Difluoromethyl phenyl sulfone

SKU: D0401

Category: Building Blocks, Intermediates, Reagents

Synonyms: Phenyl difluoromethyl sulfone; 1535-65-5
CAS-Number: C₇H₆F₂O₂S
Molecular Formula: 192.2
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: Colorless to light yellow semi-solid

Properties

Solvents: chloroform, DMSO

Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Long Term Storage: -20°C
Short Term Storage: +4°C
Shipping: AMBIENT

Transportation: Not dangerous goods
Signal word: Warning
GHS Symbol: GHS07
Precautionary statements: P261-P305 + P351 + P338
Hazard statements: H315-H319-H335

Description: Building block for synthesis. Has been used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of alpha,beta-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of alpha-difluoromethyl amines, anti-difluoropropanediols, beta-difluoromethylated and beta-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.
InChi: InChI=1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H
References: (1) G.K.S. Prakash, et al.: J. Org. Chem. 68, 4457 (2003) , (2) G.K.S. Prakash, et al.: Angew. Chem. 42, 5216 (2003) , (3) G.K.S. Prakash, et al.: Angew. Chem. 43, 5203 (2004) , (4) G.K.S. Prakash, et al.: Org. Lett. 6, 4315 (2004) , (5) Y. Li & J. Hu: Angew. Chem. 44, 5882 (2005) , (6) G.K.S. Prakash, et al.: Europ. J. Org. Chem. 11, 2218 (2005) , (7) C. Ni, et al.: Angew. Chem. 46, 786 (2007) , (8) J. Liu, et al.: J. Org. Chem. 72, 3119 (2007) , (9) C. Ni, et al.: J. Org. Chem. 73, 5699 (2008) , (10) M. Hu, et al.: J. Fluor. Chem. 155, 52 (2013)
InChi Key: LRHDNAVPELLXDL-UHFFFAOYSA-N
Smiles: FC(F)S(=O)(=O)C1=CC=CC=C1

Building block for synthesis. Has been used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of alpha,beta-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of alpha-difluoromethyl amines, anti-difluoropropanediols, beta-difluoromethylated and beta-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.

SKU: D0401 Category: Building Blocks, Intermediates, Reagents

Additional information

Additional information

Synonyms	Phenyl difluoromethyl sulfone
Purity	≥98% (HPLC)
Appearance	Colorless to light yellow semi-solid
CAS-Number	1535-65-5
Molecular Formula	C7H6F2O2S
Molecular Weight	192.2
Identity	1H-NMR
Solvents	chloroform, DMSO
Smiles	FC(F)S(=O)(=O)C1=CC=CC=C1
InChi Key	LRHDNAVPELLXDL-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305 + P351 + P338
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) G.K.S. Prakash, et al.: J. Org. Chem. 68, 4457 (2003), (2) G.K.S. Prakash, et al.: Angew. Chem. 42, 5216 (2003), (3) G.K.S. Prakash, et al.: Angew. Chem. 43, 5203 (2004), (4) G.K.S. Prakash, et al.: Org. Lett. 6, 4315 (2004), (5) Y. Li & J. Hu: Angew. Chem. 44, 5882 (2005), (6) G.K.S. Prakash, et al.: Europ. J. Org. Chem. 11, 2218 (2005), (7) C. Ni, et al.: Angew. Chem. 46, 786 (2007), (8) J. Liu, et al.: J. Org. Chem. 72, 3119 (2007), (9) C. Ni, et al.: J. Org. Chem. 73, 5699 (2008), (10) M. Hu, et al.: J. Fluor. Chem. 155, 52 (2013)
InChi	InChI=1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H
Quantity	2.5 g, 10 g, Bulk