Specifications
- Purity
- ≥98% (NMR)
- Appearance
- Orange liquid
- Identity
- 1H-NMR
Properties
- Solvents
- Slightly soluble in DMSO, methanol, ethanol or chloroform.
Available from stock
N-Nitrosomethylphenylamine (NMPA)
- SKU
- N0372
Category: Building Blocks, Intermediates, Reagents
- Synonyms
- NMPA, N-Methyl-N-nitrosoaniline, N-Methyl-N-nitrosobenzenamine, N-Methyl-N-phenylnitrosamine, NSC137
- 614-00-6
- CAS-Number
- C7H8N2O
- Molecular Formula
- 136.15
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H225 - H301 + H311 + H331 - H370
- Precautionary statements
- P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
- GHS Symbol
- GHS02+GHS06+GHS08
- Signal word
- Danger
- RIDADR
- UN2810
- Transportation
- Packing Group III
- Description
- N-nitrosomethylphenylamine (NMPA) is a nitrosamine and is known to be a potent carcinogen associated with cancer development in animals and humans. NMPA can damage DNA and cause mutations in genes that control cell growth and division. It reacts with DNA in vitro to form genotoxic activity, which may lead to cell death or mutagenesis. NMPA is formed in various industrial processes, including the synthesis of certain chemicals. It serves as a building block in the synthesis of diverse compounds and functions as an analytical reagent for environmental monitoring. This compound can be used as analytical reference material. NMPA is useful for studying enzymatic denitrosation processes. NMPA could be used as a tumor initiator, as a reagent for preparing carcinogenic animal diseases moδ
- InChi Key
- MAXCWSIJKVASQC-UHFFFAOYSA-N
- References
- (1) C.M. Goodall, et al., Toxicol. Appl. Pharmacol. 17, 426 (1970) , (2) W. Lijinsky & R.M. Kovatch, Cancer Res. 48, 6648 (1988) , (3) S.R. Koepke, et al., IARC Sci. Publ. 105, 346 (1991) , (4) T. Scheper, et al., Chem. Biol. Interact. 77, 81 (1991) , (5) M. Stiborova, et al., Cancer Lett. 110, 11 (1996) , (6) M. Stiborova, et al., Cancer Lett. 138, 61 (1999) , (7) Y. Li & S.S. Hecht, Int. J. Mol. Sci. 23, 4559 (2022) , (8) M. Bignami, et al., Efsa J. 21, e07884 (2023)
N-nitrosomethylphenylamine (NMPA) is a nitrosamine and is known to be a potent carcinogen associated with cancer development in animals and humans. NMPA can damage DNA and cause mutations in genes that control cell growth and division. It reacts with DNA in vitro to form genotoxic activity, which may lead to cell death or mutagenesis. NMPA is formed in various industrial processes, including the synthesis of certain chemicals. It serves as a building block in the synthesis of diverse compounds and functions as an analytical reagent for environmental monitoring. This compound can be used as analytical reference material. NMPA is useful for studying enzymatic denitrosation processes. NMPA could be used as a tumor initiator, as a reagent for preparing carcinogenic animal diseases moδ
Additional information
| Synonyms | NMPA, N-Methyl-N-nitrosoaniline, N-Methyl-N-nitrosobenzenamine, N-Methyl-N-phenylnitrosamine, NSC137 |
|---|---|
| Purity | ≥98% (NMR) |
| Appearance | Orange liquid |
| CAS-Number | 614-00-6 |
| Molecular Formula | C7H8N2O |
| Molecular Weight | 136.15 |
| Identity | 1H-NMR |
| Solvents | Slightly soluble in DMSO, methanol, ethanol or chloroform. |
| InChi Key | MAXCWSIJKVASQC-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H225 – H301 + H311 + H331 – H370 |
| Precautionary statements | P210 – P233 – P280 – P301 + P310 – P303 + P361 + P353 – P304 + P340 + P311 |
| GHS Symbol | GHS02+GHS06+GHS08 |
| Signal word | Danger |
| RIDADR | UN2810 |
| Transportation | Packing Group III |
| References | (1) C.M. Goodall, et al., Toxicol. Appl. Pharmacol. 17, 426 (1970), (2) W. Lijinsky & R.M. Kovatch, Cancer Res. 48, 6648 (1988), (3) S.R. Koepke, et al., IARC Sci. Publ. 105, 346 (1991), (4) T. Scheper, et al., Chem. Biol. Interact. 77, 81 (1991), (5) M. Stiborova, et al., Cancer Lett. 110, 11 (1996), (6) M. Stiborova, et al., Cancer Lett. 138, 61 (1999), (7) Y. Li & S.S. Hecht, Int. J. Mol. Sci. 23, 4559 (2022), (8) M. Bignami, et al., Efsa J. 21, e07884 (2023) |
| Quantity | 1 g, Bulk |
