Specifications
- Purity
- ≥99% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White crystalline powder
Properties
- Solvents
- water (slightly)
Downloads
- Safety Data Sheet
- CDX E0090 MSDS.pdf
Available from stock
Enalaprilat
- SKU
- E0090
Category: API's & Intermediates
- Synonyms
- EAL , Enalapril acid , MK-422
- 76420-72-9
- CAS-Number
- C18H24N2O5
- Molecular Formula
- 348.4
- Molecular Weight
- Short Term Storage
- +4°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- -20°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- Active metabolite enalapril. Nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Shown to improve cardiac preservation via bradykinin receptor and PKC without affecting ATP metabolism. Has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway. Increases PPARbeta/delta expression, without influence on PPARalpha and PPARgamma.
- InChi
- InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1
- References
- (1) D.J. DiPette, et al.: Clin. Pharmacol. Ther. 38, 199 (1985) , (2) J.G. Kelly & K. O'Malley: Clin. Pharmacokinet. 19, 177 (1990) , (3) X. Yang, et al.: J. Mol. Cell Cardiol. 28, 1445 (1996) , (4) R. Lupi, et al.: Eur. J. Endocrinol. 154, 355 (2006) , (5) M. Yu, et al.: Molecules 17, 2738 (2012) , (6) H. Cernecka, et al.: Eur. J. Pharmacol. 714, 472 (2013)
- InChi Key
- LZFZMUMEGBBDTC-QEJZJMRPSA-N
- Smiles
- C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O
Active metabolite enalapril. Nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Shown to improve cardiac preservation via bradykinin receptor and PKC without affecting ATP metabolism. Has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway. Increases PPARbeta/delta expression, without influence on PPARalpha and PPARgamma.
Additional information
| Synonyms | EAL, Enalapril acid, MK-422 |
|---|---|
| Purity | ≥99% (HPLC) |
| Appearance | White crystalline powder |
| CAS-Number | 76420-72-9 |
| Molecular Formula | C18H24N2O5 |
| Molecular Weight | 348.4 |
| Identity | 1H-NMR |
| Solvents | water (slightly) |
| Smiles | C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O |
| InChi Key | LZFZMUMEGBBDTC-QEJZJMRPSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) D.J. DiPette, et al.: Clin. Pharmacol. Ther. 38, 199 (1985), (2) J.G. Kelly & K. O'Malley: Clin. Pharmacokinet. 19, 177 (1990), (3) X. Yang, et al.: J. Mol. Cell Cardiol. 28, 1445 (1996), (4) R. Lupi, et al.: Eur. J. Endocrinol. 154, 355 (2006), (5) M. Yu, et al.: Molecules 17, 2738 (2012), (6) H. Cernecka, et al.: Eur. J. Pharmacol. 714, 472 (2013) |
| InChi | InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1 |
| Quantity | 50 mg, 250 mg, Bulk |
