Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), ethanol (1 mg/ml), water (25 mg/ml)
- Melting Point
- 195 °C
Available from stock
Arbutin
- SKU
- A0402
Category: Carbohydrates
- Synonyms
- β-Arbutin , NSC 4036 , 4-Hydroxyphenyl-β-D-glucopyranoside , p-Arbutin , Hydroquinone β-D-glucopyranoside
- 497-76-7
- CAS-Number
- C12H16O7
- Molecular Formula
- 272.25
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Arbutin is a glycosylated hydroquinone used in traditional Chinese medicine (TCM) that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, anti-tumor and anti-inflammatory properties. Arbutin is a competitive inhibitor of tyrosinase in melanocytes (suppressing production of melanin) and therefore used as a skin-lightening agent and in the treatment of hyperpigmentation disorders.
- Smiles
- O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC=C(O)C=C2)[C@@H]1O
- InChi Key
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N
- References
- (1) K. Maeda & M. Fukuda, JPET 276, 765 (1996) , (2) J. Takebayashi, et al., Free Radic. Res. 44, 473 (2010) , (3) D.-H. Seo, et al., Appl. Microbiol. Biotechnol. 95, 1417 (2012) , (4) A. Garcia-Jimenez, et al., PLoS One 12, e0177330 (2017) , (5) J. Ye, et al., Pulm. Pharmacol. Ther. 54, 53 (2019)
- InChi
- InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
Arbutin is a glycosylated hydroquinone used in traditional Chinese medicine (TCM) that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, anti-tumor and anti-inflammatory properties. Arbutin is a competitive inhibitor of tyrosinase in melanocytes (suppressing production of melanin) and therefore used as a skin-lightening agent and in the treatment of hyperpigmentation disorders.
Additional information
| Synonyms | β-Arbutin, NSC 4036, 4-Hydroxyphenyl-β-D-glucopyranoside, p-Arbutin, Hydroquinone β-D-glucopyranoside |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | Light yellow powder |
| CAS-Number | 497-76-7 |
| Molecular Formula | C12H16O7 |
| Molecular Weight | 272.25 |
| Identity | 1H-NMR |
| Solvents | DMSO (10 mg/ml), ethanol (1 mg/ml), water (25 mg/ml) |
| Melting Point | 195 °C |
| Smiles | O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC=C(O)C=C2)[C@@H]1O |
| InChi Key | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) K. Maeda & M. Fukuda, JPET 276, 765 (1996), (2) J. Takebayashi, et al., Free Radic. Res. 44, 473 (2010), (3) D.-H. Seo, et al., Appl. Microbiol. Biotechnol. 95, 1417 (2012), (4) A. Garcia-Jimenez, et al., PLoS One 12, e0177330 (2017), (5) J. Ye, et al., Pulm. Pharmacol. Ther. 54, 53 (2019) |
| InChi | InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1 |
| Quantity | 10 g, 25 g, 50 g, Bulk |
