Available from stock

N-nitrosopyrrolidine (NPYR)

SKU: N0378

Category: Building Blocks, Intermediates, Reagents

Synonyms: NPYR, NSC 18797, BRN 0107615; 930-55-2
CAS-Number: C₄H₈N₂O
Molecular Formula: 100.12
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (NMR)
Appearance: Pale yellow to yellow brown liquid
Identity: 1H-NMR

Properties

Solvents: Soluble in chloroform.
Density: 1.085 g/cm3

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Hazard statements: H302+H351
Precautionary statements: P201,P270,P281,P301+P312,P308+P313,P330,P501
GHS Symbol: GHS07+GHS08
Signal word: Warning
Transportation: Not dangerous goods

Description: N-Nitrosopyrrolidine (NPYR) is a nitrosamine and is known to be a potent carcinogen associated with cancer development in animals and humans. NPYR can damage DNA and cause mutations in genes that control cell growth and division. It reacts with DNA in vitro to form genotoxic activity, which may lead to cell death or mutagenesis. NPYR is formed in various industrial processes, including the synthesis of certain chemicals where it is used as an organic solvent, pharmaceutical intermediate, and plasticizer. Functions as an analytical reagent for environmental monitoring. This compound can be used as analytical reference material. NPYR could be used as a tumor initiator, as a reagent for preparing carcinogenic animal diseases moδ NPYR has also neurological effects, inhibiting NMDA receptors.
Smiles: C1CCN(C1)N=O
References: (1) W. Lijinsky & H.W. Taylor, Cancer Res. 36, 1988 (1976) , (2) Y.Y. Fong & W.C. Chan, Food Cosmet. Toxicol. 15, 143 (1977) , (3) S.S. Hecht, et al., Cancer Res. 38, 215 (1978) , (4) J.I. Gray & M.E. Collins, J. Food Prot. 41, 36 (1978) , (5) M. Habs, et al., Int. J. Cancer 26, 47 (1980) , (6) E.J. Hunt & R.C. Shank, BBRC 104, 1343 (1982) , (7) O. Manzoni, et al., Neuron 8, 653 (1992) , (8) S. Krishnan, et al., Chem. Commun. 17, 1713 (2007) , (9) Y. Li & S.S. Hecht, Int. J. Mol. Sci. 23, 4559 (2022) , (10) M. Bignami, et al., Efsa J. 21, e07884 (2023)

N-Nitrosopyrrolidine (NPYR) is a nitrosamine and is known to be a potent carcinogen associated with cancer development in animals and humans. NPYR can damage DNA and cause mutations in genes that control cell growth and division. It reacts with DNA in vitro to form genotoxic activity, which may lead to cell death or mutagenesis. NPYR is formed in various industrial processes, including the synthesis of certain chemicals where it is used as an organic solvent, pharmaceutical intermediate, and plasticizer. Functions as an analytical reagent for environmental monitoring. This compound can be used as analytical reference material. NPYR could be used as a tumor initiator, as a reagent for preparing carcinogenic animal diseases moδ NPYR has also neurological effects, inhibiting NMDA receptors.

SKU: N0378 Category: Building Blocks, Intermediates, Reagents

Additional information

Additional information

Synonyms	NPYR, NSC 18797, BRN 0107615
Purity	≥95% (NMR)
Appearance	Pale yellow to yellow brown liquid
CAS-Number	930-55-2
Molecular Formula	C4H8N2O
Molecular Weight	100.12
Identity	1H-NMR
Solvents	Soluble in chloroform.
Density	1.085 g/cm3
Smiles	C1CCN(C1)N=O
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H302+H351
Precautionary statements	P201,P270,P281,P301+P312,P308+P313,P330,P501
GHS Symbol	GHS07+GHS08
Signal word	Warning
Transportation	Not dangerous goods
References	(1) W. Lijinsky & H.W. Taylor, Cancer Res. 36, 1988 (1976), (2) Y.Y. Fong & W.C. Chan, Food Cosmet. Toxicol. 15, 143 (1977), (3) S.S. Hecht, et al., Cancer Res. 38, 215 (1978), (4) J.I. Gray & M.E. Collins, J. Food Prot. 41, 36 (1978), (5) M. Habs, et al., Int. J. Cancer 26, 47 (1980), (6) E.J. Hunt & R.C. Shank, BBRC 104, 1343 (1982), (7) O. Manzoni, et al., Neuron 8, 653 (1992), (8) S. Krishnan, et al., Chem. Commun. 17, 1713 (2007), (9) Y. Li & S.S. Hecht, Int. J. Mol. Sci. 23, 4559 (2022), (10) M. Bignami, et al., Efsa J. 21, e07884 (2023)
Quantity	1 g, Bulk