Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Colorless to light yellow semi-solid
- Identity
- 1H-NMR
Properties
- Solvents
- chloroform, DMSO
Documentation
- Safety Data Sheet (SDS)
- CDX D0401 MSDS.pdf
Available from stock
Difluoromethyl phenyl sulfone
- SKU
- D0401
Category: Building Blocks, Intermediates, Reagents
- Synonyms
- Phenyl difluoromethyl sulfone
- 1535-65-5
- CAS-Number
- C7H6F2O2S
- Molecular Formula
- 192.2
- Molecular Weight
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P305 + P351 + P338
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Building block for synthesis. Has been used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of alpha,beta-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of alpha-difluoromethyl amines, anti-difluoropropanediols, beta-difluoromethylated and beta-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.
- Smiles
- FC(F)S(=O)(=O)C1=CC=CC=C1
- InChi Key
- LRHDNAVPELLXDL-UHFFFAOYSA-N
- References
- (1) G.K.S. Prakash, et al.: J. Org. Chem. 68, 4457 (2003) , (2) G.K.S. Prakash, et al.: Angew. Chem. 42, 5216 (2003) , (3) G.K.S. Prakash, et al.: Angew. Chem. 43, 5203 (2004) , (4) G.K.S. Prakash, et al.: Org. Lett. 6, 4315 (2004) , (5) Y. Li & J. Hu: Angew. Chem. 44, 5882 (2005) , (6) G.K.S. Prakash, et al.: Europ. J. Org. Chem. 11, 2218 (2005) , (7) C. Ni, et al.: Angew. Chem. 46, 786 (2007) , (8) J. Liu, et al.: J. Org. Chem. 72, 3119 (2007) , (9) C. Ni, et al.: J. Org. Chem. 73, 5699 (2008) , (10) M. Hu, et al.: J. Fluor. Chem. 155, 52 (2013)
- InChi
- InChI=1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H
Building block for synthesis. Has been used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of alpha,beta-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of alpha-difluoromethyl amines, anti-difluoropropanediols, beta-difluoromethylated and beta-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.
Additional information
| Synonyms | Phenyl difluoromethyl sulfone |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | Colorless to light yellow semi-solid |
| CAS-Number | 1535-65-5 |
| Molecular Formula | C7H6F2O2S |
| Molecular Weight | 192.2 |
| Identity | 1H-NMR |
| Solvents | chloroform, DMSO |
| Smiles | FC(F)S(=O)(=O)C1=CC=CC=C1 |
| InChi Key | LRHDNAVPELLXDL-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305 + P351 + P338 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) G.K.S. Prakash, et al.: J. Org. Chem. 68, 4457 (2003), (2) G.K.S. Prakash, et al.: Angew. Chem. 42, 5216 (2003), (3) G.K.S. Prakash, et al.: Angew. Chem. 43, 5203 (2004), (4) G.K.S. Prakash, et al.: Org. Lett. 6, 4315 (2004), (5) Y. Li & J. Hu: Angew. Chem. 44, 5882 (2005), (6) G.K.S. Prakash, et al.: Europ. J. Org. Chem. 11, 2218 (2005), (7) C. Ni, et al.: Angew. Chem. 46, 786 (2007), (8) J. Liu, et al.: J. Org. Chem. 72, 3119 (2007), (9) C. Ni, et al.: J. Org. Chem. 73, 5699 (2008), (10) M. Hu, et al.: J. Fluor. Chem. 155, 52 (2013) |
| InChi | InChI=1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H |
| Quantity | 2.5 g, 10 g, Bulk |
