Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (5 mg/ml), DMF (15 mg/ml), ethanol (10 mg/ml)
- Melting Point
- 222° C (lit.)(dec.)
Category: Phytochemicals
Hederacoside C is a major bioactive constituent isolated from Hedera helix L. It exhibits biological properties such as antibacterial, expectorant, bronchodilator, bronchospasmolytic and anti-inflammatroy effects. It is widely used in the treatment of respiratory disorders involving acute respiratory infections, chronic inflammatory bronchitis and productive coughs. It reduces TNF-α, IL-1β, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity. It reduces scopolamine-induced memory impairment. Hederacoside C markedly suppressed TLR2 and TLR4 expressions by attenuating the MAPKs (p38, ERK, JNK) and NF-?B (p65 and I?Bα) pathways followed by decreasing the phosphorylation of p38, ERK, JNK, p65, and I?Bα.
Synonyms | Hederasaponin C, Kalopanaxsaponin B |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White powder |
CAS-Number | 14216-03-6 |
Molecular Formula | C59H96O26 |
Molecular Weight | 1221.38 |
Identity | 1H-NMR |
Solvents | DMSO (5 mg/ml), DMF (15 mg/ml), ethanol (10 mg/ml) |
Melting Point | 222° C (lit.)(dec.) |
Smiles | ############################################################################################################################################################################################################################################################### |
InChi Key | RYHDIBJJJRNDSX-MCGLQMIESA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H302 |
GHS Symbol | GHS07 |
Signal word | Warning |
RIDADR | UN2811 |
Transportation | Packing Group III |
References | (1) A. Gepdiremen, et al., Phytomedicine 12, 440 (2005), (2) E.H. Joh, et al., Cell Immunol. 279, 103 (2012), (3) E.H. Joh, et al., Phytother. Res. 26, 546 (2012), (4) M. Akhtar, et al., Inflammation (Epub ahead of print) (2019), (5) M. Akhtar, et al., Microb. Pathog. 137, 103767 (2019) |
InChi | InChI=1S/C59H96O26/c1-24-34(63)38(67)42(71)49(78-24)83-46-29(20-60)80-48(45(74)41(46)70)77-22-30-37(66)40(69)44(73)51(81-30)85-53(75)59-17-15-54(3,4)19-27(59)26-9-10-32-55(5)13-12-33(56(6,23-61)31(55)11-14-58(32,8)57(26,7)16-18-59)82-52-47(36(65)28(62)21-76-52)84-50-43(72)39(68)35(64)25(2)79-50/h9,24-25,27-52,60-74H,10-23H2,1-8H3/t24-,25-,27-,28-,29+,30+,31+,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,55-,56-,57+,58+,59-/m0/s1 |
Quantity | 50 mg, Bulk |