Available from stock
Category: Fluorescent Detection
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Neocuproine is a complexing reagents, known for its ability to form stable complexes with metal ions, particularly CU2+ ions. This property makes it valuable in various analytical and research applications, including spectrophotometry and electrochemistry. In the presence of CU2+ ions, neocuproine forms a brightly colored complex that can be used for the quantitative determination of copper in solution. The Neocuproine-CU2+ complex exists in a 2:1 ratio with a maximum absorption at 454 nm. Neocuproine is used in complex with Cu2+ as chromogenic oxidant in the total antioxidant capacity assay (CUPRAC method). In addition to its analytical uses, neocuproine and its derivatives have been employed in the field of coordination chemistry to study and synthesize metal complexes. These complexes often have unique properties and are of interest for their potential applications in catalysis, material science, and other areas of chemical research. This compound is also widely used in some biomedical fields, such as in the study of copper metabolism disorders and neurodegenerative diseases and neocuproine-CU2+ complexes have shown biological properties, such as antitumor activity.
| Synonyms | 2,9-Dimethyl-1,10-phenanthroline, DMPHEN, NSC 4280, VUF 7738 |
|---|---|
| Purity | ≥99% (Assay) |
| Appearance | White to light yellow powder |
| CAS-Number | 484-11-7 |
| Molecular Formula | C14H12N2 · 0.5H2O |
| Molecular Weight | 217.27 |
| Identity | 1H-NMR |
| Solvents | Soluble in methanol (50 mg/ml), ethanol (10 mg/ml) or DMSO (25 mg/ml). |
| Melting Point | 159 – 164 °C |
| Smiles | Cc1ccc2ccc3ccc(C)nc3c2n1 |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Hazard statements | H302 – H315 – H318 – H335 |
| Precautionary statements | P280 – P301 + P312 + P330 – P302 + P352 – P305 + P351 + P338 + P310 |
| GHS Symbol | GHS05+GHS07 |
| Signal word | Danger |
| Transportation | Not dangerous goods |
| References | (1) A. Mohindru, et al., Biochem. Pharmacol. 32, 3627 (1983), (2) H.H. Al-Sa′doni, et al., Br. J. Pharmacol. 121, 1047 (1997), (3) J.G. De Man, et al., Eur. J. Pharmacol. 381, 151 (1999), (4) R. Apak, et al., Free Radic. Res. 39, 949 (2005), (5) A.A. Gouda & A.S. Amin, Arabian J. Chem. 3, 159 (2010), (6) O.V. Patel, et al., Biometals 26, 415 (2013), (7) K.A. Jesse, et al., Inorg. Chem. 58, 9057 (2019) |
| Quantity | 25 g, 100 g, Bulk |
| cdx-Water content (K.F.) | ≤5% |
Nonafluoro-tert-butyl alcohol
