Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Yellow to orange powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (2 mg/ml), DMF (5 mg/ml), water (insoluble)
- Melting Point
- 223-224° C (dec.)
Category: Phytochemicals
Aloe-emodin is a naturally anthraquinone derivative and an active ingredient of Aloe vera leaves and other plants. Aloe-emodin has been shown to exhibit many pharmacological effects, including anticancer, antivirus, anti-inflammatory, antibacterial, antiparasitic, neuroprotective, and hepatoprotective activities. It has potent laxative action by activating CFTR Cl- channels and inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle. It also demonstrates anti-tumor activity, inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species (ROS) and induces apoptosis in glioma models through disruption of the mitochondria membrane potential. Aloe-emodin is reported to have estrogenic activity as a phytoestrogen, has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and neuroprotective effects in vivo.
Synonyms | 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone, 3-Hydroxymethylchrysazine, Rhabarberone, Diacerein Impurity B, NSC 38628 |
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Purity | ≥98% (HPLC) |
Appearance | Yellow to orange powder |
CAS-Number | 481-72-1 |
Molecular Formula | C15H10O5 |
Molecular Weight | 270.24 |
Identity | 1H-NMR |
Solvents | DMSO (2 mg/ml), DMF (5 mg/ml), water (insoluble) |
Melting Point | 223-224° C (dec.) |
Smiles | OC1=C2C(C(C(C=C(CO)C=C3O)=C3C2=O)=O)=CC=C1 |
InChi Key | YDQWDHRMZQUTBA-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305 + P351 + P338 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) T. Pecere, et al., Cancer Res. 60, 2800 (2000), (2) H. Matsuda, et al., Bioorg. Med. Chem. Lett. 11, 1839 (2001), (3) G. Srinivas, et al., Med. Res. Rev. 27, 591 (2007) (Review), (4) H. Yang, et al., Acta Pharmacol. Sin. 32, 834 (2011), (5) K. Liu, et al., Carcinogenesis 33, 1406 (2012), (6) J. Xu, et al., Br. J. Pharmacol. 165, 197 (2012), (7) P.H. Huang, et al., Evid. Based Compl. Alternat. Med. 2013, 1 (2013), (8) S. Ismail, et al., J. Asian Nat. Prod. Res. 15, 1003 (2013), (9) M.J. Xie, et al., Asian Pac. J. Cancer Prev. 15, 5201 (2014), (10) L. Tao, et al., Bioorg. Med. Chem. Lett. 24, 5385 (2014), (11) R. Chen, et al., Am. J. Chin. Med. 42, 275 (2014) (Review), (12) X. Dong, et al., Phytother. Res. [Epub ahead of print] (2019) (Review) |
InChi | InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2 |
Quantity | 10 mg, 25 mg, Bulk |