Available from stock

Aloe-Emodine

SKU: A0658

Category: Phytochemicals

Synonyms: 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone , 3-Hydroxymethylchrysazine , Rhabarberone , Diacerein Impurity B , NSC 38628; 481-72-1
CAS-Number: C₁₅H₁₀O₅
Molecular Formula: 270.24
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Yellow to orange powder
Identity: 1H-NMR

Properties

Solvents: DMSO (2 mg/ml), DMF (5 mg/ml), water (insoluble)
Melting Point: 223-224° C (dec.)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H315-H319-H335
Precautionary statements: P261-P305 + P351 + P338
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Aloe-emodin is a naturally anthraquinone derivative and an active ingredient of Aloe vera leaves and other plants. Aloe-emodin has been shown to exhibit many pharmacological effects, including anticancer, antivirus, anti-inflammatory, antibacterial, antiparasitic, neuroprotective, and hepatoprotective activities. It has potent laxative action by activating CFTR Cl- channels and inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle. It also demonstrates anti-tumor activity, inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species (ROS) and induces apoptosis in glioma models through disruption of the mitochondria membrane potential. Aloe-emodin is reported to have estrogenic activity as a phytoestrogen, has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and neuroprotective effects in vivo.
Smiles: OC1=C2C(C(C(C=C(CO)C=C3O)=C3C2=O)=O)=CC=C1
InChi Key: YDQWDHRMZQUTBA-UHFFFAOYSA-N
References: (1) T. Pecere, et al., Cancer Res. 60, 2800 (2000) , (2) H. Matsuda, et al., Bioorg. Med. Chem. Lett. 11, 1839 (2001) , (3) G. Srinivas, et al., Med. Res. Rev. 27, 591 (2007) (Review) , (4) H. Yang, et al., Acta Pharmacol. Sin. 32, 834 (2011) , (5) K. Liu, et al., Carcinogenesis 33, 1406 (2012) , (6) J. Xu, et al., Br. J. Pharmacol. 165, 197 (2012) , (7) P.H. Huang, et al., Evid. Based Compl. Alternat. Med. 2013, 1 (2013) , (8) S. Ismail, et al., J. Asian Nat. Prod. Res. 15, 1003 (2013) , (9) M.J. Xie, et al., Asian Pac. J. Cancer Prev. 15, 5201 (2014) , (10) L. Tao, et al., Bioorg. Med. Chem. Lett. 24, 5385 (2014) , (11) R. Chen, et al., Am. J. Chin. Med. 42, 275 (2014) (Review) , (12) X. Dong, et al., Phytother. Res. [Epub ahead of print] (2019) (Review)
InChi: InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2

Aloe-emodin is a naturally anthraquinone derivative and an active ingredient of Aloe vera leaves and other plants. Aloe-emodin has been shown to exhibit many pharmacological effects, including anticancer, antivirus, anti-inflammatory, antibacterial, antiparasitic, neuroprotective, and hepatoprotective activities. It has potent laxative action by activating CFTR Cl- channels and inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle. It also demonstrates anti-tumor activity, inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species (ROS) and induces apoptosis in glioma models through disruption of the mitochondria membrane potential. Aloe-emodin is reported to have estrogenic activity as a phytoestrogen, has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and neuroprotective effects in vivo.

SKU: A0658 Category: Phytochemicals

Additional information

Additional information

Synonyms	1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone, 3-Hydroxymethylchrysazine, Rhabarberone, Diacerein Impurity B, NSC 38628
Purity	≥98% (HPLC)
Appearance	Yellow to orange powder
CAS-Number	481-72-1
Molecular Formula	C15H10O5
Molecular Weight	270.24
Identity	1H-NMR
Solvents	DMSO (2 mg/ml), DMF (5 mg/ml), water (insoluble)
Melting Point	223-224° C (dec.)
Smiles	OC1=C2C(C(C(C=C(CO)C=C3O)=C3C2=O)=O)=CC=C1
InChi Key	YDQWDHRMZQUTBA-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305 + P351 + P338
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) T. Pecere, et al., Cancer Res. 60, 2800 (2000), (2) H. Matsuda, et al., Bioorg. Med. Chem. Lett. 11, 1839 (2001), (3) G. Srinivas, et al., Med. Res. Rev. 27, 591 (2007) (Review), (4) H. Yang, et al., Acta Pharmacol. Sin. 32, 834 (2011), (5) K. Liu, et al., Carcinogenesis 33, 1406 (2012), (6) J. Xu, et al., Br. J. Pharmacol. 165, 197 (2012), (7) P.H. Huang, et al., Evid. Based Compl. Alternat. Med. 2013, 1 (2013), (8) S. Ismail, et al., J. Asian Nat. Prod. Res. 15, 1003 (2013), (9) M.J. Xie, et al., Asian Pac. J. Cancer Prev. 15, 5201 (2014), (10) L. Tao, et al., Bioorg. Med. Chem. Lett. 24, 5385 (2014), (11) R. Chen, et al., Am. J. Chin. Med. 42, 275 (2014) (Review), (12) X. Dong, et al., Phytother. Res. [Epub ahead of print] (2019) (Review)
InChi	InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
Quantity	10 mg, 25 mg, Bulk