Available from stock

Astragaloside IV

SKU: A0577

Category: Phytochemicals

Synonyms: AS-IV , AST-IV , Astrasieversianin XIV , Cyclosieversioside F , Cyclosiversioside F , Astramembrannin I , Astragaloside A; 84687-43-4
CAS-Number: C₄₁H₆₈O₁₄
Molecular Formula: 784.98
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: DMSO (30 mg/ml), DMF (20 mg/ml)
Melting Point: 295-296 °C (lit.)

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Astragaloside IV (AS-IV) is a bioactive saponin and constituent of the traditional chinese medicine plant Astragali radix. AS-IV has multiple pharmacologic effects, including anti-inflammatory, antioxidative, anti-asthma, antidiabetes, anticancer, immunoregulation, neuroprotective and cardioprotective properties via numerous signaling pathways. This includes inhibition of NF-kappaB, inducing hypoxia-inducible factor-1α accumulation via PI3K/Akt pathway, reducing Aβ production in Alzheimer's disease through inhibition of BACE1, working as a natural PPARγ agonist, improving lipid metabolism in obese mice, enhancing chemosensitivity through B7-H3 inhibition, and suppressing glucose-induced NLRP3 inflammasome activation.
Smiles: O[C@H]1C[C@@]2(C)[C@]3([H])C[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@]5([H])C(C)(C)[C@@H](O[C@H]6OC[C@@H](O)[C@H](O)[C@H]6O)CC[C@]57[C@]3(C7)CC[C@]2(C)[C@H]1[C@]8(C)O[C@H](C(C)(O)C)CC8
InChi Key: QMNWISYXSJWHRY-RXMVGYINSA-N
References: (1) Y.P. Wang, et al., Acta Pharmacol. Sin. 23, 263 (2002) , (2) W.J. Zhang, et al., Thromb. Haemost. 90, 904 (2003) , (3) M.E. Xu, et al., Acta Pharmacol. Sin. 27, 229 (2006) , (4) W.S. Chan, et al., Neurochem. Int. 55, 414 (2009) , (5) L. Zhang, et al., J. Pharmacol. Exp. Ther. 338, 485 (2011) , (6) X. Chen, et al., J. Ethnopharmacol. 139, 721 (2012) , (7) D. Gui, et al., PLoS One 7, e39824 (2012) , (8) S. Ren, et al., J. Tradit. Chin. Med. 33, 413 (2013) (Review) , (9) H. Wu, et al., Sci. Rep. 6, 30190 (2016) , (10) C.S. He, et al., Cell Physiol. Biochem. 40, 1221 (2016) , (11) X. Wang, et al., Mol. Neurobiol. 54, 2939 (2017) , (12) L. Li, et al., Fundam. Clin. Pharmacol. 31, 17 (2017) (Review) , (13) L. Xia, et al., Exp. Ther. Med. 14, 5569 (2017) , (14) P. Sun, et al., Front. Biosci. 24, 597 (2019) , (15) B. Leng, et al., Mediators Inflamm. 2019, 1082497 (2019) , (16) Z. Zhang, et al., Mol. Med. Rep. 20, 4612 (2019)
InChi: InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33+,34+,37+,38-,39+,40-,41+/m0/s1

Astragaloside IV (AS-IV) is a bioactive saponin and constituent of the traditional chinese medicine plant Astragali radix. AS-IV has multiple pharmacologic effects, including anti-inflammatory, antioxidative, anti-asthma, antidiabetes, anticancer, immunoregulation, neuroprotective and cardioprotective properties via numerous signaling pathways. This includes inhibition of NF-kappaB, inducing hypoxia-inducible factor-1α accumulation via PI3K/Akt pathway, reducing Aβ production in Alzheimer’s disease through inhibition of BACE1, working as a natural PPARγ agonist, improving lipid metabolism in obese mice, enhancing chemosensitivity through B7-H3 inhibition, and suppressing glucose-induced NLRP3 inflammasome activation.

SKU: A0577 Category: Phytochemicals

Additional information

Additional information

Synonyms	AS-IV, AST-IV, Astrasieversianin XIV, Cyclosieversioside F, Cyclosiversioside F, Astramembrannin I, Astragaloside A
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	84687-43-4
Molecular Formula	C41H68O14
Molecular Weight	784.98
Identity	1H-NMR
Solvents	DMSO (30 mg/ml), DMF (20 mg/ml)
Melting Point	295-296 °C (lit.)
Smiles	O[C@H]1C[C@@]2(C)[C@]3([H])C[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@]5([H])C(C)(C)[C@@H](O[C@H]6OC[C@@H](O)[C@H](O)[C@H]6O)CC[C@]57[C@]3(C7)CC[C@]2(C)[C@H]1[C@]8(C)O[C@H](C(C)(O)C)CC8
InChi Key	QMNWISYXSJWHRY-RXMVGYINSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) Y.P. Wang, et al., Acta Pharmacol. Sin. 23, 263 (2002), (2) W.J. Zhang, et al., Thromb. Haemost. 90, 904 (2003), (3) M.E. Xu, et al., Acta Pharmacol. Sin. 27, 229 (2006), (4) W.S. Chan, et al., Neurochem. Int. 55, 414 (2009), (5) L. Zhang, et al., J. Pharmacol. Exp. Ther. 338, 485 (2011), (6) X. Chen, et al., J. Ethnopharmacol. 139, 721 (2012), (7) D. Gui, et al., PLoS One 7, e39824 (2012), (8) S. Ren, et al., J. Tradit. Chin. Med. 33, 413 (2013) (Review), (9) H. Wu, et al., Sci. Rep. 6, 30190 (2016), (10) C.S. He, et al., Cell Physiol. Biochem. 40, 1221 (2016), (11) X. Wang, et al., Mol. Neurobiol. 54, 2939 (2017), (12) L. Li, et al., Fundam. Clin. Pharmacol. 31, 17 (2017) (Review), (13) L. Xia, et al., Exp. Ther. Med. 14, 5569 (2017), (14) P. Sun, et al., Front. Biosci. 24, 597 (2019), (15) B. Leng, et al., Mediators Inflamm. 2019, 1082497 (2019), (16) Z. Zhang, et al., Mol. Med. Rep. 20, 4612 (2019)
InChi	InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33+,34+,37+,38-,39+,40-,41+/m0/s1
Quantity	50 mg, 100 mg, Bulk