, 4457 (2003) , (2) G.K.S. Prakash, et al.: Angew. Chem. 42, 5216 (2003) , (3) G.K.S. Prakash, et al.: Angew. Chem. 43, 5203 (2004) , (4) G.K.S. Prakash, et al.: Org. Lett. 6, 4315 (2004) , (5) Y. Li & J. Hu: Angew. Chem. 44, 5882 (2005) , (6) G.K.S. Prakash, et al.: Europ. J. Org. Chem. 11, 2218 (2005) , (7) C. Ni, et al.: Angew. Chem. 46, 786 (2007) , (8) J. Liu, et al.: J. Org. Chem. 72, 3119 (2007) , (9) C. Ni, et al.: J. Org. Chem. 73, 5699 (2008) , (10) M. Hu, et al.: J. Fluor. Chem. 155, 52 (2013)
    InChi Key
    LRHDNAVPELLXDL-UHFFFAOYSA-N
    Smiles
    FC(F)S(=O)(=O)C1=CC=CC=C1

    Building block for synthesis. Has been used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of alpha,beta-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of alpha-difluoromethyl amines, anti-difluoropropanediols, beta-difluoromethylated and beta-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.

    SKU: D0401 Category: Building Blocks, Intermediates, Reagents
    • Additional information

    Additional information

    Synonyms

    Phenyl difluoromethyl sulfone

    Purity

    ≥98% (HPLC)

    Appearance

    Colorless to light yellow semi-solid

    CAS-Number

    1535-65-5

    Molecular Formula

    C7H6F2O2S

    Molecular Weight

    192.2

    Identity

    1H-NMR

    Solvents

    chloroform, DMSO

    Smiles

    FC(F)S(=O)(=O)C1=CC=CC=C1

    InChi Key

    LRHDNAVPELLXDL-UHFFFAOYSA-N

    Shipping

    AMBIENT

    Short Term Storage

    +4°C

    Long Term Storage

    -20°C

    Handling Advice

    Protect from light and moisture.

    Use / Stability

    Stable for at least 2 years after receipt when stored at -20°C.

    Hazard statements

    H315-H319-H335

    Precautionary statements

    P261-P305 + P351 + P338

    GHS Symbol

    GHS07

    Signal word

    Warning

    Transportation

    Not dangerous goods

    References

    (1) G.K.S. Prakash, et al.: J. Org. Chem. 68, 4457 (2003), (2) G.K.S. Prakash, et al.: Angew. Chem. 42, 5216 (2003), (3) G.K.S. Prakash, et al.: Angew. Chem. 43, 5203 (2004), (4) G.K.S. Prakash, et al.: Org. Lett. 6, 4315 (2004), (5) Y. Li & J. Hu: Angew. Chem. 44, 5882 (2005), (6) G.K.S. Prakash, et al.: Europ. J. Org. Chem. 11, 2218 (2005), (7) C. Ni, et al.: Angew. Chem. 46, 786 (2007), (8) J. Liu, et al.: J. Org. Chem. 72, 3119 (2007), (9) C. Ni, et al.: J. Org. Chem. 73, 5699 (2008), (10) M. Hu, et al.: J. Fluor. Chem. 155, 52 (2013)

    InChi

    InChI=1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H

    Quantity

    2.5 g, 10 g, Bulk

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