Specifications
- Purity
- ≥98% (NMR)
- Appearance
- Wthie to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (5 mg/ml)
- Melting Point
- ≥220° C (dec.)
- UV / Vis
- 202 nm
Category: Phytochemicals
Dioscin is a natural steroid saponin originally isolated from plants used in herbal remedies. It has anticancer, anti-inflammatory, immunoregulatory, antioxidant, hyoplipidemic, antiviral, neuroprotective and antifungal activities. It inhibits proliferation, induces autophagy and oxygen-mediated apoptosis in cancer cells. It has been shown to inhibit colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK pathways. It inhibits adipogenesis through the AMPK/MAPK pathway. Dioscin showed protective effect against liver fibrosis by potently inhibiting ITGA5. Promotes proliferation of pancreatic beta cells via Wnt/β-catenin signaling pathways. It has been shown inhibit the nuclear transport of NF-?B and the expression of reactive oxygen species (ROS) and consequently the expression of inflammasome targets such as NLRP3. Potent inhibitor of Skp2, component of the ubiquitin/proteasome degradation pathway.
Synonyms | Collettiside III, Polyphyllin III, CCRIS 4123 |
---|---|
Purity | ≥98% (NMR) |
Appearance | Wthie to off-white powder |
CAS-Number | 19057-60-4 |
Molecular Formula | C45H72O16 |
Molecular Weight | 869.04 |
Identity | 1H-NMR |
Solvents | DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (5 mg/ml) |
Melting Point | ≥220° C (dec.) |
UV / Vis | 202 nm |
Smiles | C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O[C@H](O[C@@H]7CO)[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O)[C@@H]7O[C@@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C |
InChi Key | VNONINPVFQTJOC-ZGXDEBHDSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) J. Cai, et al., Biol. Pharm. Bull. 25, 193 (2002), (2) Z. Wang, et al., Cancer Biol. Ther. 13, 138 (2012), (3) J. cho, et al., Biochim. Biophys. Acta. 1828, 1153 (2013), (4) M.J. Hsieh, et al., Arch. Toxicol. 87, 1927 (2013), (5) L. Lv, et al., Food Chem. Toxicol. 59, 657 (2013), (6) B. Poudel, et al., Int. J. Mol. Med. 34, 1401 (2014), (7) S. Wu, et al., Biochimie 110, 62 (2015), (8) M. Liu, et al., Sci. Rep. 5, 7973 (2015), (9) L. Xu, et al., Food Chem. Toxicol. 107, 318 (2017), (10) F. Yu, et al., Clin. Lab. 64, 785 (2018), (11) X. Tao, et al., Pharmacol. Res. 137, 259 (2018) (Review), (12) Y. Qi, et al., Molecules 24, E1247 (2019), (13) L. Yang, et al., Biomed. Res. Int. 2019, 5763602 (2019) (Review), (14) W. Yin, et al., Small 16, e1905977 (2020), (15) W. Jiang, et al., EBioMedicine 51, 102593 (2020) |
InChi | InChI=1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1 |
Quantity | 25 mg, Bulk |