Actinomycin D

Available from stock

Actinomycin D

SKU
A0043

Category:

Synonyms
2-Amino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazin e-1,9-dicarboxamide
50-76-0
CAS-Number
C62H86N12O16
Molecular Formula
1255.42
Molecular Weight

Specifications

Purity
≥95% (HPLC)
Identity
1H-NMR
Appearance
Red to orange solid

Properties

Melting Point
251-253 °C
Solvents
acetone, methanol, water

Downloads

Safety Data Sheet
CDX A0043 MSDS.pdf
Handling Advice
Protect from light and moisture.
Use / Stability
Stable for at least 2 years after receipt when stored at -20°C.
Long Term Storage
-20°C
Short Term Storage
+4°C
Shipping
AMBIENT
Transportation
Packing Group II
RIDADR
UN3462 6.1
Signal word
Danger
GHS Symbol
GHS06
Precautionary statements
P264-P301 + P310
Hazard statements
H300
Description
Biochemical/physiological actions: An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
InChi
InChI=1S/C62H85N11O16/c1-28(2)43-59(83)72-23-17-19-38(72)57(81)68(13)26-41(75)70(15)49(30(5)6)61(85)87-34(11)45(55(79)64-43)66-53(77)36-22-21-32(9)51-47(36)63-48-37(25-40(74)33(10)52(48)89-51)54(78)67-46-35(12)88-62(86)50(31(7)8)71(16)42(76)27-69(14)58(82)39-20-18-24-73(39)60(84)44(29(3)4)65-56(46)80/h21-22,25,28-31,34-35,38-39,43-46,49-50H,17-20,23-24,26-27H2,1-16H3,(H,64,79)(H,65,80)(H,66,77)(H,67,78)/t34-,35-,38+,39+,43-,44-,45+,46+,49+,50+/m0/s1
References
(1) H. Li et al. Bioorg. Med. Chem. 14(12), 4089 (2006) , (2) C. Liu et al.: Biochem. 35(50), 16346 (1996) , (3) J.A. Neidhart et al.: Cancer Treatment Reports 64(4-5), 553 (1980)
InChi Key
ZOWMRHVAQGTFTG-IZRKADTCSA-N
Smiles
CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]2CCCN2C1=O

Biochemical/physiological actions: An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.

SKU: A0043 Category:

Additional information

Synonyms

2-Amino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazin e-1,9-dicarboxamide
Purity

≥95% (HPLC)
Appearance

Red to orange solid
CAS-Number

50-76-0
Molecular Formula

C62H86N12O16
Molecular Weight

1255.42
Identity

1H-NMR
Solvents

acetone, methanol, water
Melting Point

251-253 °C
Smiles

CC(C)[C@@H]1NC(=O)[C@H](NC(=O)C2=CC=C(C)C3=C2N=C2C(O3)=C(C)C(=O)C=C2C(=O)N[C@@H]2[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]3CCCN3C(=O)[C@@H](NC2=O)C(C)C)[C@H](C)OC(=O)[C@@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@H]2CCCN2C1=O
InChi Key

ZOWMRHVAQGTFTG-IZRKADTCSA-N
Shipping

AMBIENT
Short Term Storage

+4°C
Long Term Storage

-20°C
Handling Advice

Protect from light and moisture.
Use / Stability

Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements

H300
Precautionary statements

P264-P301 + P310
GHS Symbol

GHS06
Signal word

Danger
RIDADR

UN3462 6.1
Transportation

Packing Group II
References

(1) H. Li et al. Bioorg. Med. Chem. 14(12), 4089 (2006), (2) C. Liu et al.: Biochem. 35(50), 16346 (1996), (3) J.A. Neidhart et al.: Cancer Treatment Reports 64(4-5), 553 (1980)
InChi

InChI=1S/C62H85N11O16/c1-28(2)43-59(83)72-23-17-19-38(72)57(81)68(13)26-41(75)70(15)49(30(5)6)61(85)87-34(11)45(55(79)64-43)66-53(77)36-22-21-32(9)51-47(36)63-48-37(25-40(74)33(10)52(48)89-51)54(78)67-46-35(12)88-62(86)50(31(7)8)71(16)42(76)27-69(14)58(82)39-20-18-24-73(39)60(84)44(29(3)4)65-56(46)80/h21-22,25,28-31,34-35,38-39,43-46,49-50H,17-20,23-24,26-27H2,1-16H3,(H,64,79)(H,65,80)(H,66,77)(H,67,78)/t34-,35-,38+,39+,43-,44-,45+,46+,49+,50+/m0/s1
Quantity

20 mg, Bulk

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