Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder or crystals
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, DMF, ethanol or methanol (all 10mg/ml), water (insoluble)
Available from stock
1-Hydroxyibuprofen
- SKU
- H0943
Category: API's & Intermediates
- Synonyms
- Ibuprofen Impurity L, Ibuprofen EP Impurity L, 2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic acid, 1-OH IBU
- 53949-53-4
- CAS-Number
- C13H18O3
- Molecular Formula
- 222.28
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H302
- Precautionary statements
- P264 - P270 - P301 + P312 - P501
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- The metabolite 1-Hydroxyibuprofen (Ibuprofen Impurity L) is a degradation product of Ibuprofen which is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain from various conditions such as headache, dental pain or menstrual cramps. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2. Ibuprofen is metabolized in the human liver to a number of metabolites including 1-hydroxyibuprofen (1-OH-Ibu), 2-OH-Ibu and 3-OH-Ibu, respectively. 1-Hydroxyibuprofen was determined as the dominant compound in soils. This product can be used as a working standard or secondary analytical reference standard.
- Smiles
- CC(C)C(O)c1ccc(cc1)C(C)C(O)=O
- InChi Key
- RMOQYHYFRKTDRI-UHFFFAOYSA-N
- References
- (1) I. Neunzig, et al., J. Biotechnol. 157, 417 (2012) , (2) Z. Han, et al., Chromatographia 80, 1353 (2017) , (3) E. Waraksa, et al., J. Pharm. Biomed. Anal. 152, 279 (2018) , (4) T. Dolu & B. Nas, Environ. Res. 227, 115731 (2023)
- InChi
- InChI=1S/C13H18O3/c1-8(2)12(14)11-6-4-10(5-7-11)9(3)13(15)16/h4-9,12,14H,1-3H3,(H,15,16)
The metabolite 1-Hydroxyibuprofen (Ibuprofen Impurity L) is a degradation product of Ibuprofen which is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain from various conditions such as headache, dental pain or menstrual cramps. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2. Ibuprofen is metabolized in the human liver to a number of metabolites including 1-hydroxyibuprofen (1-OH-Ibu), 2-OH-Ibu and 3-OH-Ibu, respectively. 1-Hydroxyibuprofen was determined as the dominant compound in soils. This product can be used as a working standard or secondary analytical reference standard.
Additional information
| Synonyms | Ibuprofen Impurity L, Ibuprofen EP Impurity L, 2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic acid, 1-OH IBU |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white powder or crystals |
| CAS-Number | 53949-53-4 |
| Molecular Formula | C13H18O3 |
| Molecular Weight | 222.28 |
| Identity | 1H-NMR |
| Solvents | DMSO, DMF, ethanol or methanol (all 10mg/ml), water (insoluble) |
| Smiles | CC(C)C(O)c1ccc(cc1)C(C)C(O)=O |
| InChi Key | RMOQYHYFRKTDRI-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H302 |
| Precautionary statements | P264 – P270 – P301 + P312 – P501 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) I. Neunzig, et al., J. Biotechnol. 157, 417 (2012), (2) Z. Han, et al., Chromatographia 80, 1353 (2017), (3) E. Waraksa, et al., J. Pharm. Biomed. Anal. 152, 279 (2018), (4) T. Dolu & B. Nas, Environ. Res. 227, 115731 (2023) |
| InChi | InChI=1S/C13H18O3/c1-8(2)12(14)11-6-4-10(5-7-11)9(3)13(15)16/h4-9,12,14H,1-3H3,(H,15,16) |
| Quantity | 10 mg, Bulk |
