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beta-Nicotinamide adenine dinucleotide hydrate

SKU: N0222

Category: Vitamins

Synonyms: beta-DPN , beta-NAD , Coenzyme 1 , Cozymase , DPN , Diphosphopyridine nucleotide , NAD , Nadide , NSC 20272; 53-84-9
CAS-Number: C₂₁H₂₇N₇O₁₄P₂ · xH₂O
Molecular Formula: 663.43 (anhydrous basis)
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to yellow powder
Identity: 1H-NMR

Properties

Solvents: water

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: NAD+, known more formally as nicotinamide adenine dinucleotide, is a signaling molecule as well as a cofactor or substrate for many enzymes. It acts as an oxidizing agent, accepting electrons from other molecules while being converted to its reduced form, NADH. NAD+ is also essential for the activity of several enzymes, including poly(ADP)-ribose polymerases and cADP-ribose synthases. For example, it is used by some sirtuins to mediate protein deacetylation, producing O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein. NAD+ is an important player and factor to research metabolic pathways and pathologies.
Smiles: O[C@H]1C(N2C=NC3=C2N=CN=C3N)O[C@H](COP(O)(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)=O)[C@H]1O
InChi Key: BAWFJGJZGIEFAR-OMYDKTABSA-N
References: (1) B. Schwer & E. Verdin, Cell Metabolism 7, 104 (2008) (Review) , (2) R.H. Houtkooper, et al., Endocr. Rev. 31, 194 (2010) (Review) , (3) Y.S. Elhassan, et al., J. Endocr. Soc. 1, 816 (2017) (Review)
InChi: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20+,21?/m1/s1

NAD+, known more formally as nicotinamide adenine dinucleotide, is a signaling molecule as well as a cofactor or substrate for many enzymes. It acts as an oxidizing agent, accepting electrons from other molecules while being converted to its reduced form, NADH. NAD+ is also essential for the activity of several enzymes, including poly(ADP)-ribose polymerases and cADP-ribose synthases. For example, it is used by some sirtuins to mediate protein deacetylation, producing O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein. NAD+ is an important player and factor to research metabolic pathways and pathologies.

SKU: N0222 Category: Vitamins

Additional information

Additional information

Synonyms	beta-DPN, beta-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucleotide, NAD, Nadide, NSC 20272
Purity	≥98% (HPLC)
Appearance	White to yellow powder
CAS-Number	53-84-9
Molecular Formula	C21H27N7O14P2 · xH2O
Molecular Weight	663.43 (anhydrous basis)
Identity	1H-NMR
Solvents	water
Smiles	O[C@H]1C(N2C=NC3=C2N=CN=C3N)O[C@H](COP(O)(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)=O)[C@H]1O
InChi Key	BAWFJGJZGIEFAR-OMYDKTABSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) B. Schwer & E. Verdin, Cell Metabolism 7, 104 (2008) (Review), (2) R.H. Houtkooper, et al., Endocr. Rev. 31, 194 (2010) (Review), (3) Y.S. Elhassan, et al., J. Endocr. Soc. 1, 816 (2017) (Review)
InChi	InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20+,21?/m1/s1
Quantity	1 g, 5 g, 10 g, Bulk