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    Colcemid

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    Colcemid

    SKU
    C0022

    Category: Other Pollutants

    Synonyms
    Demecolcine , N-Deacetyl-N-methylcolchicine
    477-30-5
    CAS-Number
    C21H25NO5
    Molecular Formula
    371.43
    Molecular Weight

    • Product Data
    • Handling
    • Safety Information
    • Details

    Specifications

    Purity
    ≥98% (HPLC)
    Identity
    1H-NMR
    Appearance
    Light yellow powder

    Properties

    Melting Point
    73-75°C
    Solvents
    chloroform (10 mg/ml), ethanol

    Downloads

    Safety Data Sheet
    CDX C0022 MSDS.pdf
    Handling Advice
    Protect from light and moisture.
    Use / Stability
    Stable for at least 2 years after receipt when stored at -20°C.
    Long Term Storage
    -20°C
    Short Term Storage
    +4°C
    Shipping
    AMBIENT
    Transportation
    Excepted Quantities
    RIDADR
    UN2811 6.1
    Signal word
    Danger
    GHS Symbol
    GHS06
    Precautionary statements
    P264, P301 + P310
    Hazard statements
    H300
    Description
    Depolymerizes microtubules and blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
    InChi
    InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3
    References
    (1) K. Ray et al.: Eur. J. Biochem. 142, 577 (1984)
    InChi Key
    NNJPGOLRFBJNIW-UHFFFAOYSA-N
    Smiles
    CNC1CCC2=CC(OC)=C(OC)C(OC)=C2C2=CC=C(OC)C(=O)C=C12

    Depolymerizes microtubules and blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

    SKU: C0022 Category: Other Pollutants
    • Additional information

    Additional information

    Synonyms

    Demecolcine, N-Deacetyl-N-methylcolchicine

    Purity

    ≥98% (HPLC)

    Appearance

    Light yellow powder

    CAS-Number

    477-30-5

    Molecular Formula

    C21H25NO5

    Molecular Weight

    371.43

    Identity

    1H-NMR

    Solvents

    chloroform (10 mg/ml), ethanol

    Melting Point

    73-75°C

    Smiles

    CNC1CCC2=CC(OC)=C(OC)C(OC)=C2C2=CC=C(OC)C(=O)C=C12

    InChi Key

    NNJPGOLRFBJNIW-UHFFFAOYSA-N

    Shipping

    AMBIENT

    Short Term Storage

    +4°C

    Long Term Storage

    -20°C

    Handling Advice

    Protect from light and moisture.

    Use / Stability

    Stable for at least 2 years after receipt when stored at -20°C.

    Hazard statements

    H300

    Precautionary statements

    P264, P301 + P310

    GHS Symbol

    GHS06

    Signal word

    Danger

    RIDADR

    UN2811 6.1

    Transportation

    Excepted Quantities

    References

    (1) K. Ray et al.: Eur. J. Biochem. 142, 577 (1984)

    InChi

    InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3

    Quantity

    25 mg, Bulk

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