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    Colcemid

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      Colcemid

      SKU
      C0022

      Category: Other Pollutants

      Synonyms
      Demecolcine , N-Deacetyl-N-methylcolchicine
      477-30-5
      CAS-Number
      C21H25NO5
      Molecular Formula
      371.43
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      Light yellow powder

      Properties

      Melting Point
      73-75°C
      Solvents
      chloroform (10 mg/ml), ethanol

      Downloads

      Safety Data Sheet
      CDX C0022 MSDS.pdf
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Long Term Storage
      -20°C
      Short Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Excepted Quantities
      RIDADR
      UN2811 6.1
      Signal word
      Danger
      GHS Symbol
      GHS06
      Precautionary statements
      P264, P301 + P310
      Hazard statements
      H300
      Description
      Depolymerizes microtubules and blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
      InChi
      InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3
      References
      (1) K. Ray et al.: Eur. J. Biochem. 142, 577 (1984)
      InChi Key
      NNJPGOLRFBJNIW-UHFFFAOYSA-N
      Smiles
      CNC1CCC2=CC(OC)=C(OC)C(OC)=C2C2=CC=C(OC)C(=O)C=C12

      Depolymerizes microtubules and blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

      SKU: C0022 Category: Other Pollutants
      • Additional information

      Additional information

      Synonyms

      Demecolcine, N-Deacetyl-N-methylcolchicine

      Purity

      ≥98% (HPLC)

      Appearance

      Light yellow powder

      CAS-Number

      477-30-5

      Molecular Formula

      C21H25NO5

      Molecular Weight

      371.43

      Identity

      1H-NMR

      Solvents

      chloroform (10 mg/ml), ethanol

      Melting Point

      73-75°C

      Smiles

      CNC1CCC2=CC(OC)=C(OC)C(OC)=C2C2=CC=C(OC)C(=O)C=C12

      InChi Key

      NNJPGOLRFBJNIW-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Hazard statements

      H300

      Precautionary statements

      P264, P301 + P310

      GHS Symbol

      GHS06

      Signal word

      Danger

      RIDADR

      UN2811 6.1

      Transportation

      Excepted Quantities

      References

      (1) K. Ray et al.: Eur. J. Biochem. 142, 577 (1984)

      InChi

      InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3

      Quantity

      25 mg, Bulk

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