Specifications
- Purity
- ≥96% (HPLC)
- Appearance
- Liquid
- Identity
- 1H-NMR
Properties
- Solvents
- acetonitrile
- Refractive Index
- n20/D 1.352-1.354
- Density
- 0.800-0.850 g/ml at 20 °C
Documentation
- Safety Data Sheet (SDS)
- CDX D0502 MSDS.pdf
Available from stock
Ohira-Bestmann Reagent solution(~10% in acetonitrile)
- SKU
- D0502
Category: Building Blocks, Intermediates, Reagents
- Synonyms
- p-(1-Diazo-2-oxopropyl)-phosphonic acid, dimethyl ester , Ohira-Bestmann phosphonate , α-Azido-α-(dimethyl phosphono)acetone
- 90965-06-3
- CAS-Number
- C5H9N2O4P
- Molecular Formula
- 192.11
- Molecular Weight
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H225, H302 + H332, H319
- Precautionary statements
- P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
- GHS Symbol
- GHS02+GHS07
- Signal word
- Danger
- RIDADR
- UN1648 3
- Transportation
- Excepted Quantities
- Description
- Used in the Seyferth-Gilbert homologation which is a chemical reaction of an aryl ketone or aldehyde with dimethyl- or diazomethyl-phosphonate and potassium tert-butoxide to give substituted alkynes.
- Smiles
- COP(=O)(OC)C(=[N+]=[N-])C(C)=O
- InChi Key
- SQHSJJGGWYIFCD-UHFFFAOYSA-N
- References
- (1) P. Callant et al.: Synthetic Communications 14(2), 155-61(1984) , (2) S. Ohira: Synthetic Communications 19(3-4), 561-4 (1989) , (3) S. Kasteren et al.: Nature 446(7139), 1105-1109 (2007) , (4) G.J. Roth et al.: Synthesis (1), 59-62 (2004)
- InChi
- InChI=1S/C5H9N2O4P/c1-4(8)5(7-6)12(9,10-2)11-3/h1-3H3
Used in the Seyferth-Gilbert homologation which is a chemical reaction of an aryl ketone or aldehyde with dimethyl- or diazomethyl-phosphonate and potassium tert-butoxide to give substituted alkynes.
Additional information
| Synonyms | p-(1-Diazo-2-oxopropyl)-phosphonic acid, dimethyl ester, Ohira-Bestmann phosphonate, α-Azido-α-(dimethyl phosphono)acetone |
|---|---|
| Purity | ≥96% (HPLC) |
| Appearance | Liquid |
| CAS-Number | 90965-06-3 |
| Molecular Formula | C5H9N2O4P |
| Molecular Weight | 192.11 |
| Identity | 1H-NMR |
| Solvents | acetonitrile |
| Refractive Index | n20/D 1.352-1.354 |
| Density | 0.800-0.850 g/ml at 20 °C |
| Smiles | COP(=O)(OC)C(=[N+]=[N-])C(C)=O |
| InChi Key | SQHSJJGGWYIFCD-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H225, H302 + H332, H319 |
| Precautionary statements | P210 – P280 – P301 + P312 – P303 + P361 + P353 – P304 + P340 + P312 – P305 + P351 + P338 |
| GHS Symbol | GHS02+GHS07 |
| Signal word | Danger |
| RIDADR | UN1648 3 |
| Transportation | Excepted Quantities |
| References | (1) P. Callant et al.: Synthetic Communications 14(2), 155-61(1984), (2) S. Ohira: Synthetic Communications 19(3-4), 561-4 (1989), (3) S. Kasteren et al.: Nature 446(7139), 1105-1109 (2007), (4) G.J. Roth et al.: Synthesis (1), 59-62 (2004) |
| InChi | InChI=1S/C5H9N2O4P/c1-4(8)5(7-6)12(9,10-2)11-3/h1-3H3 |
| Quantity | 10 ml, 50 ml, Bulk |
