Specifications
- Purity
- ≥95% (NMR)
- Appearance
- White creamy powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, ethanol, methanol (slighty)
- Melting Point
- 230 - 233 °C
Available from stock
Asiaticoside
- SKU
- A0575
Category: Phytochemicals
- Synonyms
- Blastostimulina , Centelase , Emdecassol , Madecassol , Marticassol , FK1080 , BRN 0078195 , NSC 166062
- 16830-15-2
- CAS-Number
- C48H78O19
- Molecular Formula
- 959.133
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Transportation
- Not dangerous goods
- Description
- Asiaticoside is the main saponin constituent of C. asiatica, a plant long used in the Ayurvedic system of medicine to treat dermatitis, diabetes, cough, cataract, hypertension, as well as for wound healing and improving memory. It is a human collagen I synthesis inducer with anti-wrinkle activity. It shows wound healing activity, enhancing normal human skin cell migration, attachment and growth. Asiaticoside is an anti-inflammatory compound that inibits MAPKs, NF-?B, COX-2 and iNOS expression, and production of TNF-α and IL-6. Also shown to induce apoptosis and autophagy in cancer cells. Described to have also antibacterial, antioxidant, anxiolytic, antidepressant-like, hepatoprotective, neuroprotective and antileishmanial activity.
- Smiles
- CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)CO)O)O)C)C)C2C1C)C)C(=O)OC6C(C(C(C(O6)COC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)O)O)O)O
- InChi Key
- WYQVAPGDARQUBT-HJCNVAKJSA-N
- References
- "(1) A. Shukla, et al., J. Ethnopharmacol. 65, 1 (1999) , (2) J.H. Sampson, et al., Phytomedicine 8, 230 (2001) , (3) J.S. Guo, et al., Planta Med. 70, 1150 (2004) , (4) J.S. Ryu, et al., Skin Res. Technol. 11, 157 (2005) , (5) S.W. Chen, et al., Pharmacol. Biochem. Behav. 85, 339 (2006) , (6) X. Liang, et al., Pharmacol. Biochem. Behav. 89, 444 (2008) , (7) C.L. Xu, et al., Pharmacol. Biochem. Behav. 100, 413 (2012) , (8) S.K. Bhaumik, et al., J. Antimicrob. Chemother. 67, 910 (2012) , (9) J.H. Lee, et al., Phytomedicine 19, 1223 (2012) , (10) J. Wan, et al., Phytother. Res. 27, 1136 (2013) , (11) F.Y. Qi, et al., Neural. Regen. Res. 9, 1275 (2014) , (12) Y. Luo, et al., Mol. Med. Rep. 12, 8294 (2015) , (13) Q. Hou, et al., Exp. Ther. Med. 12, 1269 (2016) , (14) X. Wang, et al., Mol. Med. Rep. 17, 2893 (2018) , (15) L. Jing, et al., Cytotechnology 70, 855 (2018) , (16) L. Yingchun, et al., Med. Sci. Monit. 25, 1355 (2019)
Asiaticoside is the main saponin constituent of C. asiatica, a plant long used in the Ayurvedic system of medicine to treat dermatitis, diabetes, cough, cataract, hypertension, as well as for wound healing and improving memory. It is a human collagen I synthesis inducer with anti-wrinkle activity. It shows wound healing activity, enhancing normal human skin cell migration, attachment and growth. Asiaticoside is an anti-inflammatory compound that inibits MAPKs, NF-?B, COX-2 and iNOS expression, and production of TNF-α and IL-6. Also shown to induce apoptosis and autophagy in cancer cells. Described to have also antibacterial, antioxidant, anxiolytic, antidepressant-like, hepatoprotective, neuroprotective and antileishmanial activity.
Additional information
| Synonyms | Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062 |
|---|---|
| Purity | ≥95% (NMR) |
| Appearance | White creamy powder |
| CAS-Number | 16830-15-2 |
| Molecular Formula | C48H78O19 |
| Molecular Weight | 959.133 |
| Identity | 1H-NMR |
| Solvents | DMSO, ethanol, methanol (slighty) |
| Melting Point | 230 – 233 °C |
| Smiles | CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)CO)O)O)C)C)C2C1C)C)C(=O)OC6C(C(C(C(O6)COC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)O)O)O)O |
| InChi Key | WYQVAPGDARQUBT-HJCNVAKJSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Transportation | Not dangerous goods |
| References | "(1) A. Shukla, et al., J. Ethnopharmacol. 65, 1 (1999), (2) J.H. Sampson, et al., Phytomedicine 8, 230 (2001), (3) J.S. Guo, et al., Planta Med. 70, 1150 (2004), (4) J.S. Ryu, et al., Skin Res. Technol. 11, 157 (2005), (5) S.W. Chen, et al., Pharmacol. Biochem. Behav. 85, 339 (2006), (6) X. Liang, et al., Pharmacol. Biochem. Behav. 89, 444 (2008), (7) C.L. Xu, et al., Pharmacol. Biochem. Behav. 100, 413 (2012), (8) S.K. Bhaumik, et al., J. Antimicrob. Chemother. 67, 910 (2012), (9) J.H. Lee, et al., Phytomedicine 19, 1223 (2012), (10) J. Wan, et al., Phytother. Res. 27, 1136 (2013), (11) F.Y. Qi, et al., Neural. Regen. Res. 9, 1275 (2014), (12) Y. Luo, et al., Mol. Med. Rep. 12, 8294 (2015), (13) Q. Hou, et al., Exp. Ther. Med. 12, 1269 (2016), (14) X. Wang, et al., Mol. Med. Rep. 17, 2893 (2018), (15) L. Jing, et al., Cytotechnology 70, 855 (2018), (16) L. Yingchun, et al., Med. Sci. Monit. 25, 1355 (2019) |
| Quantity | 25 mg, 100 mg, Bulk |
