Available from stock

Calycosin

SKU: C0642

Category: Phytochemicals

Synonyms: 3',7-Dihydroxy-4'-methoxy-isoflavone , 3'-Hydroxyformononetin; 20575-57-9
CAS-Number: C₁₆H₁₂O₅
Molecular Formula: 284.26
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to light yellow powder
Identity: 1H-NMR

Properties

Solvents: DMSO (20 mg/ml), DMF (20 mg/ml), methanol (1 mg/ml)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H301
Precautionary statements: P301 + P310
GHS Symbol: GHS06
Signal word: Danger
RIDADR: UN3462
Transportation: Packing Group III

Description: Calycosin is an isoflavone and phytoestrogen with diverse biological properties, including anti-cancer, anti-inflammatory, antioxidant, neuroprotective, antiplasmodial and antiprotozoal activities. It is an estrogen receptor (ER) partial agonist that inhibits 17β-estradiol binding to ERα and ER, promotion angiogenesis. It has been shown to have calcium blocking activities. Suppressed breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. Shown to induce apoptosis in several cancer types and having antimetastatic and anti-tumor activities.
Smiles: O=C1C=C(C2=CC=C(OC)C(O)=C2)OC3=CC(O)=CC=C31
InChi Key: QAGGICSUEVNSGH-UHFFFAOYSA-N
References: (1) C. Kraft, et al., J. Ethnopharmacol. 73, 131 (2000) , (2) D.-H. Yu, et al., Biomed. Environ. Sci. 18, 297 (2005) , (3) X.L. Wu, et al., Acta Pharmacol. Sin. 27, 1007 (2006) , (4) M.M. Salem & K.A. Werbovetz, J. Nat. Prod. 69, 43 (2006) , (5) J.Y. Tang, et al., PLoS One 5, e11822 (2010) , (6) C. Guo, et al., J. Ethnopharmacol. 144, 768 (2012) , (7) J. Chen, et al., PLoS One 9, e91245 (2014) , (8) R. Qiu, et al., Exp. Mol. Pathol. 97, 17 (2014) , (9) X. Zhao, et al., Gene 591, 123 (2016) , (10) L. Song, et al., Neural. Regen. Res. 12, 1870 (2017) , (11) L. Dong, et al., Gene 675, 94 (2018) , (12) R. Qiu, et al., Biofactors 45, 975 (2019) , (13) C. Huang, et al., Med. Sci. Monit. 25, 5589 (2019)
InChi: InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)19)15-8-12(18)11-4-3-10(17)7-16(11)21-15/h2-8,17,19H,1H3

Calycosin is an isoflavone and phytoestrogen with diverse biological properties, including anti-cancer, anti-inflammatory, antioxidant, neuroprotective, antiplasmodial and antiprotozoal activities. It is an estrogen receptor (ER) partial agonist that inhibits 17β-estradiol binding to ERα and ER, promotion angiogenesis. It has been shown to have calcium blocking activities. Suppressed breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. Shown to induce apoptosis in several cancer types and having antimetastatic and anti-tumor activities.

SKU: C0642 Category: Phytochemicals

Additional information

Additional information

Synonyms	3',7-Dihydroxy-4'-methoxy-isoflavone, 3'-Hydroxyformononetin
Purity	≥98% (HPLC)
Appearance	White to light yellow powder
CAS-Number	20575-57-9
Molecular Formula	C16H12O5
Molecular Weight	284.26
Identity	1H-NMR
Solvents	DMSO (20 mg/ml), DMF (20 mg/ml), methanol (1 mg/ml)
Smiles	O=C1C=C(C2=CC=C(OC)C(O)=C2)OC3=CC(O)=CC=C31
InChi Key	QAGGICSUEVNSGH-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H301
Precautionary statements	P301 + P310
GHS Symbol	GHS06
Signal word	Danger
RIDADR	UN3462
Transportation	Packing Group III
References	(1) C. Kraft, et al., J. Ethnopharmacol. 73, 131 (2000), (2) D.-H. Yu, et al., Biomed. Environ. Sci. 18, 297 (2005), (3) X.L. Wu, et al., Acta Pharmacol. Sin. 27, 1007 (2006), (4) M.M. Salem & K.A. Werbovetz, J. Nat. Prod. 69, 43 (2006), (5) J.Y. Tang, et al., PLoS One 5, e11822 (2010), (6) C. Guo, et al., J. Ethnopharmacol. 144, 768 (2012), (7) J. Chen, et al., PLoS One 9, e91245 (2014), (8) R. Qiu, et al., Exp. Mol. Pathol. 97, 17 (2014), (9) X. Zhao, et al., Gene 591, 123 (2016), (10) L. Song, et al., Neural. Regen. Res. 12, 1870 (2017), (11) L. Dong, et al., Gene 675, 94 (2018), (12) R. Qiu, et al., Biofactors 45, 975 (2019), (13) C. Huang, et al., Med. Sci. Monit. 25, 5589 (2019)
InChi	InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)19)15-8-12(18)11-4-3-10(17)7-16(11)21-15/h2-8,17,19H,1H3
Quantity	10 mg, Bulk