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    Enalaprilat

    Available from stock

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      Enalaprilat

      SKU
      E0090

      Category: API's & Intermediates

      Synonyms
      EAL , Enalapril acid , MK-422
      76420-72-9
      CAS-Number
      C18H24N2O5
      Molecular Formula
      348.4
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥99% (HPLC)
      Identity
      1H-NMR
      Appearance
      White crystalline powder

      Properties

      Solvents
      water (slightly)

      Downloads

      Safety Data Sheet
      CDX E0090 MSDS.pdf
      Short Term Storage
      +4°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      -20°C
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Active metabolite enalapril. Nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Shown to improve cardiac preservation via bradykinin receptor and PKC without affecting ATP metabolism. Has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway. Increases PPARbeta/delta expression, without influence on PPARalpha and PPARgamma.
      InChi
      InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1
      References
      (1) D.J. DiPette, et al.: Clin. Pharmacol. Ther. 38, 199 (1985) , (2) J.G. Kelly & K. O'Malley: Clin. Pharmacokinet. 19, 177 (1990) , (3) X. Yang, et al.: J. Mol. Cell Cardiol. 28, 1445 (1996) , (4) R. Lupi, et al.: Eur. J. Endocrinol. 154, 355 (2006) , (5) M. Yu, et al.: Molecules 17, 2738 (2012) , (6) H. Cernecka, et al.: Eur. J. Pharmacol. 714, 472 (2013)
      InChi Key
      LZFZMUMEGBBDTC-QEJZJMRPSA-N
      Smiles
      C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O

      Active metabolite enalapril. Nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Shown to improve cardiac preservation via bradykinin receptor and PKC without affecting ATP metabolism. Has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway. Increases PPARbeta/delta expression, without influence on PPARalpha and PPARgamma.

      SKU: E0090 Category: API's & Intermediates
      • Additional information

      Additional information

      Synonyms

      EAL, Enalapril acid, MK-422

      Purity

      ≥99% (HPLC)

      Appearance

      White crystalline powder

      CAS-Number

      76420-72-9

      Molecular Formula

      C18H24N2O5

      Molecular Weight

      348.4

      Identity

      1H-NMR

      Solvents

      water (slightly)

      Smiles

      C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O

      InChi Key

      LZFZMUMEGBBDTC-QEJZJMRPSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) D.J. DiPette, et al.: Clin. Pharmacol. Ther. 38, 199 (1985), (2) J.G. Kelly & K. O'Malley: Clin. Pharmacokinet. 19, 177 (1990), (3) X. Yang, et al.: J. Mol. Cell Cardiol. 28, 1445 (1996), (4) R. Lupi, et al.: Eur. J. Endocrinol. 154, 355 (2006), (5) M. Yu, et al.: Molecules 17, 2738 (2012), (6) H. Cernecka, et al.: Eur. J. Pharmacol. 714, 472 (2013)

      InChi

      InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1

      Quantity

      50 mg, 250 mg, Bulk

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