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    Amikacin hydrate

    Available from stock

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      Amikacin hydrate

      SKU
      A0287

      Category: Antibiotics

      Synonyms
      N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A , Amicacin , Amikacillin , Amukin , Antibiotic BB-K 8 , BAY 41-6551 , BAY 416651
      37517-28-5 (anhydr
      CAS-Number
      C22H43N5O13 · xH2O
      Molecular Formula
      585.60 (anhydrous basis)
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥97% (NMR)
      Appearance
      White crystalline powder
      Identity
      IR

      Properties

      Solvents
      water (10 mg/ml), methanol
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      +4°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Transportation
      Not dangerous goods
      Description
      Broad-spectrum semisynthetic aminoglycoside antibiotic derived from kanamycin A, which is effective against Gram-negative and Gram-positive bacteria. Aminoglycoside antibiotics bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation, consequently inhibiting bacterial protein synthesis.
      Smiles
      O[C@@H]1[C@@H](CN)O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@@H]3[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O3)[C@H](NC([C@H](CCN)O)=O)C[C@@H]2N)[C@H](O)[C@H]1O
      InChi Key
      LKCWBDHBTVXHDL-RMDFUYIESA-N
      References
      (1) H. Kawaguchi, et al., J. Antibiot. 25, 695 (1972) , (2) K.E. Price, et al., Antimicrob. Agents Chemother. 5, 143 (1974) , (3) N.S. Brewer, Mayo Clin. Proc. 52, 675 (1977) , (4) R.N. Jones, et al., Antimicrob. Agents Chemother. 22, 985 (1982) , (5) A.M. Ristuccia & B.A. Cunha, Ther. Drug Monit. 7, 12 (1985) , (6) B.D. Davis, Microbiol. Rev. 51, 341 (1987) , (7) B.A. Cunha, Med. Clin. North Am. 90, 1089 (2006) , (8) M.S. Ramirez & M.E. Tolmasky, Molecules 22, E2267 (2017)
      InChi
      InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1

      Broad-spectrum semisynthetic aminoglycoside antibiotic derived from kanamycin A, which is effective against Gram-negative and Gram-positive bacteria. Aminoglycoside antibiotics bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation, consequently inhibiting bacterial protein synthesis.

      SKU: A0287 Category: Antibiotics
      • Additional information

      Additional information

      Synonyms

      N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A, Amicacin, Amikacillin, Amukin, Antibiotic BB-K 8, BAY 41-6551, BAY 416651

      Purity

      ≥97% (NMR)

      Appearance

      White crystalline powder

      CAS-Number

      37517-28-5 (anhydr

      Molecular Formula

      C22H43N5O13 · xH2O

      Molecular Weight

      585.60 (anhydrous basis)

      Identity

      IR

      Solvents

      water (10 mg/ml), methanol

      Smiles

      O[C@@H]1[C@@H](CN)O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@@H]3[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O3)[C@H](NC([C@H](CCN)O)=O)C[C@@H]2N)[C@H](O)[C@H]1O

      InChi Key

      LKCWBDHBTVXHDL-RMDFUYIESA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Transportation

      Not dangerous goods

      References

      (1) H. Kawaguchi, et al., J. Antibiot. 25, 695 (1972), (2) K.E. Price, et al., Antimicrob. Agents Chemother. 5, 143 (1974), (3) N.S. Brewer, Mayo Clin. Proc. 52, 675 (1977), (4) R.N. Jones, et al., Antimicrob. Agents Chemother. 22, 985 (1982), (5) A.M. Ristuccia & B.A. Cunha, Ther. Drug Monit. 7, 12 (1985), (6) B.D. Davis, Microbiol. Rev. 51, 341 (1987), (7) B.A. Cunha, Med. Clin. North Am. 90, 1089 (2006), (8) M.S. Ramirez & M.E. Tolmasky, Molecules 22, E2267 (2017)

      InChi

      InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1

      Quantity

      5 g, Bulk

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