Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20mg/ml), DMF, chloroform
Available from stock
Linezolid
- SKU
- L0031
Category: Antibiotics
- Synonyms
- N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide , PNU-100766 , U-100766
- 165800-03-3
- CAS-Number
- C16H20FN3O4
- Molecular Formula
- 337.35
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- -20°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H372
- Precautionary statements
- P260
- GHS Symbol
- GHS08
- Signal word
- Danger
- Transportation
- Not dangerous goods
- Description
- Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml). Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes and preventing the formation of a functional 70S initiation complex, thus inhibiting bacterial mRNA translation. Linezolid is also a weak, reversible, nonselective inhibitor of monoamine oxidase.
- Smiles
- CC(NC[C@H]1CN(C2=CC=C(N3CCOCC3)C(F)=C2)C(O1)=O)=O
- InChi Key
- TYZROVQLWOKYKF-ZDUSSCGKSA-N
- References
- (1) C.W. Ford, et al., Antimicrob. Agents Chemother. 40, 1508 (1996) , (2) S.J. Brickner, et al., J. Med. Chem. 39, 673 (1996) , (3) R.N. Jones, et al., Antimicrob. Agents Chemother. 40, 720 (1996) , (4) D. Clemett & A. Markham, Drugs 59, 815 (2000) (Review) , (5) H.B. Fung, et al., Clin. Ther. 23, 356 (2001) (Review) , (6) C.W. Ford, et al., Curr. Drug Targets Infect. Disord. 1, 181 (2001) (Review) , (7) D.M. Livermore, J. Antimicrob. Chemother. 51, ii9 (2003) (Review) , (8) S.J. Brickner, et al., J. Med. Chem. 51, 1981 (2008) (Review) , (9) K.L. Leach, et al., Ann. N. Y. Acad. Sci. 1222, 49 (2011) (Review) , (10) S. Ager & K. Gould, Infect. Drug Resist. 5, 87 (2012) , (11) B.A. Diep, et al., Curr. Ther. Res. Clin. Exp. 73, 86 (2012) (Review) , (12) L.A. Pauchard, et al., PLoS One 12, e0187187 (2017)
Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml). Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes and preventing the formation of a functional 70S initiation complex, thus inhibiting bacterial mRNA translation. Linezolid is also a weak, reversible, nonselective inhibitor of monoamine oxidase.
Additional information
| Synonyms | N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, PNU-100766, U-100766 |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 165800-03-3 |
| Molecular Formula | C16H20FN3O4 |
| Molecular Weight | 337.35 |
| Identity | 1H-NMR |
| Solvents | DMSO (20mg/ml), DMF, chloroform |
| Smiles | CC(NC[C@H]1CN(C2=CC=C(N3CCOCC3)C(F)=C2)C(O1)=O)=O |
| InChi Key | TYZROVQLWOKYKF-ZDUSSCGKSA-N |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H372 |
| Precautionary statements | P260 |
| GHS Symbol | GHS08 |
| Signal word | Danger |
| Transportation | Not dangerous goods |
| References | (1) C.W. Ford, et al., Antimicrob. Agents Chemother. 40, 1508 (1996), (2) S.J. Brickner, et al., J. Med. Chem. 39, 673 (1996), (3) R.N. Jones, et al., Antimicrob. Agents Chemother. 40, 720 (1996), (4) D. Clemett & A. Markham, Drugs 59, 815 (2000) (Review), (5) H.B. Fung, et al., Clin. Ther. 23, 356 (2001) (Review), (6) C.W. Ford, et al., Curr. Drug Targets Infect. Disord. 1, 181 (2001) (Review), (7) D.M. Livermore, J. Antimicrob. Chemother. 51, ii9 (2003) (Review), (8) S.J. Brickner, et al., J. Med. Chem. 51, 1981 (2008) (Review), (9) K.L. Leach, et al., Ann. N. Y. Acad. Sci. 1222, 49 (2011) (Review), (10) S. Ager & K. Gould, Infect. Drug Resist. 5, 87 (2012), (11) B.A. Diep, et al., Curr. Ther. Res. Clin. Exp. 73, 86 (2012) (Review), (12) L.A. Pauchard, et al., PLoS One 12, e0187187 (2017) |
| Quantity | 25 mg, Bulk |
