Specifications
- Purity
- ≥95% (HPLC)
- Identity
- 1H-NMR
- Appearance
- Red to orange solid
Properties
- Melting Point
- 251-253 °C
- Solvents
- acetone, methanol, water
Available from stock
Actinomycin D
- SKU
- A0043
Category: Antibiotics
- Synonyms
- 2-Amino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazin e-1,9-dicarboxamide
- 50-76-0
- CAS-Number
- C62H86N12O16
- Molecular Formula
- 1255.42
- Molecular Weight
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Long Term Storage
- -20°C
- Short Term Storage
- +4°C
- Shipping
- AMBIENT
- Transportation
- Packing Group II
- RIDADR
- UN3462 6.1
- Signal word
- Danger
- GHS Symbol
- GHS06
- Precautionary statements
- P264-P301 + P310
- Hazard statements
- H300
- Description
- Biochemical/physiological actions: An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
- InChi
- InChI=1S/C62H85N11O16/c1-28(2)43-59(83)72-23-17-19-38(72)57(81)68(13)26-41(75)70(15)49(30(5)6)61(85)87-34(11)45(55(79)64-43)66-53(77)36-22-21-32(9)51-47(36)63-48-37(25-40(74)33(10)52(48)89-51)54(78)67-46-35(12)88-62(86)50(31(7)8)71(16)42(76)27-69(14)58(82)39-20-18-24-73(39)60(84)44(29(3)4)65-56(46)80/h21-22,25,28-31,34-35,38-39,43-46,49-50H,17-20,23-24,26-27H2,1-16H3,(H,64,79)(H,65,80)(H,66,77)(H,67,78)/t34-,35-,38+,39+,43-,44-,45+,46+,49+,50+/m0/s1
- References
- (1) H. Li et al. Bioorg. Med. Chem. 14(12), 4089 (2006) , (2) C. Liu et al.: Biochem. 35(50), 16346 (1996) , (3) J.A. Neidhart et al.: Cancer Treatment Reports 64(4-5), 553 (1980)
- InChi Key
- ZOWMRHVAQGTFTG-IZRKADTCSA-N
- Smiles
- CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]2CCCN2C1=O
Biochemical/physiological actions: An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Additional information
| Synonyms | 2-Amino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazin e-1,9-dicarboxamide |
|---|---|
| Purity | ≥95% (HPLC) |
| Appearance | Red to orange solid |
| CAS-Number | 50-76-0 |
| Molecular Formula | C62H86N12O16 |
| Molecular Weight | 1255.42 |
| Identity | 1H-NMR |
| Solvents | acetone, methanol, water |
| Melting Point | 251-253 °C |
| Smiles | CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]2CCCN2C1=O |
| InChi Key | ZOWMRHVAQGTFTG-IZRKADTCSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H300 |
| Precautionary statements | P264-P301 + P310 |
| GHS Symbol | GHS06 |
| Signal word | Danger |
| RIDADR | UN3462 6.1 |
| Transportation | Packing Group II |
| References | (1) H. Li et al. Bioorg. Med. Chem. 14(12), 4089 (2006), (2) C. Liu et al.: Biochem. 35(50), 16346 (1996), (3) J.A. Neidhart et al.: Cancer Treatment Reports 64(4-5), 553 (1980) |
| InChi | InChI=1S/C62H85N11O16/c1-28(2)43-59(83)72-23-17-19-38(72)57(81)68(13)26-41(75)70(15)49(30(5)6)61(85)87-34(11)45(55(79)64-43)66-53(77)36-22-21-32(9)51-47(36)63-48-37(25-40(74)33(10)52(48)89-51)54(78)67-46-35(12)88-62(86)50(31(7)8)71(16)42(76)27-69(14)58(82)39-20-18-24-73(39)60(84)44(29(3)4)65-56(46)80/h21-22,25,28-31,34-35,38-39,43-46,49-50H,17-20,23-24,26-27H2,1-16H3,(H,64,79)(H,65,80)(H,66,77)(H,67,78)/t34-,35-,38+,39+,43-,44-,45+,46+,49+,50+/m0/s1 |
| Quantity | 20 mg, Bulk |
