- Synonyms: 2-Amino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-pheno
- Purity: ≥95% (HPLC)
- Appearance: Red to orange solid.
- CAS-Number: 50-76-0
- Molecular Formula: C62H86N12O16
- Molecular Weight: 1255.42
- Identity: 1H-NMR
- Solvents: acetone or methanol
- Melting Point: 251-253 °C
- Smiles: CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN
- InChi: InChI=1S/C62H85N11O16/c1-28(2)43-59(83)72-23-17-19-38(72)57(81)68(13)26-41(75)70(15)49(30(5)6)61(85)87-34(11)45(55(79)64-43)66-53(77)36-22-21-32(9)51-47(36)63-48-37(25-40(74)33(10)52(48)89-51)54(78)67
- InChi Key: ZOWMRHVAQGTFTG-IZRKADTCSA-N
Available from stock
Actinomycin D
SKU: A0043
Category: Antibiotics
- Shipping: AMBIENT
- Short Term Storage: +4°C
- Long Term Storage: -20°C
- Handling Advice: Protect from light and moisture.
- Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
- Description: Biochemical/physiological actions: An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
- References: (1) H. Li et al. Bioorg. Med. Chem. 14(12), 4089 (2006), (2) C. Liu et al.; Biochem. 35(50), 16346 (1996), (3) J.A. Neidhart et al.; Cancer Treatment Reports 64(4-5), 553 (1980)
Biochemical/physiological actions: An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Additional information
| InChi | InChI=1S/C62H85N11O16/c1-28(2)43-59(83)72-23-17-19-38(72)57(81)68(13)26-41(75)70(15)49(30(5)6)61(85)87-34(11)45(55(79)64-43)66-53(77)36-22-21-32(9)51-47(36)63-48-37(25-40(74)33(10)52(48)89-51)54(78)67 |
|---|---|
| Identity | 1H-NMR |
| Availability | 1 |
| CAS-Number | 50-76-0 |
| Melting Point | 251-253 °C |
| Long Term Storage | -20°C |
| Quantity | 20 mg, Bulk |
| Appearance | Red to orange solid. |
| InChi Key | ZOWMRHVAQGTFTG-IZRKADTCSA-N |
| Handling Advice | Protect from light and moisture. |
| Molecular Formula | |
| Short Term Storage | +4°C |
| Purity | |
| Pricetable | |
| References | (1) H. Li et al. Bioorg. Med. Chem. 14(12), 4089 (2006), (2) C. Liu et al.; Biochem. 35(50), 16346 (1996), (3) J.A. Neidhart et al.; Cancer Treatment Reports 64(4-5), 553 (1980) |
| Smiles | CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Molecular Weight | |
| Solvents | acetone or methanol |
| Synonyms | 2-Amino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-pheno |
| Shipping | AMBIENT |
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