Specifications
- Purity
- ≥97% (NMR)
- Appearance
- White crystalline powder
- Identity
- IR
Properties
- Solvents
- water (10 mg/ml), methanol
Category: Antibiotics
Broad-spectrum semisynthetic aminoglycoside antibiotic derived from kanamycin A, which is effective against Gram-negative and Gram-positive bacteria. Aminoglycoside antibiotics bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation, consequently inhibiting bacterial protein synthesis.
Synonyms | N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A, Amicacin, Amikacillin, Amukin, Antibiotic BB-K 8, BAY 41-6551, BAY 416651 |
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Purity | ≥97% (NMR) |
Appearance | White crystalline powder |
CAS-Number | 37517-28-5 (anhydr |
Molecular Formula | C22H43N5O13 · xH2O |
Molecular Weight | 585.60 (anhydrous basis) |
Identity | IR |
Solvents | water (10 mg/ml), methanol |
Smiles | O[C@@H]1[C@@H](CN)O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@@H]3[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O3)[C@H](NC([C@H](CCN)O)=O)C[C@@H]2N)[C@H](O)[C@H]1O |
InChi Key | LKCWBDHBTVXHDL-RMDFUYIESA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) H. Kawaguchi, et al., J. Antibiot. 25, 695 (1972), (2) K.E. Price, et al., Antimicrob. Agents Chemother. 5, 143 (1974), (3) N.S. Brewer, Mayo Clin. Proc. 52, 675 (1977), (4) R.N. Jones, et al., Antimicrob. Agents Chemother. 22, 985 (1982), (5) A.M. Ristuccia & B.A. Cunha, Ther. Drug Monit. 7, 12 (1985), (6) B.D. Davis, Microbiol. Rev. 51, 341 (1987), (7) B.A. Cunha, Med. Clin. North Am. 90, 1089 (2006), (8) M.S. Ramirez & M.E. Tolmasky, Molecules 22, E2267 (2017) |
InChi | InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1 |
Quantity | 5 g, Bulk |