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    Actinomycin D

    Available from stock

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      Actinomycin D

      SKU
      A0043

      Category: Antibiotics

      Synonyms
      2-Amino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazin e-1,9-dicarboxamide
      50-76-0
      CAS-Number
      C62H86N12O16
      Molecular Formula
      1255.42
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPLC)
      Identity
      1H-NMR
      Appearance
      Red to orange solid

      Properties

      Melting Point
      251-253 °C
      Solvents
      acetone, methanol, water

      Downloads

      Safety Data Sheet
      CDX A0043 MSDS.pdf
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Long Term Storage
      -20°C
      Short Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Packing Group II
      RIDADR
      UN3462 6.1
      Signal word
      Danger
      GHS Symbol
      GHS06
      Precautionary statements
      P264-P301 + P310
      Hazard statements
      H300
      Description
      Biochemical/physiological actions: An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
      InChi
      InChI=1S/C62H85N11O16/c1-28(2)43-59(83)72-23-17-19-38(72)57(81)68(13)26-41(75)70(15)49(30(5)6)61(85)87-34(11)45(55(79)64-43)66-53(77)36-22-21-32(9)51-47(36)63-48-37(25-40(74)33(10)52(48)89-51)54(78)67-46-35(12)88-62(86)50(31(7)8)71(16)42(76)27-69(14)58(82)39-20-18-24-73(39)60(84)44(29(3)4)65-56(46)80/h21-22,25,28-31,34-35,38-39,43-46,49-50H,17-20,23-24,26-27H2,1-16H3,(H,64,79)(H,65,80)(H,66,77)(H,67,78)/t34-,35-,38+,39+,43-,44-,45+,46+,49+,50+/m0/s1
      References
      (1) H. Li et al. Bioorg. Med. Chem. 14(12), 4089 (2006) , (2) C. Liu et al.: Biochem. 35(50), 16346 (1996) , (3) J.A. Neidhart et al.: Cancer Treatment Reports 64(4-5), 553 (1980)
      InChi Key
      ZOWMRHVAQGTFTG-IZRKADTCSA-N
      Smiles
      CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]2CCCN2C1=O

      Biochemical/physiological actions: An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.

      SKU: A0043 Category: Antibiotics
      • Additional information

      Additional information

      Synonyms

      2-Amino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazin e-1,9-dicarboxamide

      Purity

      ≥95% (HPLC)

      Appearance

      Red to orange solid

      CAS-Number

      50-76-0

      Molecular Formula

      C62H86N12O16

      Molecular Weight

      1255.42

      Identity

      1H-NMR

      Solvents

      acetone, methanol, water

      Melting Point

      251-253 °C

      Smiles

      CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]2CCCN2C1=O

      InChi Key

      ZOWMRHVAQGTFTG-IZRKADTCSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Hazard statements

      H300

      Precautionary statements

      P264-P301 + P310

      GHS Symbol

      GHS06

      Signal word

      Danger

      RIDADR

      UN3462 6.1

      Transportation

      Packing Group II

      References

      (1) H. Li et al. Bioorg. Med. Chem. 14(12), 4089 (2006), (2) C. Liu et al.: Biochem. 35(50), 16346 (1996), (3) J.A. Neidhart et al.: Cancer Treatment Reports 64(4-5), 553 (1980)

      InChi

      InChI=1S/C62H85N11O16/c1-28(2)43-59(83)72-23-17-19-38(72)57(81)68(13)26-41(75)70(15)49(30(5)6)61(85)87-34(11)45(55(79)64-43)66-53(77)36-22-21-32(9)51-47(36)63-48-37(25-40(74)33(10)52(48)89-51)54(78)67-46-35(12)88-62(86)50(31(7)8)71(16)42(76)27-69(14)58(82)39-20-18-24-73(39)60(84)44(29(3)4)65-56(46)80/h21-22,25,28-31,34-35,38-39,43-46,49-50H,17-20,23-24,26-27H2,1-16H3,(H,64,79)(H,65,80)(H,66,77)(H,67,78)/t34-,35-,38+,39+,43-,44-,45+,46+,49+,50+/m0/s1

      Quantity

      20 mg, Bulk

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