Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- chloroform (10 mg/ml), ethanol
- Melting Point
- 73-75°C
Downloads
- Safety Data Sheet
- CDX C0022 MSDS_1.3.pdf
Category: Other Pollutants
Depolymerizes microtubules and blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
Synonyms | Demecolcine, N-Deacetyl-N-methylcolchicine |
---|---|
Purity | ≥98% (HPLC) |
Appearance | Light yellow powder |
CAS-Number | 477-30-5 |
Molecular Formula | C21H25NO5 |
Molecular Weight | 371.43 |
Identity | 1H-NMR |
Solvents | chloroform (10 mg/ml), ethanol |
Melting Point | 73-75°C |
Smiles | CNC1CCC2=CC(OC)=C(OC)C(OC)=C2C2=CC=C(OC)C(=O)C=C12 |
InChi Key | NNJPGOLRFBJNIW-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H300 |
Precautionary statements | P264, P301 + P310 |
GHS Symbol | GHS06 |
Signal word | Danger |
RIDADR | UN2811 6.1 |
Transportation | Excepted Quantities |
References | (1) K. Ray et al.: Eur. J. Biochem. 142, 577 (1984) |
InChi | InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3 |
Quantity | 25 mg, Bulk |