Specifications
- Purity
- ≥97% (T)
- Appearance
- Off-white to beige powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in DMSO.
- Density
- 1.26g/cm3
Category: Building Blocks, Intermediates, Reagents
Hydrocupreine (6′-Hydroxydihydrocinchonidine) is a derivative of cinchonidine and metabolite of quinine, alkaloids found in the bark of the Cinchona tree. It has been shown to have antimicrobial and antitumor activity, and inhibitory effect on Trypanosoma brucei and Streptococcus pneumoniae. Hydrocupreine can be used as a building block, starting material or reagent in organic synthesis to create more complex chiral chemical compounds and/or azo dyes. It has been used in organocatalaysis and during Friedel-Crafts amination.
Synonyms | 6'-Hydroxydihydrocinchonidine, O6?-Demethylhydroquinine |
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Purity | ≥97% (T) |
Appearance | Off-white to beige powder |
CAS-Number | 5962-19-6 |
Molecular Formula | C19H24N2O2 |
Molecular Weight | 312.41 |
Identity | 1H-NMR |
Solvents | Soluble in DMSO. |
Density | 1.26g/cm3 |
Smiles | CCC1CN2CCC1CC2C(C3=C4C=C(C=CC4=NC=C3)O)O |
InChi Key | RASAUPYEBCYZRS-BIPCEHGGSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H302-H315-H319 |
Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313- |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) M. Heidelberger & W.A. Jacobs, JACS 41, 1881 (1919), (2) S. Brandes, et al., Ang. Chem. Int. Ed. 45, 1147 (2006), (3) S. Brandes, et al., Chem. Eur. J. 12, 6039 (2006), (4) G. Dickmeiss, et al., Ang. Chem. Int. Ed. 48, 6650 (2009), (5) K. Kacprzak, et al., Chem. Biol. Drug Des. 92, 1778 (2018), (6) X. Wu, et al., J. Med. Chem. 62, 2305 (2019) |
Quantity | 1 g, 5 g, Bulk |