Specifications
- Purity
- ≥97% (NMR)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in water (50mg/ml).
- Optical Activity
- +76°- +84°
Category: Antibiotics
Amikacin is a broad-spectrum aminoglycoside antibiotic and a semisynthetic analog of kanamycin. It irreversibly binds to 16S rRNA and the RNA-binding S12 protein of the 30S subunit and 50S subunit of prokaryotic ribosome and inhibits protein synthesis. It works in a concentration-dependent manner, and has better action in an alkaline environment. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains, due to its resistance to inactivating enzymes. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria. Amikacin can be used to treat non-tubercular mycobacterial infections and tuberculosis when first-line drugs fail to control the infection.
Synonyms | Amikacin disulfate, Biodacyn, Selemycin, Amiglyde, BB-K 8, Novamin, Amikin |
---|---|
Purity | ≥97% (NMR) |
Appearance | White to off-white powder |
CAS-Number | 39831-55-5 |
Molecular Formula | C22H43N5O13 . 2H2SO4 |
Molecular Weight | 781.76 |
Identity | 1H-NMR |
Solvents | Soluble in water (50mg/ml). |
Optical Activity | +76°- +84° |
Smiles | OS(O)(=O)=O.OS(O)(=O)=O.O[C@@H]([C@@H]([C@H]1N)O[C@H]([C@@H]([C@H]2O)O)O[C@H](CN)[C@H]2O)[C@H]([C@@H](C1)N([H])C([C@H](CCN)O)=O)O[C@H]([C@@H]([C@H]3N)O)O[C@H](CO)[C@H]3O |
InChi Key | FXKSEJFHKVNEFI-GCZBSULCSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | [1] H. Kawaguchi, et al., J. Antibiot. 25, 695 (1972), [2] P.K. Yu, et al., Antimicrob. Agents Chemother. 4, 133 (1973), [3] D. Zaske & K. Crossley, Minn. Med. 61, 123 (1978) (Review), [4] F.D. Pien & P.W. Ho, Am. J. Hosp. Pharm. 38, 981 (1981) (Review), [5] A.M. Ristuccia & B.A.Cunha, Ther. Drug Monit. 7, 12 (1985) (Review), [6] M.S. Ramirez & M.E. Tolmasky, Molecules 22, 2267 (2017) (Review) |
InChi | InChI=1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21 |
Quantity | 5 g, 25 g, Bulk |