Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), ethanol (10 mg/ml)
Category: Phytochemicals
Pseudolaric acid B is a natural diterpenoid isolated from the bark of Pseudolarix kaempferi. It has anti-inflammatory, anticancer, immunosuppressive, antifungal and antifertility properties. Effects relevant to its anticancer properties include, apoptosis and autophagy induction, preventing angiogenesis, microtubule-destabilizing, induction of cell cycle arrest, inhibition of multidrug resistance and inhibition of tumor growth in vivo. It inhibits NF-?B and p38 signaling and has been shown to be a PPARα signaling agonist.
Synonyms | (-)-Pseudolaric acid B, Pseudolarix acid B, PLAB, PAB, NSC 615488 |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 82508-31-4 |
Molecular Formula | C23H28O8 |
Molecular Weight | 432.46 |
Identity | 1H-NMR |
Solvents | DMSO (10 mg/ml), ethanol (10 mg/ml) |
Smiles | O=C(C)O[C@@]12[C@@]3(CC[C@@]2([H])[C@](C)(OC3=O)/C=C/C=C(C)/C(O)=O)CC=C(C(OC)=O)CC1 |
InChi Key | VDGOFNMYZYBUDT-YDRCMHEVSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H301-H361 |
Precautionary statements | P281-P301 + P310 |
GHS Symbol | GHS06+GHS08 |
Signal word | Danger |
RIDADR | UN2811 |
Transportation | Packing Group III |
References | (1) B.N. Zhou, et al., Planta Med. 47, 35 (1983), (2) E. Li, et al., J. Nat. Prod. 58, 57 (1995), (3) M.S. Jardat, et al., Planta Med. 68, 667 (2002), (4) W.F. Tan, et al., Eur. J. Pharmacol. 499, 219 (2004), (5) M.H. Li, et al., Clin. Cancer Res. 10, 8266 (2004), (6) V.K. Wong, et al., Clin. Cancer Res. 11, 6002 (2005), (7) Y.G. Tong, et al., Mol. Pharmacol. 69, 1226 (2006), (8) T. Li, et al., J. Cell Biochem. 108, 87 (2009), (9) G. Ma, et al., J. Cancer Res. Clin. Oncol. 136, 1333 (2010), (10) L. Hou, et al., J. Cancer Res. Clin. Oncol. 138, 885 (2012), (11) N. Wei, et al: Phytother. Res. 27, 980 (2013), (12) J. Tong, et al., Phytother. Res. 27, 885 (2013), (13) Q. Sun & Y. Li, PLoS One 9, e107830 (2014), (14) M.L. Liu, et al., Front. Pharmacol. 8, 394 (2017) (Review) |
InChi | InChI=1S/C23H28O8/c1-14(18(25)26)6-5-10-21(3)17-9-12-22(20(28)31-21)11-7-16(19(27)29-4)8-13-23(17,22)30-15(2)24/h5-7,10,17H,8-9,11-13H2,1-4H3,(H,25,26)/b10-5+,14-6+/t17-,21+,22+,23-/m0/s1 |
Quantity | 1 mg, 10 mg, Bulk |