Available from stock

Deltamethrin

SKU: D0619

Category: Insecticides

52918-63-5
CAS-Number: C₂₂H₁₉Br₂NO₃
Molecular Formula: 505.20
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥97% (HPLC)
Appearance: White to light yellow powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DMSO (15 mg/ml) or ethanol (1 mg/ml). Insoluble in water.
Density: 1.60 g/cm3

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Hazard statements: H301 + H331 - H410
Precautionary statements: P261 - P264 - P270 - P273 - P301 + P310 - P304 + P340 + P311
GHS Symbol: GHS06+GHS09
Signal word: Danger
RIDADR: UN2811
Transportation: Packing Group III

Description: Deltamethrin belongs to the class of synthetic pyrethroids, which are being widely used as insecticides. Deltamethrin acts on voltage-gated sodium channels (VGSCs) and voltage-gated calcium channels (VGCCs) that are the primary targets of these chemicals for toxicity to insects. Deltamethrin can increase neurotransmitter release which is associated with elevated levels of intrasynaptosomal free Ca2+ and protein phosphorylation activities. It acts as a potent inhibitor of calcineurin (protein phosphatase 2B), which results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell. It also modulates sodium channels in the nerve cell membrane. It keeps the Na+ channels in an open state for a long time resulting to hyperactivity of the nervous system in mammals and insects. This compound can be used as a reference compound for analytical studies.
Smiles: O=C(O[C@H](C#N)C1=CC=CC(OC2=CC=CC=C2)=C1)[C@H]3C(C)(C)[C@H]3/C=C(Br)/Br
InChi Key: OWZREIFADZCYQD-DXCJPMOASA-N
References: (1) K. Chinn & T. Narahashi, J. Physiol. 380, 191 (1986) , (2) E. Enan & F. Matsumura, Biochem. Pharmacol. 43, 1777 (1992) , (3) T. Narahashi, Trends Pharmacol. Sci. 13, 236 (1992) , (4) E. Enan & F. Matsumura, Biochem. Pharmacol. 45, 703 (1993) , (5) S.B. Symington & J.M. Clark, Pest. Biochem. Physiol. 82, 1 (2005) , (6) J.M. Clark & S.B. Symington, Invert. Neurosci. 7, 3 (2007) , (7) R. Zeng, et al., Pestic. Biochem. Physiol. 138, 84 (2017) , (8) S.N. Bothe & A. Lampert, Toxicol. Appl. Pharmacol. 428, 115676 (2021)

Deltamethrin belongs to the class of synthetic pyrethroids, which are being widely used as insecticides. Deltamethrin acts on voltage-gated sodium channels (VGSCs) and voltage-gated calcium channels (VGCCs) that are the primary targets of these chemicals for toxicity to insects. Deltamethrin can increase neurotransmitter release which is associated with elevated levels of intrasynaptosomal free Ca2+ and protein phosphorylation activities. It acts as a potent inhibitor of calcineurin (protein phosphatase 2B), which results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell. It also modulates sodium channels in the nerve cell membrane. It keeps the Na+ channels in an open state for a long time resulting to hyperactivity of the nervous system in mammals and insects. This compound can be used as a reference compound for analytical studies.

SKU: D0619 Category: Insecticides

Additional information

Additional information

Purity	≥97% (HPLC)
Appearance	White to light yellow powder
CAS-Number	52918-63-5
Molecular Formula	C22H19Br2NO3
Molecular Weight	505.20
Identity	1H-NMR
Solvents	Soluble in DMSO (15 mg/ml) or ethanol (1 mg/ml). Insoluble in water.
Density	1.60 g/cm3
Smiles	O=C(O[C@H](C#N)C1=CC=CC(OC2=CC=CC=C2)=C1)[C@H]3C(C)(C)[C@H]3/C=C(Br)/Br
InChi Key	OWZREIFADZCYQD-DXCJPMOASA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Hazard statements	H301 + H331 – H410
Precautionary statements	P261 – P264 – P270 – P273 – P301 + P310 – P304 + P340 + P311
GHS Symbol	GHS06+GHS09
Signal word	Danger
RIDADR	UN2811
Transportation	Packing Group III
References	(1) K. Chinn & T. Narahashi, J. Physiol. 380, 191 (1986), (2) E. Enan & F. Matsumura, Biochem. Pharmacol. 43, 1777 (1992), (3) T. Narahashi, Trends Pharmacol. Sci. 13, 236 (1992), (4) E. Enan & F. Matsumura, Biochem. Pharmacol. 45, 703 (1993), (5) S.B. Symington & J.M. Clark, Pest. Biochem. Physiol. 82, 1 (2005), (6) J.M. Clark & S.B. Symington, Invert. Neurosci. 7, 3 (2007), (7) R. Zeng, et al., Pestic. Biochem. Physiol. 138, 84 (2017), (8) S.N. Bothe & A. Lampert, Toxicol. Appl. Pharmacol. 428, 115676 (2021)
Quantity	250 mg, Bulk