Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20 mg/ml), DMF (20 mg/ml), methanol (1 mg/ml)
Category: Phytochemicals
Calycosin is an isoflavone and phytoestrogen with diverse biological properties, including anti-cancer, anti-inflammatory, antioxidant, neuroprotective, antiplasmodial and antiprotozoal activities. It is an estrogen receptor (ER) partial agonist that inhibits 17β-estradiol binding to ERα and ER, promotion angiogenesis. It has been shown to have calcium blocking activities. Suppressed breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. Shown to induce apoptosis in several cancer types and having antimetastatic and anti-tumor activities.
Synonyms | 3',7-Dihydroxy-4'-methoxy-isoflavone, 3'-Hydroxyformononetin |
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Purity | ≥98% (HPLC) |
Appearance | White to light yellow powder |
CAS-Number | 20575-57-9 |
Molecular Formula | C16H12O5 |
Molecular Weight | 284.26 |
Identity | 1H-NMR |
Solvents | DMSO (20 mg/ml), DMF (20 mg/ml), methanol (1 mg/ml) |
Smiles | O=C1C=C(C2=CC=C(OC)C(O)=C2)OC3=CC(O)=CC=C31 |
InChi Key | QAGGICSUEVNSGH-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H301 |
Precautionary statements | P301 + P310 |
GHS Symbol | GHS06 |
Signal word | Danger |
RIDADR | UN3462 |
Transportation | Packing Group III |
References | (1) C. Kraft, et al., J. Ethnopharmacol. 73, 131 (2000), (2) D.-H. Yu, et al., Biomed. Environ. Sci. 18, 297 (2005), (3) X.L. Wu, et al., Acta Pharmacol. Sin. 27, 1007 (2006), (4) M.M. Salem & K.A. Werbovetz, J. Nat. Prod. 69, 43 (2006), (5) J.Y. Tang, et al., PLoS One 5, e11822 (2010), (6) C. Guo, et al., J. Ethnopharmacol. 144, 768 (2012), (7) J. Chen, et al., PLoS One 9, e91245 (2014), (8) R. Qiu, et al., Exp. Mol. Pathol. 97, 17 (2014), (9) X. Zhao, et al., Gene 591, 123 (2016), (10) L. Song, et al., Neural. Regen. Res. 12, 1870 (2017), (11) L. Dong, et al., Gene 675, 94 (2018), (12) R. Qiu, et al., Biofactors 45, 975 (2019), (13) C. Huang, et al., Med. Sci. Monit. 25, 5589 (2019) |
InChi | InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)19)15-8-12(18)11-4-3-10(17)7-16(11)21-15/h2-8,17,19H,1H3 |
Quantity | 10 mg, Bulk |